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Information on EC 1.2.1.81 - sulfoacetaldehyde dehydrogenase (acylating) for references in articles please use BRENDA:EC1.2.1.81
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EC Tree
IUBMB Comments The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.
The expected taxonomic range for this enzyme is: Cupriavidus necator
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SauS
-
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2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+
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-
-
-
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2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)
The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.
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2-sulfoacetaldehyde + CoA + NADP+
sulfoacetyl-CoA + NADPH + H+
sulfoacetyl-CoA + NADPH + H+
2-sulfoacetaldehyde + CoA + NADP+
2-sulfoacetaldehyde + CoA + NADP+
sulfoacetyl-CoA + NADPH + H+
specific for NADP+, no activity with NAD+. The enzyme is specific for sulfoacetaldehyde. No activity with: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid
-
-
r
2-sulfoacetaldehyde + CoA + NADP+
sulfoacetyl-CoA + NADPH + H+
specific for NADP+, no activity with NAD+. The enzyme is specific for sulfoacetaldehyde. No activity with: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid
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-
r
sulfoacetyl-CoA + NADPH + H+
2-sulfoacetaldehyde + CoA + NADP+
the enzyme is involved in degradation of sulfoacetate
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-
?
sulfoacetyl-CoA + NADPH + H+
2-sulfoacetaldehyde + CoA + NADP+
the enzyme is involved in degradation of sulfoacetate
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-
?
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sulfoacetyl-CoA + NADPH + H+
2-sulfoacetaldehyde + CoA + NADP+
sulfoacetyl-CoA + NADPH + H+
2-sulfoacetaldehyde + CoA + NADP+
Q0K845
the enzyme is involved in degradation of sulfoacetate
-
-
?
sulfoacetyl-CoA + NADPH + H+
2-sulfoacetaldehyde + CoA + NADP+
Q0K845
the enzyme is involved in degradation of sulfoacetate
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-
?
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NADP+
specific for NADP+, no activity with NAD+
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additional information
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no inhibition: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid
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additional information
no inhibition: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid
-
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0.33
2-sulfoacetaldehyde
pH 9.0, temperature not specified in the publication
0.102
CoA
pH 9.0, temperature not specified in the publication
0.064
NADP+
pH 9.0, temperature not specified in the publication
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UniProt
brenda
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UniProt
brenda
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inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction
brenda
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inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction
-
brenda
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malfunction
deletion mutant does not grow on sulfoacetate
malfunction
