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Enzyme Nomenclature
Information on EC 1.2.1.96 - 4-hydroxybenzaldehyde dehydrogenase (NADP+)
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
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EC NUMBER 
COMMENTARY 
1.2.1.96
-
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RECOMMENDED NAME
GeneOntology No.
4-hydroxybenzaldehyde dehydrogenase (NADP+)
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dehydrogenation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
4-hydroxybenzaldehyde:NADP+ oxidoreductase
Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxy-3-methylbenzaldehyde + NAD+ + H2O
4-hydroxy-3-methylbenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
-
-
?
4-hydroxy-3-methylbenzaldehyde + NAD+ + H2O
4-hydroxy-3-methylbenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
-
-
?
4-hydroxy-3-methylbenzaldehyde + NADP+ + H2O
4-hydroxy-3-methylbenzoic acid + NADPH + H+
-
-
-
?
4-hydroxy-3-methylbenzaldehyde + NADP+ + H2O
4-hydroxy-3-methylbenzoic acid + NADPH + H+
-
-
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
-
-
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
-
-
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
-
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
-
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
involved in the degradation pathway of toluene
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
involved in the degradation pathway of toluene
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
involved in the degradation pathway of p-cresol
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
-
-
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
-
-
-
?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
-
-
-
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
involved in the degradation pathway of toluene
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
involved in the degradation pathway of toluene
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
-
involved in the degradation pathway of p-cresol
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
Q59702
-
-
-
?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
Q59702
-
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00636
4-hydroxy-3-methylbenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.02055
4-hydroxy-3-methylbenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
0.00357
4-hydroxybenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.01311
4-hydroxybenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.0017
4-hydroxy-3-methylbenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
0.071
4-hydroxy-3-methylbenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.0017
4-hydroxybenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
0.26
4-hydroxybenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.083
4-hydroxy-3-methylbenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
11.16
4-hydroxy-3-methylbenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.13
4-hydroxybenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
72.83
4-hydroxybenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
high expression in normal hairy root, activity is 15fold lower in green hairy root
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 1.2.1.96)
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