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Information on EC 1.20.4.1 - arsenate reductase (glutaredoxin)

for references in articles please use BRENDA:EC1.20.4.1
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IUBMB Comments
A molybdoenzyme. The enzyme is part of a system for detoxifying arsenate. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. cf. EC 1.20.4.4, arsenate reductase (thioredoxin).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
Acr2, Acr2p, ACR3-ArsC, All0195, AR, ARSA, ArsC, arsenate reductase, AsV reductase, EC 1.97.1.5, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O
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