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Information on EC 1.20.4.4 - arsenate reductase (thioredoxin)

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IUBMB Comments
The enzyme, characterized in bacteria of the Firmicutes phylum, is specific for thioredoxin . It has no activity with glutaredoxin [cf. EC 1.20.4.1, arsenate reductase (glutaredoxin)]. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. The enzyme also has the activity of EC 3.1.3.48, protein-tyrosine-phosphatase .
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
arsc3, sa_arsc, pi258 arsenate reductase, thioredoxin-coupled arsenate reductase, bs_arsc, arsc1', thioredoxin-arsenate reductase complex, trx-coupled arsenate reductase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O
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