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EC Tree
IUBMB Comments The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
The enzyme appears in viruses and cellular organisms
Synonyms
ALD , SapD,
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ALD
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SapD
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4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
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4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
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4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
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4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
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additional information
no cofactor: NAD+
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additional information
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no cofactor: NAD+
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UniProt
brenda
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UniProt
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physiological function
an enzyme deletion strain is still able to grow on pseudoxynicotine, the cell growth and the rate of pseudoxynicotine removal are initially slightly reduced. After the deletion strain is cultured with pseudoxynicotine for several generations, the pseudoxynicotine degradation characteristics reach the wild-type level
physiological function
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an enzyme deletion strain is still able to grow on pseudoxynicotine, the cell growth and the rate of pseudoxynicotine removal are initially slightly reduced. After the deletion strain is cultured with pseudoxynicotine for several generations, the pseudoxynicotine degradation characteristics reach the wild-type level
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expression in Escherichia coli
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Qiu, J.; Ma, Y.; Wen, Y.; Chen, L.; Wu, L.; Liu, W.
Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine
Appl. Environ. Microbiol.
78
2154-2160
2012
Pseudomonas sp. (H8ZPX2), Pseudomonas sp., Pseudomonas sp. HZN6 (H8ZPX2)
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Enzyme Nomenclature
1.2.1.83 3-succinoylsemialdehyde-pyridine dehydrogenase
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