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Information on EC 1.20.4.1 - arsenate reductase (glutaredoxin)

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IUBMB Comments
A molybdoenzyme. The enzyme is part of a system for detoxifying arsenate. Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 3.6.3.16, arsenite-transporting ATPase; in other organisms, arsenite can be methylated by EC 2.1.1.137, arsenite methyltransferase, in a pathway that produces non-toxic organoarsenical compounds. cf. EC 1.20.4.4, arsenate reductase (thioredoxin).
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
arsenate reductase, acr2p, asv reductase, pvgrx5, slr0946, synarsc, all0195, mxan_0575, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O
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