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EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
dehydrogenase, formate (cytochrome), FDH, FdnG, FdoG, formate dehydrogenase, formate dehydrogenase-N, formate dehydrogenase-O, formate:cytochrome b1 oxidoreductase, formate:phenazine methosulfate oxidoreductase, respiratory formate dehydrogenase,
more
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dehydrogenase, formate (cytochrome)
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formate dehydrogenase
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formate dehydrogenase-N
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isozyme
formate dehydrogenase-O
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isozyme
formate:cytochrome b1 oxidoreductase
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formate:phenazine methosulfate oxidoreductase
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respiratory formate dehydrogenase
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respiratory formate dehydrogenases are redox enzymes that comprise three subunits: a molybdenum cofactor- and FeS cluster-containing catalytic subunit, an electron-transferring ferredoxin, and a membrane-integral cytochrome b
FDH
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formate + 2 ferricytochrome b1 = CO2 + 2 ferrocytochrome b1 + 2 H+
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formate:ferricytochrome-b1 oxidoreductase
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formate + ferricytochrome b
CO2 + ferrocytochrome b
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additional information
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crude extract of Escherichia coli is investigated for formic dehydrogenase activity. The extract is very active with methylene blue in the presence of formate. Spectroscopic examination shows that the formic dehydrogenase of the extract reacts normally with O2 through cytochrome b
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cytochrome c
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in its purest state the enzyme contains one molecule of cytochrome co-ordinated by two histidine side chains in the oxidized state
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Se
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enzyme from cells grown in selenite contains selenium, covalently bound to the largest subunit
Iron
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enzyme contains an iron-sulfur centre
Iron
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2 mol haeme per mol enzyme, non-haeme iron has not been routinely determined, enzyme contains [3Fe-4S] cluster
Molybdenum
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enzyme contains molybdenum
Molybdenum
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1.4 mol per mol enzyme
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additional information
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FdhE binds to the molybdoprotein subunits (FdnG and FdoG) of the respiratory formate dehydrogenase
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420
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preparation I, 30ưC
