Information on EC 1.2.1.83 - 3-succinoylsemialdehyde-pyridine dehydrogenase

for references in articles please use BRENDA:EC1.2.1.83
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The expected taxonomic range for this enzyme is: Pseudomonas

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EC NUMBER
COMMENTARY hide
1.2.1.83
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RECOMMENDED NAME
GeneOntology No.
3-succinoylsemialdehyde-pyridine dehydrogenase
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REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
nicotine degradation II (pyrrolidine pathway)
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nicotine degradation IV
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Nicotinate and nicotinamide metabolism
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
4-oxo-4-(pyridin-3-yl)butanal:NADP+ oxidoreductase
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6. It participates in the nicotine degradation pathway.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
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LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-oxo-4-(pyridin-3-yl)butanal + NADP+ + H2O
4-oxo-4-(pyridin-3-yl)butanoate + NADPH + H+
show the reaction diagram
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
specific for NADP+
additional information
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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Show AA Sequence (214 entries)
Please use the Sequence Search for a specific query.
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LINKS TO OTHER DATABASES (specific for EC-Number 1.2.1.83)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)