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EC Tree
IUBMB Comments Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].
The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
The taxonomic range for the selected organisms is: Zea mays The enzyme appears in selected viruses and cellular organisms
Synonyms
aldehyde oxidase, aldehyde oxidase 1, retinal oxidase, formate oxidase, maox3, atraaox2, aldehyde oxidase 3, aldehyde oxidase 2, aldehyde:oxygen oxidoreductase,
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quinoline oxidase
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aldehyde:oxygen oxidoreductase
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].
The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
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acetaldehyde + H2O + O2
acetate + H2O2
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-
-
-
r
benzaldehyde + H2O + O2
benzoic acid + H2O2
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2,6-dichlorophenol-indophenol also as electron acceptor
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-
?
butyraldehyde + H2O + O2
butanoate + H2O2
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-
-
-
r
indole 3-acetaldehyde + H2O + O2
indole 3-acetic acid + H2O2
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2,6-dichlorophenol-indophenol also as electron acceptor
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-
?
indole 3-carbaldehyde + H2O + O2
indole 3-carboxylate + H2O2
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2,6-dichlorophenol-indophenol also as electron acceptor
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-
?
phenylacetaldehyde + H2O + O2
phenylacetic acid + H2O2
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2,6-dichlorophenol-indophenol as electron acceptor
-
-
?
propionaldehyde + H2O + O2
propionate + H2O2
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-
-
-
r
protocatechualdehyde + H2O + O2
protocatechuic acid + H2O2
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2,6-dichlorophenol-indophenol also as electron acceptor
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-
?
additional information
?
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3(4,5-dimethylthiazolyl-2)2,5-diphenyltetrazolium-bromide, ferricyanide and cytochrome c can also act as electron acceptors, the latter two are not so efficient
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?
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2-mercaptoethanol
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40% inhibition at 5 mM
iodoacetate
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31% inhibition at 1 mM
p-chloromercuribenzoic acid
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61% inhibition at 0.05 mM
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0.345
acetaldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.0015 - 0.005
benzaldehyde
0.026
Butyraldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.0032 - 0.005
Indole-3-acetaldehyde
0.0045 - 0.014
Indole-3-aldehyde
0.25
phenylacetaldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.074
propionaldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.0029 - 0.026
Protocatechualdehyde
0.0015
benzaldehyde
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O2 as electron acceptor
0.005
benzaldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.0032
Indole-3-acetaldehyde
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O2 as electron acceptor
0.005
Indole-3-acetaldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.0045
Indole-3-aldehyde
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O2 as electron acceptor
0.014
Indole-3-aldehyde
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2,6-dichlorophenol-indophenol as electron acceptor
0.0029
Protocatechualdehyde
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O2 as electron acceptor
0.026
Protocatechualdehyde
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2,6-dichlorophenol-indophenol as electron acceptor
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UniProt
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ALDO1_MAIZE
1358
0
146683
Swiss-Prot
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150000
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alpha2, 2 * 150000, SDS-PAGE
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dimer
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alpha2, 2 * 150000, SDS-PAGE
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100
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after 5 min complete activity loss
60 - 70
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relatively stable
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Methanol
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27% activity with 2% v/v methanol
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-30°C, 20 mM Tris-HCl buffer, pH 8.0
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Koshiba, T.; Saito, E.; Ono, N.; Yamamoto, N.; Sato, M.
Purification and properties of flavin- and molybdenum-containing aldehyde oxidase from coleoptiles of maize
Plant Physiol.
110
781-789
1996
Zea mays
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Garattini, E.; Fratelli, M.; Terao, M.
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
Cell. Mol. Life Sci.
65
1019-1048
2008
Arabidopsis thaliana (Q7G191), Arabidopsis thaliana (Q7G192), Arabidopsis thaliana (Q7G193), Bos taurus (P48034), Caenorhabditis elegans (O61198), Caenorhabditis elegans (Q960A1), Canis lupus familiaris (Q2QB47), Canis lupus familiaris (Q2QB48), Danio rerio, Drosophila melanogaster, Drosophila melanogaster (Q9VF53), Equus caballus, Gallus gallus (Q2QB49), Gallus gallus (Q2QB50), Homo sapiens, Macaca fascicularis (Q5FB27), Macaca mulatta, Mamestra brassicae (Q4VGM3), Monodelphis domestica, Mus musculus, Mus musculus (O54754), Mus musculus (Q5SGK3), Mus musculus (Q6V956), Mus musculus (Q8VJ15), no activity in Aspergillus nidulans, Oryctolagus cuniculus (P80456), Pan troglodytes, Pongo pygmaeus, Rattus norvegicus, Rattus norvegicus (Q5QE78), Rattus norvegicus (Q5QE79), Rattus norvegicus (Q5QE80), Rattus norvegicus (Q9Z0U5), Solanum lycopersicum (Q9FV23), Solanum lycopersicum (Q9FV24), Solanum lycopersicum (Q9FV25), Takifugu rubripes, Tetraodon nigroviridis, Xenopus laevis (Q6GMC5), Zea mays (O23887), Zea mays (O23888)
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