752
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preparation II, 30ưC
760
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preparation III, 30ưC
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brenda
N.C.T.C. 6750
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brenda
N.C.T.C. 6750
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brenda
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brenda
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cytoplasmic membrane. Transmembranous locations of the 32000 Da subunit and the 110000 Da subunit
brenda
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A0A1P8QL43_METEX
980
0
107727
TrEMBL
-
A3RRW7_RALSL
998
0
110717
TrEMBL
-
W8VGJ3_KLEPN
205
1
22707
TrEMBL
-
A0A2N8M632_9RHIZ
106
0
11465
TrEMBL
-
A0A2B4N6R2_9BACI
102
0
10975
TrEMBL
-
A0A0A6ZSS0_SHIDY
240
0
27067
TrEMBL
-
A0A2E1QDD4_9EURY
157
0
17097
TrEMBL
-
A0A0E1CDQ7_KLEPN
803
0
89932
TrEMBL
-
A0A0E1CEA7_KLEPN
205
1
22707
TrEMBL
-
A0A0A6ZSF1_SHIDY
75
0
9067
TrEMBL
-
C5AS20_METEA
Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
980
0
107741
TrEMBL
-
Q5E543_ALIF1
Aliivibrio fischeri (strain ATCC 700601 / ES114)
340
6
38485
TrEMBL
-
W8V2L3_KLEPN
211
4
24703
TrEMBL
-
Q2LVY5_SYNAS
Syntrophus aciditrophicus (strain SB)
222
4
24960
TrEMBL
-
Q2LQE3_SYNAS
Syntrophus aciditrophicus (strain SB)
195
1
21567
TrEMBL
-
A3RRX0_RALSL
384
5
42375
TrEMBL
-
A0A0E1CR88_KLEPN
804
0
89363
TrEMBL
-
A0A0E1CI71_KLEPN
226
4
26642
TrEMBL
-
A0A7Z7VVZ2_STASA
322
0
35900
TrEMBL
-
C5AS21_METEA
Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
198
0
21673
TrEMBL
-
Q84FZ7_METEX
198
0
21673
TrEMBL
-
E2X352_SHIDY
211
4
24606
TrEMBL
-
W8UHG9_KLEPN
226
4
26642
TrEMBL
-
A0A2E0HS10_9GAMM
398
0
43643
TrEMBL
-
Q165C2_ROSDO
Roseobacter denitrificans (strain ATCC 33942 / OCh 114)
960
0
106217
TrEMBL
-
C5AS22_METEA
Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
345
6
38096
TrEMBL
-
A0A0U5MIA5_9PROT
962
0
106109
TrEMBL
-
A0A0E1CRS2_KLEPN
195
0
21340
TrEMBL
-
B8CVG2_SHEPW
Shewanella piezotolerans (strain WP3 / JCM 13877)
189
0
20380
TrEMBL
-
A0A0A6ZSK4_SHIDY
282
0
31888
TrEMBL
-
A0A7U4AWB9_STAAU
341
0
38118
TrEMBL
-
A0A068NMT6_9ACTO
396
0
43355
TrEMBL
-
A0A4Y1MSG4_9PROT
813
0
91816
TrEMBL
-
B8CVG3_SHEPW
Shewanella piezotolerans (strain WP3 / JCM 13877)
951
0
106255
TrEMBL
-
C7C9E9_METED
Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)
345
6
38048
TrEMBL
-
Q2LQE4_SYNAS
Syntrophus aciditrophicus (strain SB)
811
0
90765
TrEMBL
-
A0A192C793_ECOLX
803
0
89749
TrEMBL
-
Q2LQE6_SYNAS
Syntrophus aciditrophicus (strain SB)
221
4
24836
TrEMBL
-
Q5E541_ALIF1
Aliivibrio fischeri (strain ATCC 700601 / ES114)
951
0
106782
TrEMBL
-
A3RRW8_RALSL
228
0
23952
TrEMBL
-
B8CVG7_SHEPW
Shewanella piezotolerans (strain WP3 / JCM 13877)
949
1
106177
TrEMBL
-
B8CVG6_SHEPW
Shewanella piezotolerans (strain WP3 / JCM 13877)
195
0
20965
TrEMBL
-
B6AYR9_9RHOB
134
0
14285
TrEMBL
-
A0A7L5MDJ1_MYCPC
384
0
42286
TrEMBL
-
A0A2D7RMF6_9GAMM
261
0
29052
TrEMBL
-
A0A0A6ZSK8_SHIDY
223
4
26139
TrEMBL
-
Q2LVY7_SYNAS
Syntrophus aciditrophicus (strain SB)
830
0
92876
TrEMBL
-
I5D366_9BURK
276
0
29720
TrEMBL
-
A0A4Y1MSU7_9PROT
328
0
35964
TrEMBL
-
A0A192C5Z2_ECOLX
195
0
21465
TrEMBL
-
E2X354_SHIDY
804
0
89528
TrEMBL
-
