Information on EC 1.2.3.9 - aryl-aldehyde oxidase

for references in articles please use BRENDA:EC1.2.3.9
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

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EC NUMBER
COMMENTARY hide
1.2.3.9
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RECOMMENDED NAME
GeneOntology No.
aryl-aldehyde oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aromatic aldehyde + O2 + H2O = an aromatic carboxylate + H2O2
show the reaction diagram
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
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redox reaction
-
-
-
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reduction
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
aryl-aldehyde:oxygen oxidoreductase
Acts on benzaldehyde, vanillin and a number of other aromatic aldehydes, but not on aliphatic aldehydes or sugars.
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CAS REGISTRY NUMBER
COMMENTARY hide
82657-93-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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-
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Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
Streptomyces viridosporus T7A / ATCC 39115
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-
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
anisic acid + ?
anisaldehyde + ?
show the reaction diagram
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-
-
-
?
aromatic aldehyde + O2 + H2O
aromatic acid + H2O2
show the reaction diagram
-
Streptomyces viridosporus catabolizes aromatic acids by the beta-ketoadipate and gentisate pathways
-
-
r
benzaldehyde + O2 + H2O
benzoic acid + H2O2
show the reaction diagram
benzoic acid + ?
benzaldehyde + ?
show the reaction diagram
-
-
-
-
?
benzoic acid + H2O2
benzaldehyde + H2O + O2
show the reaction diagram
dehydrodivanillin + O2 + H2O
dehydrodivanillic acid + H2O2
show the reaction diagram
isophthalaldehyde + O2 + H2O
isophthalic acid + H2O2
show the reaction diagram
-
semialdehyde intermediate demostrated by mass spectrometry
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-
r
m-hydroxybenzaldehyde + O2 + H2O
m-hydroxybenzoic acid + H2O2
show the reaction diagram
p-hydroxybenzaldehyde + O2 + H2O
p-hydroxybenzoic acid + H2O2
show the reaction diagram
p-hydroxybenzoic acid + ?
p-hydroxybenzaldehyde + ?
show the reaction diagram
-
-
-
-
?
phthalaldehyde + O2 + H2O
phthalic acid + H2O2
show the reaction diagram
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-
-
-
r
protocatechualdehyde + O2 + H2O
protocatechuic acid + H2O2
show the reaction diagram
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-
-
-
r
salicylaldehyde + O2 + H2O
salicylic acid + H2O2
show the reaction diagram
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-
-
-
r
syringaldehyde + O2 + H2O
syringic acid + H2O2
show the reaction diagram
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-
-
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r
terephthalaldehyde + O2 + H2O
terephthalic acid + H2O2
show the reaction diagram
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semialdehyde intermediate demostrated by mass spectrometry
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-
r
vanillin + O2 + H2O
vanillic acid + H2O2
show the reaction diagram
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-
-
-
r
veratraldehyde + O2 + H2O
veratric acid + H2O2
show the reaction diagram
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-
-
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r
veratric acid + ?
veratraldehyde + ?
show the reaction diagram
-
-
-
-
?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aromatic aldehyde + O2 + H2O
aromatic acid + H2O2
show the reaction diagram
-
Streptomyces viridosporus catabolizes aromatic acids by the beta-ketoadipate and gentisate pathways
-
-
r
benzoic acid + H2O2
benzaldehyde + H2O + O2
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
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together with NADPH necessary for the reduction of benzoic acid via a benzoyl-AMP intermediate
NADPH
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together with ATP necessary for the reduction of benzoic acid via a benzoyl-AMP intermediate
additional information
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no effect NADP+, NAD+, NADH and NADPH
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cycloheximide
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complete inhibition
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.01
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oxidation of protocatechualdehyde
0.012
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intracellular activity of the reduction of veratric acid
0.04
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oxidation of p-hydroxybenzaldehyde
0.05
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oxidation of dehydrodivanillin
0.07
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oxidation of syringaldehyde
0.08
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oxidation of benzaldehyde
0.09
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oxidation of terephthalaldehyde; oxidation of vanillin; oxidation of veratraldehyde
0.1
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oxidation of isophthalaldehyde
0.11
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oxidation of salycylaldehyde
0.15
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oxidation of m-hydroxybenzaldehyde
6.5
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reduction of benzoic acid
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
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assay at
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
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assay at
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial purification
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LINKS TO OTHER DATABASES (specific for EC-Number 1.2.3.9)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)