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Information on EC 1.2.1.99 - 4-(gamma-glutamylamino)butanal dehydrogenase

for references in articles please use BRENDA:EC1.2.1.99

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IUBMB Comments

The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC 1.2.1.19, aminobutyraldehyde dehydrogenase, and EC 1.2.1.24, succinate-semialdehyde dehydrogenase (NAD+).

The enzyme appears in viruses and cellular organisms

Synonyms
ALDH, gamma-Glu-gamma-aminobutyraldehyde dehydrogenase, gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [NAD(P)+], NAD+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase, PuuC, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4-(gamma-L-glutamylamino)butanal + NAD(P)+ + H2O = 4-(gamma-L-glutamylamino)butanoate + NAD(P)H + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
putrescine degradation II
Highest Expressing Human Cell Lines
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