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Information on EC 1.2.1.B25 - long-chain-fatty-acyl-CoA reductase and Organism(s) Arabidopsis thaliana and UniProt Accession Q39152

for references in articles please use BRENDA:EC1.2.1.B25
preliminary BRENDA-supplied EC number
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Arabidopsis thaliana
UNIPROT: Q39152 not found.
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
Acr, aldehyde-forming fatty acyl-CoA reductase, cACR, cyanobacterial acyl-CoA reductase, FAR1, FAR4, FAR5, FAR6, long-chain ACR, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
long-chain-aldehyde:NADP+ oxidoreductase
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a long-chain fatty acyl-CoA + NADPH + H+
a long-chain aldehyde + CoA + NADP+
show the reaction diagram
recombinant protein produces C18:0 and C22:0 fatty alcohols, C16:0-OH, C20:0-OH, and C24:0-OH also detectable
aldehyde intermediate is immediately reduced into the corresponding alcohol, chain lengths of primary alcohols produced by FAR heterologous expression in yeast are consistent with the chain lengths of primary alcohols found in Arabidopsis suberin
-
?
a long-chain fatty acyl-CoA + NADPH + H+
a long-chain aldehyde + CoA + NADP+
show the reaction diagram
additional information
?
-
detailed analysis of FAR6 gene promotor
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
slight accumulation
Manually annotated by BRENDA team
young and mature one
Manually annotated by BRENDA team
slight accumulation
Manually annotated by BRENDA team
slight accumulation in developing ones
Manually annotated by BRENDA team
gene expressed predominantly
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
enzyme is responsible for generating primary fatty alcohols associated with suberin biosynthesis
metabolism
enzyme is responsible for generating primary fatty alcohols associated with suberin biosynthesis
physiological function
observations reveal the association of the FAR6 gene with wound response
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FACR1_ARATH
491
0
55481
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
open reading frame subcloned into yeast expression vector pVT102U Saccharomyces cerevisiae
open reading frame subcloned into yeast expression vector pVT102U Saccharomyces cerevisiae
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
FAR1 transcript detectable by RT-PCR at 1 h after wounding and peaks at 48 h and remained high after 96 h, further induction after 4 h at salt concentrations of 50, 100, and 200 mM NaCl - FAR1 levels remain induced at 24 h only in the presence of 200 mM NaCl
expression is induced by wounding in the epidermal layer of mature stem internodes, transcript levels increase more than 2fold after 30 min of wounding
FAR4 transcript detectable by RT-PCR at 24 h after wounding and peaks at 48 h and remained high after 96 h, further induction after 4 h at salt concentrations of 50, 100, and 200 mM NaCl - induced expression levels remain high after 24 h at all three salt concentrations
FAR5 transcript detectable by RT-PCR at 1 h after wounding and peaks at 48 h and remained high after 96 h, further induction after 4 h at salt concentrations of 50, 100, and 200 mM NaCl - induced expression levels remain high after 24 h at all three salt concentrations
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Domergue, F.; Vishwanath, S.; Joubes, J.; Ono, J.; Lee, J.; Bourdon, M.; Alhattab, R.; Lowe, C.; Pascal, S.; Lessire, R.; Rowland, O.
Three Arabidopsis fatty acyl-coenzyme a reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition
Plant Physiol.
153
1539-1554
2010
Arabidopsis thaliana (Q0WRB0), Arabidopsis thaliana (Q39152), Arabidopsis thaliana (Q9LXN3)
Manually annotated by BRENDA team
Gupta, N.C.; Jain, P.K.; Bhat, S.R.; Srinivasan, R.
Upstream sequence of fatty acyl-CoA reductase (FAR6) of Arabidopsis thaliana drives wound-inducible and stem-specific expression
Plant Cell Rep.
31
839-850
2012
Arabidopsis thaliana (B9TSP7)
Manually annotated by BRENDA team