Reference on EC 1.2.4.1 - pyruvate dehydrogenase (acetyl-transferring)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ho, L.; Patel, M.S.
Cloning and cDNA sequence of the beta-subunit component of human pyruvate dehydrogenase complex
Gene
86
297-302
1990
Homo sapiens
Hawkins, C.F.; Borges, A.; Perham, R.N.
Cloning and sequence analysis of the genes encoding the alpha and beta subunits of the E1 component of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus
Eur. J. Biochem.
191
337-346
1990
Geobacillus stearothermophilus
Steensma, H.Y.; Holtoman, L.; Dekker, I.; van Sluis, C.A.; Wenzel, T.J
Molecular cloning of the gene for the E1 alpha subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae
Eur. J. Biochem.
191
769-774
1990
Saccharomyces cerevisiae
Ho, L.; Wexler, I.D.; Liu, T.C.; Thekkumara, T.J.; Patel, M.S.
Characterization of cDNAs encoding human pyruvate dehydrogenase alpha subunit
Proc. Natl. Acad. Sci. USA
86
5330-5334
1989
Homo sapiens
Dahl, H.H.M.; Hunt, S.M.; Hutchison, W.M.; Brown, G.K.
The human pyruvate dehydrogenase complex. Isolation of cDNA clones for the E1 alpha subunit, sequence analysis, and characterization of the mRNA
J. Biol. Chem.
262
7398-7403
1987
Homo sapiens
Kerbey, A.L.; Randle, P.J.
Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (E1 component of pyruvate dehydrogenase complex)
Biochem. J.
231
523-529
1985
Sus scrofa
Camp, P.J.; Randall, D.D.
Purification and characterization of the pea chloroplast pyruvate dehydrogenase complex
Plant Physiol.
77
571-577
1985
Pisum sativum
Apfel, M.A.; Ikeda, B.H.; Speckhard, D.C.; Frey, P.A.
Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate
J. Biol. Chem.
259
2905-2909
1984
Escherichia coli
Lowe, P.N.; Leeper, F.J.; Perham, R.N.
Stereoisomers of tetrahydrothiamin pyrophosphate, potent inhibitors of the pyruvate dehydrogenase multienzyme complex from Escherichia coli
Biochemistry
22
150-157
1983
Escherichia coli
Harada, T.; Hirabayashi, T.
Pyruvate dehydrogenase complex from Hansenula
Methods Enzymol.
89
420-423
1982
Hansenula sp.
Randall, D.D.
Pyruvate dehydrogenase complex from broccoli and cauliflower
Methods Enzymol.
89
408-414
1982
Brassica oleracea
-
Pettit, F.H.; Reed, L.J.
Pyruvate dehydrogenase complex from bovine kidney and heart
Methods Enzymol.
89
376-386
1982
Bos taurus
Saumweber, H.; Binder, R.; Bisswanger, H.
Pyruvate dehydrogenase component of the pyruvate dehydrogenase complex from Escherichia coli K12. Purification and characterization
Eur. J. Biochem.
114
407-411
1981
Escherichia coli
Komuniecki, R.; Komuniecki, P.R.; Saz, H.J.
Purification and properties of the Ascaris pyruvate dehydrogenase complex
Biochim. Biophys. Acta
571
1-11
1979
Ascaris lumbricoides
Hamada, M.; Hiraoka, T.; Koike, K.; Ogasahara, K.; Kanzaki, T.; Koike, M.
Properties and subunit structure of pig heart pyruvate dehydrogenase
J. Biochem.
79
1273-1285
1976
Sus scrofa
Reed, L.J.; Willms, C.R.
Purification and resolution of the pyruvate dehydrogenase complex (Escherichia coli)
Methods Enzymol.
9
247-265
1966
Escherichia coli
-
Korotchkina, L.G.; Tucker, M.M.; Thekkumkara, T.J.; Madhusudhan, K.T.; Pons, G.; Kim, H.; Patel, M.S.
Overexpression and characterization of human tetrameric pyruvate dehydrogenase and its individual subunits
Protein Expr. Purif.
