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Information on EC 1.2.1.85 - 2-hydroxymuconate-6-semialdehyde dehydrogenase

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IUBMB Comments
This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds. Has lower activity with benzaldehyde . Activity with NAD+ is more than 10-fold higher than with NADP+ . cf. EC 1.2.1.32, aminomuconate-semialdehyde dehydrogenase.
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The enzyme appears in viruses and cellular organisms
Synonyms
hms dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-hydroxymuconate-6-semialdehyde + NAD+ + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+
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