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Information on EC 1.21.3.1 - isopenicillin-N synthase and Organism(s) Lysobacter lactamgenus and UniProt Accession Q48739

for references in articles please use BRENDA:EC1.21.3.1
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IUBMB Comments
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
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This record set is specific for:
Lysobacter lactamgenus
UNIPROT: Q48739
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Word Map
The taxonomic range for the selected organisms is: Lysobacter lactamgenus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
isopenicillin n synthase, isopenicillin n synthetase, isopenicillin n-synthase, isopenicillin-n synthase, ipn synthase, isopenicillin-n-synthase, isopenicillin n synthase (cyclase), more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isopenicillin-N-synthase
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isopenicillin N synthase
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isopenicillin N synthetase
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synthetase, isopenicillin N (9Cl)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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-
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reduction
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SYSTEMATIC NAME
IUBMB Comments
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)
Forms part of the penicillin biosynthesis pathway (for pathway, click here).
CAS REGISTRY NUMBER
COMMENTARY hide
78642-31-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
isopenicillin N + H2O
show the reaction diagram
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-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2
isopenicillin N + H2O
show the reaction diagram
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
IPNS_LYSLA
326
0
36564
Swiss-Prot
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Francis, W.R.; Shaner, N.C.; Christianson, L.M.; Powers, M.L.; Haddock, S.H.
Occurrence of isopenicillin-N-synthase homologs in bioluminescent ctenophores and implications for coelenterazine biosynthesis
PLoS ONE
10
e0128742
2015
Acremonium chrysogenum (P05189), Amycolatopsis lactamdurans (P27744), Aspergillus nidulans (P05326), Aspergillus nidulans ATCC 38163 (P05326), Crassostrea gigas (K1QF46), Flavobacterium sp. SC 12154 (P16020), Gordonia rubripertincta, Gordonia rubripertincta NBRC 101908, Lysobacter lactamgenus (Q48739), Mycolicibacterium phlei, Mycolicibacterium phlei RIVM601174, Penicillium chrysogenum (P08703), Streptomyces cattleya (Q53932), Streptomyces clavuligerus (P10621), Streptomyces clavuligerus ATCC 27064 (P10621), Streptomyces griseus (Q54243), Streptomyces jumonjinensis (P18286), Streptomyces microflavus (P12438)
Manually annotated by BRENDA team