6
79-90
1995
Bos taurus, Homo sapiens
Nemerya, N.S.; Zemskova, M.A.; Nyukhalkina, I.A.; Khailova, L.S.
Chemical modification of the essential arginine residues of pyruvate dehydrogenase prevents its phosphorylation by kinase
FEBS Lett.
394
96-98
1996
Pigeon
Jeng, J.; Kallarakal, A.T.; Kim, S.F.; Popov, K.M.; Song, B.J.
Pyruvate dehydrogenase E1alpha isoform in rat testis: cDNA cloning, characterization, and biochemical comparison of the recombinant testis and liver enzymes
Comp. Biochem. Physiol. B
120
205-216
1998
Homo sapiens, Rattus norvegicus
Hengeveld, A.F.; Schoustra, S.E.; Westphal, A.H.; De Kok, A.
Pyruvate dehydrogenase from Azotobacter vinelandii: properties of the N-terminally truncated enzyme
Eur. J. Biochem.
265
1098-1107
1999
Azotobacter vinelandii
Ciszak, E.; Korotchkina, L.G.; Hong, Y.S.; Joachimiak, A.; Patel, M.S.
Crystallization and initial x-ray diffraction analysis of human pyruvate dehydrogenase
Acta Crystallogr. Sect. D
57
465-468
2001
Homo sapiens
Nemeria, N.; Yan, Y.; Zhang, Z.; Brown, A.M.; Arjunan, P.; Furey, W.; Guest, J.R.; Jordan, F.
Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates. Evidence for reversible tight-binding inhibition
J. Biol. Chem.
276
45969-45978
2001
Escherichia coli, Homo sapiens
Moreau, R.; Heath, S.H.D.; Doneanu, C.E.; Harris, R.A.; Hagen, T.M.
Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart
Biochem. Biophys. Res. Commun.
325
48-58
2004
Rattus norvegicus
Arjunan, P.; Nemeria, N.; Brunskill, A.; Chandrasekhar, K.; Sax, M.; Yan, Y.; Jordan, F.; Guest, J.R.; Furey, W.
Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution
Biochemistry
41
5213-5221
2002
Escherichia coli (P0AFG8), Escherichia coli
Park, Y.H.; Wei, W.; Zhou, L.; Nemeria, N.; Jordan, F.
Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit
Biochemistry
43
14037-14046
2004
Escherichia coli
Arjunan, P.; Chandrasekhar, K.; Sax, M.; Brunskill, A.; Nemeria, N.; Jordan, F.; Furey, W.
Structural determinants of enzyme binding affinity: the E1 component of pyruvate dehydrogenase from Escherichia coli in complex with the inhibitor thiamin thiazolone diphosphate
Biochemistry
43
2405-2411
2004
Escherichia coli (P0AFG8), Escherichia coli
Fries, M.; Chauhan, H.J.; Domingo, G.J.; Jung, H.I.; Perham, R.N.
Site-directed mutagenesis of a loop at the active site of E1 (alpha2beta2) of the pyruvate dehydrogenase complex. A possible common sequence motif
Eur. J. Biochem.
270
861-870
2003
Geobacillus stearothermophilus
Yui, R.; Iketani, S.; Mikami, T.; Kubo, T.
Antisense inhibition of mitochondrial pyruvate dehydrogenase E1alpha subunit in anther tapetum causes male sterility
Plant J.
34
57-66
2003
Beta vulgaris
LeClere, S.; Rampey, R.A.; Bartel, B.
IAR4, a gene required for auxin conjugate sensitivity in Arabidopsis, encodes a pyruvate dehydrogenase E1alpha homolog
Plant Physiol.
135
989-999
2004
Arabidopsis thaliana
Kaczowka, S.J.; Reuter, C.J.; Talarico, L.A.; Maupin-Furlow, J.A.
Recombinant production of Zymomonas mobilis pyruvate decarboxylase in the haloarchaeon Haloferax volcanii
Archaea
1
327-334
2005
Zymomonas mobilis
Chandrasekhar, K.; Arjunan, P.; Sax, M.; Nemeria, N.; Jordan, F.; Furey, W.
Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 A resolution
Acta crystallogr. Sect. D
62
1382-1386
2006
Escherichia coli (P0AFG8), Escherichia coli
Seifert, F.; Golbik, R.; Brauer, J.; Lilie, H.; Schroeder-Tittmann, K.; Hinze, E.; Korotchkina, L.G.; Patel, M.S.; Tittmann, K.
Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation
Biochemistry
45
12775-12785
2006
Homo sapiens
Schreiner, M.E.; Fiur, D.; Holatko, J.; Patek, M.; Eikmanns, B.J.
E1 enzyme of the pyruvate dehydrogenase complex in Corynebacterium glutamicum: molecular analysis of the gene and phylogenetic aspects
J. Bacteriol.
187
6005-6018
2005
Corynebacterium glutamicum (Q8NNF6)
Soo, P.C.; Horng, Y.T.; Lai, M.J.; Wei, J.R.; Hsieh, S.C.; Chang, Y.L.; Tsai, Y.H.; Lai, H.C.
Pirin regulates pyruvate catabolism by interacting with the pyruvate dehydrogenase E1 subunit and modulating pyruvate dehydrogenase activity
J. Bacteriol.
189
109-118
2007
Serratia marcescens
Arjunan, P.; Sax, M.; Brunskill, A.; Chandrasekhar, K.; Nemeria, N.; Zhang, S.; Jordan, F.; Furey, W.
A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct
J. Biol. Chem.
281
15296-15303
2006
Escherichia coli (P0AFG8), Escherichia coli
Fries, M.; Stott, K.M.; Reynolds, S.; Perham, R.N.
Distinct modes of recognition of the lipoyl domain as substrate by the E1 and E3 components of the pyruvate dehydrogenase multienzyme complex
J. Mol. Biol.
366
132-139
2006
Geobacillus stearothermophilus
Gurd, B.J.; Peters, S.J.; Heigenhauser, G.J.; LeBlanc, P.J.; Doherty, T.J.; Paterson, D.H.; Kowalchuk, J.M.
O2 uptake kinetics, pyruvate dehydrogenase activity, and muscle deoxygenation in young and older adults during the transition to moderate-intensity exercise
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R577-R584
2008
Homo sapiens
Seifert, F.; Ciszak, E.; Korotchkina, L.; Golbik, R.; Spinka, M.; Dominiak, P.; Sidhu, S.; Brauer, J.; Patel, M.S.; Tittmann, K.
Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex
Biochemistry
46
6277-6287
2007
Homo sapiens (P08559), Homo sapiens
Xiong, Y.; Li, Y.; He, H.; Zhan, C.G.
Theoretical calculation of the binding free energies for pyruvate dehydrogenase E1 binding with ligands
Bioorg. Med. Chem. Lett.
17
5186-5190
2007
Escherichia coli
Fleige, T.; Fischer, K.; Ferguson, D.J.; Gross, U.; Bohne, W.
Carbohydrate metabolism in the Toxoplasma gondii apicoplast: localization of three glycolytic isoenzymes, the single pyruvate dehydrogenase complex, and a plastid phosphate translocator
Eukaryot. Cell
6
984-996
2007
Toxoplasma gondii (Q1KSF0)
Korotchkina, L.G.; Patel, M.S.
Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex
FEBS Lett.
582
468-472
2008
Homo sapiens
Peng, H.; Wang, T.; Xie, P.; Chen, T.; He, H.W.; Wan, J.
Molecular docking and three-dimensional quantitative structure-activity relationship studies on the binding modes of herbicidal 1-(substituted phenoxyacetoxy)alkylphosphonates to the E1 component of pyruvate dehydrogenase
J. Agric. Food Chem.
55
1871-1880
2007
Escherichia coli (P0AFG8)
Kale, S.; Arjunan, P.; Furey, W.; Jordan, F.
A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component
J. Biol. Chem.
282
28106-28116
2007
Escherichia coli (P0AFG8), Escherichia coli
Kale, S.; Ulas, G.; Song, J.; Brudvig, G.W.; Furey, W.; Jordan, F.
