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Information on EC 1.2.3.3 - pyruvate oxidase

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EC Tree
     1 Oxidoreductases
         1.2 Acting on the aldehyde or oxo group of donors
             1.2.3 With oxygen as acceptor
                1.2.3.3 pyruvate oxidase
IUBMB Comments
A flavoprotein (FAD) requiring thiamine diphosphate. Two reducing equivalents are transferred from the resonant carbanion/enamine forms of 2-hydroxyethyl-thiamine-diphosphate to the adjacent flavin cofactor, yielding 2-acetyl-thiamine diphosphate (AcThDP) and reduced flavin. FADH2 is reoxidized by O2 to yield H2O2 and FAD and AcThDP is cleaved phosphorolytically to acetyl phosphate and thiamine diphosphate .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
pyruvate oxidase, pyrox, pox-2, acetyl phosphate-producing pyruvate oxidase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
pyruvate + phosphate + O2 = acetyl phosphate + CO2 + H2O2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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