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Information on EC 1.2.1.96 - 4-hydroxybenzaldehyde dehydrogenase (NADP+) for references in articles please use BRENDA:EC1.2.1.96
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EC Tree
IUBMB Comments Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
p-hydroxybenzaldehyde dehydrogenase, PchA, PHBDD, PHBZ,
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p-hydroxybenzaldehyde dehydrogenase
p-hydroxybenzaldehyde dehydrogenase
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ambiguous
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p-hydroxybenzaldehyde dehydrogenase
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p-hydroxybenzaldehyde dehydrogenase
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p-hydroxybenzaldehyde dehydrogenase
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p-hydroxybenzaldehyde dehydrogenase
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PchA
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gene name
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PHBDD
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PHBZ
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4-hydroxybenzaldehyde + NADP+ + H2O = 4-hydroxybenzoate + NADPH + 2 H+
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dehydrogenation
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4-hydroxybenzaldehyde:NADP+ oxidoreductase
Involved in the aerobic pathway for degradation of toluene, 4-methylphenol, and 2,4-xylenol by several Pseudomonas strains. The enzyme is also active with 4-hydroxy-3-methylbenzaldehyde. cf. EC 1.2.1.64, 4-hydroxybenzaldehyde dehydrogenase (NAD+).
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4-hydroxy-3-methylbenzaldehyde + NAD+ + H2O
4-hydroxy-3-methylbenzoic acid + NADH + H+
4-hydroxy-3-methylbenzaldehyde + NADP+ + H2O
4-hydroxy-3-methylbenzoic acid + NADPH + H+
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoic acid + NADH + H+
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
4-hydroxy-3-methylbenzaldehyde + NAD+ + H2O
4-hydroxy-3-methylbenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
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4-hydroxy-3-methylbenzaldehyde + NAD+ + H2O
4-hydroxy-3-methylbenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
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4-hydroxy-3-methylbenzaldehyde + NADP+ + H2O
4-hydroxy-3-methylbenzoic acid + NADPH + H+
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4-hydroxy-3-methylbenzaldehyde + NADP+ + H2O
4-hydroxy-3-methylbenzoic acid + NADPH + H+
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4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
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?
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoic acid + NADH + H+
low activity with NAD+ as cosubstrate
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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involved in the degradation pathway of toluene
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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involved in the degradation pathway of toluene
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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involved in the degradation pathway of p-cresol
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
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4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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4-hydroxybenzaldehyde + NAD+ + H2O
4-hydroxybenzoate + NADH + H+
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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involved in the degradation pathway of toluene
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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involved in the degradation pathway of toluene
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?
4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoate + NADPH + H+
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involved in the degradation pathway of p-cresol
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
Q59702
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4-hydroxybenzaldehyde + NADP+ + H2O
4-hydroxybenzoic acid + NADPH + H+
Q59702
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NADP+
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4fold greater oxidation than with NAD+
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0.00636 - 0.02055
4-hydroxy-3-methylbenzaldehyde
0.00357 - 0.01311
4-hydroxybenzaldehyde
0.00636
4-hydroxy-3-methylbenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.02055
4-hydroxy-3-methylbenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
0.00357
4-hydroxybenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.01311
4-hydroxybenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
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0.0017 - 0.071
4-hydroxy-3-methylbenzaldehyde
0.0017 - 0.26
4-hydroxybenzaldehyde
0.0017
4-hydroxy-3-methylbenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
0.071
4-hydroxy-3-methylbenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.0017
4-hydroxybenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
0.26
4-hydroxybenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
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0.083 - 11.16
4-hydroxy-3-methylbenzaldehyde
0.13 - 72.83
4-hydroxybenzaldehyde
0.083
4-hydroxy-3-methylbenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
11.16
4-hydroxy-3-methylbenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
0.13
4-hydroxybenzaldehyde
with NAD+ as cosubstrate, at pH 8.0 and 30°C
72.83
4-hydroxybenzaldehyde
with NADP+ as cosubstrate, at pH 8.0 and 30°C
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SwissProt
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SwissProt
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strains NCIMB 9866 and 9869
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high expression in normal hairy root, activity is 15fold lower in green hairy root
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PCHA_PSEPU
491
0
53156
Swiss-Prot
A0A290HC49_9PROT
481
0
51887
TrEMBL
A0A395L9K7_9RHIZ
461
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50346
TrEMBL
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Ni2+-NTA column chromatography
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expressed in Escherichia coli BL21(DE3) cells
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Cronin, C.N.; Kim, J.; Fuller, J.H.; Zhang, X.; McIntire, W.S.
Organization and sequences of p-hydroxybenzaldehyde dehydrogenase and other plasmid-encoded genes for early enzymes of the p-cresol degradative pathway in Pseudomonas putida NCIMB 9866 and 9869
DNA Seq.
10
7-17
1999
Pseudomonas putida
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Whited, G.M.; Gibson, D.T.
Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1
J. Bacteriol.
173
3017-3020
1991
Pseudomonas mendocina, Pseudomonas mendocina KR1
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Chen, Y.F.; Chao, H.; Zhou, N.Y.
The catabolism of 2,4-xylenol and p-cresol share the enzymes for the oxidation of para-methyl group in Pseudomonas putida NCIMB 9866
Appl. Microbiol. Biotechnol.
98
1349-1356
2014
Pseudomonas putida (Q59702), Pseudomonas putida NCIMB 9866 (Q59702)
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Miller Jr, E.S.; Peretti, S.W.
Bioconversion of toluene to p-hydroxybenzoate via the construction and characterization of a recombinant Pseudomonas putida
Green Chem.
1
143-152
1999
Pseudomonas putida, Pseudomonas putida EM2839
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Mukherjee, C.; Samanta, T.; Mitra, A.
Redirection of metabolite biosynthesis from hydroxybenzoates to volatile terpenoids in green hairy roots of Daucus carota
Planta
243
305-320
2016
Daucus carota
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1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)
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