Efficient coupling of catalysis and dynamics in the E1 component of Escherichia coli pyruvate dehydrogenase multienzyme complex
Proc. Natl. Acad. Sci. USA
105
1158-1163
2008
Escherichia coli
Roberts, D.P.; McKenna, L.F.; Lohrke, S.M.; Rehner, S.; De Souza, J.T.
Pyruvate dehydrogenase activity is important for colonization of seeds and roots by Enterobacter cloacae
Soil Biol. Biochem.
39
2150-2159
2007
Enterobacter cloacae (A2TC23), Enterobacter cloacae 501R3 (A2TC23)
Joao Silva, M.; Pinheiro, A.; Eusebio, F.; Gaspar, A.; Tavares de Almeida, I.; Rivera, I.
Pyruvate dehydrogenase deficiency: identification of a novel mutation in the PDHA1 gene which responds to amino acid supplementation
Eur. J. Pediatr.
168
17-22
2009
Homo sapiens
Li, J.; Kato, M.; Chuang, D.T.
Pivotal role of the C-terminal DW-motif in mediating inhibition of pyruvate dehydrogenase kinase 2 by dichloroacetate
J. Biol. Chem.
284
34458-34467
2009
Homo sapiens
Glushakova, L.G.; Lisankie, M.J.; Eruslanov, E.B.; Ojano-Dirain, C.; Zolotukhin, I.; Liu, C.; Srivastava, A.; Stacpoole, P.W.
AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells
Mol. Genet. Metab.
98
289-299
2009
Homo sapiens
Rardin, M.J.; Wiley, S.E.; Naviaux, R.K.; Murphy, A.N.; Dixon, J.E.
Monitoring phosphorylation of the pyruvate dehydrogenase complex
Anal. Biochem.
389
157-164
2009
Mus musculus, Homo sapiens (P08559)
Kohda, Y.; Umeki, M.; Kono, T.; Terasaki, F.; Matsumura, H.; Tanaka, T.
Thiamine ameliorates diabetes-induced inhibition of pyruvate dehydrogenase (PDH) in rat heart mitochondria: investigating the discrepancy between PDH activity and PDH E1alpha phosphorylation in cardiac fibroblasts exposed to high glucose
J. Pharmacol. Sci.
113
343-352
2010
Rattus norvegicus
Krause, F.S.; Blombach, B.; Eikmanns, B.J.
Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production
Appl. Environ. Microbiol.
76
8053-8061
2010
Corynebacterium glutamicum (Q8NNF6), Corynebacterium glutamicum DSM 20300 (Q8NNF6)
Balakrishnan, A.; Nemeria, N.S.; Chakraborty, S.; Kakalis, L.; Jordan, F.
Determination of pre-steady-state rate constants on the Escherichia coli pyruvate dehydrogenase complex reveals that loop movement controls the rate-limiting step
J. Am. Chem. Soc.
134
18644-18655
2012
Escherichia coli
Chandrasekhar, K.; Wang, J.; Arjunan, P.; Sax, M.; Park, Y.H.; Nemeria, N.S.; Kumaran, S.; Song, J.; Jordan, F.; Furey, W.
Insight to the interaction of the dihydrolipoamide acetyltransferase (E2) core with the peripheral components in the Escherichia coli pyruvate dehydrogenase complex via multifaceted structural approaches
J. Biol. Chem.
288
15402-15417
2013
Escherichia coli
Eram, M.S.; Oduaran, E.; Ma, K..
The bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase from Thermococcus guaymasensis
Archaea
2014
349379
2014
Sus scrofa
Fries, M.; Jung, H.I.; Perham, R.N.
Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes
Biochemistry
42
6996-7002
2003
Geobacillus stearothermophilus
Chauhan, H.J.; Domingo, G.J.; Jung, H.I.; Perham, R.N.
Sites of limited proteolysis in the pyruvate decarboxylase component of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus and their role in catalysis
Eur. J. Biochem.
267
7158-7169
2000
Geobacillus stearothermophilus
Jung, H.I.; Perham, R.N.
Prediction of the binding site on E1 in the assembly of the pyruvate dehydrogenase multienzyme complex of Bacillus stearothermophilus
FEBS Lett.