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deletion mutant does not grow on sulfoacetate
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SAUS_CUPNH
Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)
493
0
51647
Swiss-Prot
A0A1M4PL84_9FIRM
[Clostridium] ultunense Esp
428
0
47074
TrEMBL
A0A375G490_9BURK
485
0
50811
TrEMBL
A0A2S6UQD3_9PROT
473
0
51803
TrEMBL
A0A1V5EAD0_9DELT
463
0
50753
TrEMBL
A0A1X6ZIW8_9RHOB
473
0
49498
TrEMBL
A0A1Y5SQ71_9RHOB
469
0
49220
TrEMBL
A0A2H6IWE8_9BACT
477
0
50596
TrEMBL
A0A238JLA6_9RHOB
471
0
49705
TrEMBL
A0A3N6HSR5_9ACTN
472
0
49621
TrEMBL
A0A3N6GUM9_9ACTN
474
0
49919
TrEMBL
A0A0N7LR76_9RHOB
473
0
49338
TrEMBL
A0A0U1NNA7_9RHOB
461
0
48727
TrEMBL
A0A375IZ70_9BURK
481
0
50585
TrEMBL
A0A1K0IP04_CUPNE
493
0
51471
TrEMBL
A0A1X6Z577_9RHOB
467
0
49346
TrEMBL
A0A1Y5SFS6_9RHOB
469
0
49620
TrEMBL
A0A1R4H3L2_9GAMM
470
0
50809
TrEMBL
A0A375IC76_9BURK
481
0
50688
TrEMBL
A0A0A0HRS8_9RHOB
469
0
49355
TrEMBL
A0A0P1IMJ9_9RHOB
283
0
30784
TrEMBL
A0A1Y5SHM6_9RHOB
466
0
49527
TrEMBL
A0A375GUX5_9BURK
481
0
50658
TrEMBL
A0A0N7MAQ0_9RHOB
473
0
49900
TrEMBL
M1ZFW5_9FIRM
[Clostridium] ultunense Esp
462
0
51007
TrEMBL
A0A2Z2NY54_9GAMM
478
0
50786
TrEMBL
A0A2J7VBD6_9BURK
480
0
50989
TrEMBL
A0A3P3XEW8_9SPIR
497
0
54081
TrEMBL
A0A1X7BVV5_9RHOB
469
0
49259
TrEMBL
M1Z793_9FIRM
[Clostridium] ultunense Esp
754
0
84628
TrEMBL
A0A0P1IKW7_9RHOB
467
0
49294
TrEMBL
A0A0P1G9L7_9RHOB
467
0
49171
TrEMBL
A0A011PYP7_9PROT
465
0
49160
TrEMBL
A0A1M4PL46_9FIRM
[Clostridium] ultunense Esp
372
0
43052
TrEMBL
M1ZB15_9FIRM
[Clostridium] ultunense Esp
465
0
50901
TrEMBL
A0A2S6U954_9PROT
474
0
50182
TrEMBL
A0A2R8C970_9RHOB
469
0
49257
TrEMBL
A0A0H2M740_VARPD
479
0
50373
TrEMBL
A0A212JC49_9DELT
463
0
49877
TrEMBL
A0A2S6TG73_9PROT
442
0
46414
TrEMBL
A0A1X6ZYN3_9RHOB
467
0
49612
TrEMBL
A0A375BML8_9BURK
481
0
50459
TrEMBL
A0A0U5JJZ5_9CLOT
479
0
52732
TrEMBL
A0A1V6A866_9FIRM
466
0
50027
TrEMBL
A0A0P1E8P3_9RHOB
473
0
49287
TrEMBL
A0A1X6YZA5_9RHOB
469
0
49640
TrEMBL
A0A1J5PQT6_9ZZZZ
401
0
42524
TrEMBL
A0A2R8BH07_9RHOB
466
0
49387
TrEMBL
A0A177HC31_9RHOB
469
0
50173
TrEMBL
A0A0D6JJ56_9RHIZ
483
0
52399
TrEMBL
A0A0P1EXY1_9RHOB
467
0
49752
TrEMBL
A0A1X6ZQQ9_9RHOB
467
0
50512
TrEMBL
A0A1J5R6R4_9ZZZZ
480
0
51258
TrEMBL
A0A375EFT5_9BURK
481
0
50339
TrEMBL
A0A1L9NTJ3_9RHOB
467
0
49859
TrEMBL
A0A3R4H0W9_9ZZZZ
125
0
13463
TrEMBL
A0A1V0RQ30_9RHOB
469
0
49461
TrEMBL
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52000
2 * 52000, SDS-PAGE
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dimer
2 * 52000, SDS-PAGE
dimer
-
2 * 52000, SDS-PAGE
-
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4°C or -18°C, 1 week, 30% loss of activity
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inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction
inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction
inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction
-
-
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Weinitschke, S.; Hollemeyer, K.; Kusian, B.; Bowien, B.; Smits, T.H.; Cook, A.M.
Sulfoacetate is degraded via a novel pathway involving sulfoacetyl-CoA and sulfoacetaldehyde in Cupriavidus necator H16
J. Biol. Chem.
285
35249-35254
2010
Cupriavidus necator, Cupriavidus necator (Q0K845), Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1 (Q0K845)
brenda
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1.2.1.81 sulfoacetaldehyde dehydrogenase (acylating)
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