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EC Tree
IUBMB Comments The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid.
The enzyme appears in viruses and cellular organisms
Synonyms
GSTO1, GSTO2, MMA(V) reductase, monomethylarsonic acid (MMA V) reductase/hGSTO1, More, reductase, methylarsonate,
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monomethylarsonic acid (MMA V) reductase/hGSTO1
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reductase, methylarsonate
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additional information
identical to omega class glutathione-S-transferase (hGSTO1-1)
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methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O
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gluthathione:methylarsonate oxidoreductase
The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid.
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arsenate + glutathione
arsenite + reduced glutathione
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dimethylarsonate + glutathione
dimethylarsonous acid
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
methylarsonate + glutathione
methylarsonite + oxidized glutathione
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rate-limiting enzyme in biotransformation of inorganic arsenite in rabbit liver
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monomethylarsonate + glutathione
monomethylarsonous acid + oxidized glutathione
methylarsonate + glutathione
methylarsonite + glutathione disulfide
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
involved in biotransformation of arsenate
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
rate limiting enzyme of inorganic arsenic metabolism
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monomethylarsonate + glutathione
monomethylarsonous acid + oxidized glutathione
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monomethylarsonate + glutathione
monomethylarsonous acid + oxidized glutathione
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monomethylarsonate + glutathione
monomethylarsonous acid + oxidized glutathione
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monomethylarsonate + glutathione
monomethylarsonous acid + oxidized glutathione
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
methylarsonate + glutathione
methylarsonite + oxidized glutathione
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rate-limiting enzyme in biotransformation of inorganic arsenite in rabbit liver
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
involved in biotransformation of arsenate
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methylarsonate + glutathione
methylarsonite + glutathione disulfide
rate limiting enzyme of inorganic arsenic metabolism
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dithiothreitol
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stimulates
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20.9
dimethylarsonate
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2.1
monomethylarsonate
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0.27
GSTO1 mutant A140D, 30ưC, pH 5.5
0.33
wild-type GSTO1, 30ưC, pH 5.5
0.39
GSTO1 mutant E208K, 30ưC, pH 5.5
0.42
wild-type GSTO1, 30ưC, pH 5.5
0.44
GSTO2 mutant N142D, 30ưC, pH 5.5
0.65
GSTO1 mutant DELTAE155, 30ưC, pH 5.5
0.67
GSTO1 mutant DELTAE155/E208K, 30ưC, pH 5.5
additional information
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UniProt
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isoforms GSTO1, GSTO2 and their natural polymorphisms. Enzyme has additionally thioltransferase, dehydroascorbate reductase and dimethylarsonate reductase activities
UniProt
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A140D
isoform GSTO2, natural polymorphism, no significant alteration in monomethylarsonate reductase activity
DELTAE155
isoform GSTO2, natural polymorphism, 90% increase in monomethylarsonate reductase activity
DELTAE155/E208K
isoform GSTO2, natural polymorphism, 100% increase in monomethylarsonate reductase activity, decrease in heat stability
E208K
isoform GSTO2, natural polymorphism, slight increase in monomethylarsonate reductase activity, decrease in heat stability
N142D
isoform GSTO2, natural polymorphism, no significant alteration in monomethylarsonate reductase activity
additional information
naturally occurring mutations S86C, A140D, E155del, A236V, and E208K significantly decrease enzyme activity
additional information
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naturally occurring mutations S86C, A140D, E155del, A236V, and E208K significantly decrease enzyme activity
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60
wild-type, 30 min, 60% residual activity. GSTO1 mutant E208K, 30 min, 80% residual activity, GSTO1 mutant DELTAE155/E208K, 30 min, no residual activity
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partial
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Zakharyan, R.A.; Aposhian, H.V.
Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase
Chem. Res. Toxicol.
12
1278-1283
1999
Oryctolagus cuniculus, Homo sapiens
brenda
Sampayo-Reyes, A.; Zakharyan, R.A.; Healy, S.M.; Aposhian, H.V.
Monomethylarsonic acid reductase and monomethylarsonous acid in hamster tissue
Chem. Res. Toxicol.
13
1181-1186
2000
Mesocricetus auratus
brenda
Zakharyan, R.A.; Sampayo-Reyes, A.; Healy, S.M.; Tsaprailis, G.; Board, P.G.; Liebler, D.C.; Aposhian, H.V.
Human monomethylarsonic acid (MMA(V)) reductase is a member of the glutathione-S-transferase superfamily
Chem. Res. Toxicol.
14
1051-1057
2001
Homo sapiens (P78417), Homo sapiens
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Marnell, L.L.; Garcia-Vargas, G.G.; Chowdhury, U.K.; Zakharyan, R.A.; Walsh, B.; Avram, M.D.; Kopplin, M.J.; Cebrian, M.E.; Silbergeld, E.K.; Aposhian, H.V.
Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles
Chem. Res. Toxicol.
16
1507-1513
2003
Homo sapiens (P78417), Homo sapiens
brenda
Schmuck, E.M.; Board, P.G.; Whitbread, A.K.; Tetlow, N.; Cavanaugh, J.A.; Blackburn, A.C.; Masoumi, A.
Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimers and Parkinsons diseases
Pharmacogenet. Genomics
15
493-501
2005
Homo sapiens (P78417), Homo sapiens
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