555
405-410
2003
Geobacillus stearothermophilus (P21874), Geobacillus stearothermophilus
Inoue, H.; Nishito, A.; Eriguchi, S.; Tamura, T.; Inagaki, K.; Tanaka, H.
Purification and substrate characterization of alpha-ketobutyrate decarboxylase from Pseudomonas putida
J. Mol. Catal. B
23
265-271
2003
Pseudomonas putida (O33468)
-
Broz, A.K.; Tovar-Mendez, A.; Mooney, B.P.; Johnston, M.L.; Miernyk, J.A.; Randall, D.D.
A novel regulatory mechanism based upon a dynamic core structure for the mitochondrial pyruvate dehydrogenase complex?
Mitochondrion
19
144-153
2014
Arabidopsis thaliana
Lacroix, M.; Rodier, G.; Kirsh, O.; Houles, T.; Delpech, H.; Seyran, B.; Gayte, L.; Casas, F.; Pessemesse, L.; Heuillet, M.; Bellvert, F.; Portais, J.C.; Berthet, C.; Bernex, F.; Brivet, M.; Boutron, A.; Le Cam, L.; Sardet, C.
E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity
Proc. Natl. Acad. Sci. USA
113
10998-11003
2016
Mus musculus
Goguet-Rubio, P.; Seyran, B.; Gayte, L.; Bernex, F.; Sutter, A.; Delpech, H.; Linares, L.K.; Riscal, R.; Repond, C.; Rodier, G.; Kirsh, O.; Touhami, J.; Noel, J.; Vincent, C.; Pirot, N.; Pavlovic, G.; Herault, Y.; Sitbon, M.; Pellerin, L.; Sardet, C.; Lacroix, M.; Le Cam, L.
E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis
Proc. Natl. Acad. Sci. USA
113
11004-11009
2016
Mus musculus
Jeng, J.; Huh, T.L.; Song, B.J.
Production of an enzymatically active E1 component of human pyruvate dehydrogenase complex in Escherichia coli supporting role of E1 beta subunit in E1 activity
Biochem. Biophys. Res. Commun.
203
225-230
1994
Homo sapiens (P08559 and P11177), Homo sapiens
He, J.B.; He, H.F.; Zhao, L.L.; Zhang, L.; You, G.Y.; Feng, L.L.; Wan, J.; He, H.W.
Synthesis and antifungal activity of 5-iodo-1,4-disubstituted-1,2,3-triazole derivatives as pyruvate dehydrogenase complex E1 inhibitors
Bioorg. Med. Chem.
23
1395-1401
2015
Escherichia coli
Wijenayake, S.; Luu, B.E.; Zhang, J.; Tessier, S.N.; Quintero-Galvis, J.F.; Gaitan-Espitia, J.D.; Nespolo, R.F.; Storey, K.B.
Strategies of biochemical adaptation for hibernation in a South American marsupial, Dromiciops gliroides 4. Regulation of pyruvate dehydrogenase complex and metabolic fuel selection
Comp. Biochem. Physiol. B
224
32-37
2018
Dromiciops gliroides
Hengeveld, A.F.; Westphal, A.H.; de Kok, A.
Expression and characterisation of the homodimeric E1 component of the Azotobacter vinelandii pyruvate dehydrogenase complex
Eur. J. Biochem.
250
260-268
1997
Azotobacter vinelandii (V9H1F5)
Gey, U.; Czupalla, C.; Hoflack, B.; Roedel, G.; Krause-Buchholz, U.
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases
J. Biol. Chem.
283
9759-9767
2008
Saccharomyces cerevisiae (P16387)
Lee, J.; Oh, S.; Bhattacharya, S.; Zhang, Y.; Florens, L.; Washburn, M.P.; Workman, J.L.
The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity
PLoS ONE
15
e0243489
2020
Saccharomyces cerevisiae (P16387), Saccharomyces cerevisiae BY4741 (P16387)
Feng, J.; He, H.; Zhou, Y.; Cai, M.; Peng, H.; Liu, H.; Liu, L.; Feng, L.; He, H.
Structure optimization and bioactivity evaluation of ThDP analogs targeting cyanobacterial pyruvate dehydrogenase E1
Bioorg. Med. Chem.