A0A090NWN9_SHIDY
189
0
21020
TrEMBL
-
A0A7U7EWU2_STAAU
391
1
43694
TrEMBL
-
A0A5E4XSM1_9BURK
134
0
14479
TrEMBL
-
E2XH05_SHIDY
189
0
21020
TrEMBL
-
A0A7V8LJN2_9MYCO
394
0
42700
TrEMBL
-
A0A090NCK0_SHIDY
195
0
21456
TrEMBL
-
A0A3S4H8Q7_9GAMM
70
0
7484
TrEMBL
-
A0A192CE99_ECOLX
195
0
21368
TrEMBL
-
A0A2N9AZ84_METEX
345
6
38048
TrEMBL
-
Q2LVY8_SYNAS
Syntrophus aciditrophicus (strain SB)
186
0
20451
TrEMBL
-
Q2LVY6_SYNAS
Syntrophus aciditrophicus (strain SB)
263
0
29063
TrEMBL
-
A0A192C6Z0_ECOLX
223
4
26192
TrEMBL
-
Q165C3_ROSDO
Roseobacter denitrificans (strain ATCC 33942 / OCh 114)
198
0
21300
TrEMBL
-
C7C9E7_METED
Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)
980
0
107730
TrEMBL
-
A0A2E1M9V0_9PROT
270
0
30063
TrEMBL
-
E2XH07_SHIDY
195
0
21511
TrEMBL
-
A0A0E1CM59_KLEPN
211
4
24703
TrEMBL
-
A0A2E5KI58_9CHLR
109
0
11754
TrEMBL
-
C7C9E8_METED
Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)
198
0
21673
TrEMBL
-
Q2LQE5_SYNAS
Syntrophus aciditrophicus (strain SB)
265
0
29486
TrEMBL
-
A0A2D5PPJ9_9GAMM
182
0
20147
TrEMBL
-
A0A7V8LTX4_9MYCO
384
0
41924
TrEMBL
-
A0A090NXE3_SHIDY
809
0
90017
TrEMBL
-
A0A0A7A0L9_SHIDY
195
0
21456
TrEMBL
-
A0A2E6XK06_9GAMM
197
0
21697
TrEMBL
-
Q5E542_ALIF1
Aliivibrio fischeri (strain ATCC 700601 / ES114)
202
0
21866
TrEMBL
-
A0A192CEV2_ECOLX
211
4
24606
TrEMBL
-
A0A090NBT9_SHIDY
195
0
21511
TrEMBL
-
A0A090NDV2_SHIDY
223
4
26139
TrEMBL
-
W8UZI8_KLEPN
803
0
89932
TrEMBL
-
A0A658T9J6_9MYCO
57
0
6150
TrEMBL
-
A0A2I2J3L4_9ACTO
396
0
43355
TrEMBL
-
A0A090NHC7_SHIDY
211
4
24606
TrEMBL
-
A0A090NDU5_SHIDY
601
0
67660
TrEMBL
-
A0A3S4I5G9_9GAMM
103
0
11630
TrEMBL
-
A0A7U4LPR5_BURCE
386
0
41761
TrEMBL
-
A0A192CFC9_ECOLX
804
0
89598
TrEMBL
-
A0A7U9JEP6_9BURK
386
0
41761
TrEMBL
-
H0FU26_RHIML
75
0
7874
TrEMBL
-
A0A7G4RHJ1_9GAMM
319
0
35243
TrEMBL
-
A0A447SYY8_9GAMM
171
0
19575
TrEMBL
-
A0A2E5Y7C2_9GAMM
386
0
42435
TrEMBL
-
W8USU7_KLEPN
195
0
21340
TrEMBL
-
W8VIH2_KLEPN
804
0
89363
TrEMBL
-
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addition of sodium dithionite stabilizes the enzyme
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663912
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Graham, A.; Boxer, D.H.
The organization of formate dehydrogenase in the cytoplasmic membrane of Escherichia coli
Biochem. J.
195
627-637
1981
Escherichia coli
brenda
Boxer, D.; Malcolm, A.; Graham, A.
Escherichia coli formate to nitrate respiratory pathway: structural analysis
Biochem. Soc. Trans.
10
480-481
1982
Escherichia coli
brenda
Godfrey, C.; Coddington, A.
Purification and properties of formate dehydrogenase from Pseudomonas aeruginosa
Biochem. J.
243
225 - 233
1987
Pseudomonas aeruginosa, Pseudomonas aeruginosa NCTC 6750
brenda
Lueke, I.; Butland, G.; Moore, K.; Buchanan, G.; Lyall, V.; Fairhurst, S.A.; Greenblatt, J.F.; Emili, A.; Palmer, T.; Sargent, F.
Biosynthesis of the respiratory formate dehydrogenases from Escherichia coli: characterization of the FdhE protein
Arch. Microbiol.
190
685-696
2008
Escherichia coli
brenda
Gale, E.F.
Formic dehydrogenase of bacterium coli: its inactivation by oxygen and its protection in the bacterial cell
Biochem. J.
33
1012-1027
1939
Escherichia coli
brenda
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