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Information on EC 1.21.3.7 - tetrahydrocannabinolic acid synthase

for references in articles please use BRENDA:EC1.21.3.7
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IUBMB Comments
A flavoprotein (FAD). The cofactor is covalently bound. Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta9-THCA with lower efficiency. Whereas the product was originally called Delta1-tetrahydrocannabinolate, the recommended name according to systematic peripheral numbering is Delta9-tetrahydrocannabinolate.
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The expected taxonomic range for this enzyme is: Cannabis sativa
Synonyms
thca synthase, thcas, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cannabigerolate + O2 = DELTA9-tetrahydrocannabinolate + H2O2
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