27
115159
2019
Synechocystis sp. PCC 6803 (P74490 and P73405)
Wei, T.; Huang, G.; Liu, P.; Gao, J.; Huang, C.; Sun, M.; Shen, W.
Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions
Cell Death Dis.
10
614
2019
Mus musculus (P35486)
Kyrilis, F.L.; Semchonok, D.A.; Skalidis, I.; Tueting, C.; Hamdi, F.; OReilly, F.J.; Rappsilber, J.; Kastritis, P.L.
Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts
Cell Rep.
34
108727
2021
Thermochaetoides thermophila (G0SHF3 and G0RYE0), Thermochaetoides thermophila DSM 1495 (G0SHF3 and G0RYE0)
Moeller, J.; Bhat, K.; Guhl, L.; Poertner, R.; Jandt, U.; Zeng, A.P.
Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells
Eng. Life Sci.
21
100-114
2021
Cricetulus griseus (G3H5K6)
Usman, B.; Nawaz, G.; Zhao, N.; Liao, S.; Qin, B.; Liu, F.; Liu, Y.; Li, R.
Programmed editing of rice ( Oryza sativa L.) OsSPL16 gene using CRISPR/Cas9 improves grain yield by modulating the expression of pyruvate enzymes and cell cycle proteins
Int. J. Mol. Sci.
22
249
2020
Oryza sativa Indica Group (A2XPT6 and A2Z2Z0)
Hezaveh, S.; Zeng, A.P.; Jandt, U.
Full enzyme complex simulation interactions in human pyruvate dehydrogenase complex
J. Chem. Inf. Model.
58
362-369
2018
Homo sapiens
Grabowska, E.; Czerniecka, M.; Czyzewska, U.; Zambrzycka, A.; Lotowski, Z.; Tylicki, A.
Differences in the efficiency of 3-deazathiamine and oxythiamine pyrophosphates as inhibitors of pyruvate dehydrogenase complex and growth of HeLa cells in vitro
J. Enzyme Inhib. Med. Chem.
36
122-129
2021
Homo sapiens, Sus scrofa
He, J.; He, H.; Cai, M.; Zhao, F.; He, H.
Insight into the halogen bonding between PA-1 ligand and pyruvate dehydrogenase complex E1 component by crystal structure, DFT calculation, and molecular docking
J. Mol. Struct.
1199
126991
2020
Escherichia coli (P0AFG8)
-
Bao, S.; Ding, X.; Yu, S.; Xing, X.; Ding, C.
Characterization of pyruvate dehydrogenase complex E1 alpha and beta subunits of Mycoplasma synoviae
Microb. Pathog.
155
104851
2021
Mycoplasmopsis synoviae, Mycoplasmopsis synoviae WVU1853
Palmieri, E.M.; Gonzalez-Cotto, M.; Baseler, W.A.; Davies, L.C.; Ghesquiere, B.; Maio, N.; Rice, C.M.; Rouault, T.A.; Cassel, T.; Higashi, R.M.; Lane, A.N.; Fan, T.W.; Wink, D.A.; McVicar, D.W.
Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
Nat. Commun.
11
698
2020
Mus musculus
Ohbayashi, I.; Huang, S.; Fukaki, H.; Song, X.; Sun, S.; Morita, M.T.; Tasaka, M.; Millar, A.H.; Furutani, M.
Mitochondrial pyruvate dehydrogenase contributes to auxin-regulated organ development
Plant Physiol.
180
896-909
2019
Arabidopsis thaliana (Q8H1Y0 and Q38799)
Qi, J.; Zhang, F.; Wang, Y.; Liu, T.; Tan, L.; Wang, S.; Tian, M.; Li, T.; Wang, X.; Ding, C.; Yu, S.
Characterization of Mycoplasma gallisepticum pyruvate dehydrogenase alpha and beta subunits and their roles in cytoadherence
PLoS ONE
13
e0208745
2018
Mycoplasma gallisepticum (Q7NAZ8), Mycoplasma gallisepticum, Mycoplasma gallisepticum CVCC 1651 (Q7NAZ8)
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