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Information on EC 1.2.1.81 - sulfoacetaldehyde dehydrogenase (acylating)

for references in articles please use BRENDA:EC1.2.1.81

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EC Tree

1 Oxidoreductases

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.1.81 sulfoacetaldehyde dehydrogenase (acylating)

IUBMB Comments

The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.

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The enzyme appears in viruses and cellular organisms

Reaction Schemes

Synonyms

SauS,

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SauS

SauS

SauS

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

Q0K845

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

2-sulfoacetaldehyde + CoA + NADP+ = sulfoacetyl-CoA + NADPH + H+

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PATHWAY SOURCE

PATHWAYS

MetaCyc

sulfoacetate degradation

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SYSTEMATIC NAME

IUBMB Comments

2-sulfoacetaldehyde:NADP+ oxidoreductase (CoA-acetylating)

The enzyme is involved in degradation of sulfoacetate. In this pathway the reaction is catalysed in the reverse direction. The enzyme is specific for sulfoacetaldehyde and NADP+.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-sulfoacetaldehyde + CoA + NADP+

sulfoacetyl-CoA + NADPH + H+

2 entries

sulfoacetyl-CoA + NADPH + H+

2-sulfoacetaldehyde + CoA + NADP+

2 entries

2-sulfoacetaldehyde + CoA + NADP+

sulfoacetyl-CoA + NADPH + H+

Cupriavidus necator

Q0K845

specific for NADP+, no activity with NAD+. The enzyme is specific for sulfoacetaldehyde. No activity with: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid

709139

2-sulfoacetaldehyde + CoA + NADP+

sulfoacetyl-CoA + NADPH + H+

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

Q0K845

709139

sulfoacetyl-CoA + NADPH + H+

2-sulfoacetaldehyde + CoA + NADP+

Cupriavidus necator

Q0K845

the enzyme is involved in degradation of sulfoacetate

709139

sulfoacetyl-CoA + NADPH + H+

2-sulfoacetaldehyde + CoA + NADP+

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

Q0K845

the enzyme is involved in degradation of sulfoacetate

709139

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

sulfoacetyl-CoA + NADPH + H+

2-sulfoacetaldehyde + CoA + NADP+

2 entries

sulfoacetyl-CoA + NADPH + H+

2-sulfoacetaldehyde + CoA + NADP+

Cupriavidus necator

Q0K845

the enzyme is involved in degradation of sulfoacetate

709139

sulfoacetyl-CoA + NADPH + H+

2-sulfoacetaldehyde + CoA + NADP+

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

Q0K845

the enzyme is involved in degradation of sulfoacetate

709139

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NADP+

Cupriavidus necator

Q0K845

specific for NADP+, no activity with NAD+

709139

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

2 entries

additional information

Cupriavidus necator

no inhibition: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid

709139

additional information

Cupriavidus necator

Q0K845

no inhibition: acetaldehyde, phosphonoacetaldehyde, glycolaldehyde, formaldehyde, propionaldehyde, succinic semialdehyde, glyoxylate, betaine aldehyde, glyceraldehyde, and 2-oxobutanoic acid

709139

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.33

2-sulfoacetaldehyde

Cupriavidus necator

Q0K845

pH 9.0, temperature not specified in the publication

709139

0.102

CoA

Cupriavidus necator

Q0K845

pH 9.0, temperature not specified in the publication

709139

0.064

NADP+

Cupriavidus necator

Q0K845

pH 9.0, temperature not specified in the publication

709139

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Cupriavidus necator

709139

Q0K845

UniProt

brenda

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

709139

Q0K845

UniProt

brenda

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

culture condition:2-sulfoacetate-grown cell

2 entries

culture condition:2-sulfoacetate-grown cell

Cupriavidus necator

Q0K845

inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction

709139

brenda

culture condition:2-sulfoacetate-grown cell

Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1

inducible activity. Extracts of acetate-, taurine-, or isethionate-grown cells show no activity, extracts of sulfoacetate-grown cells catalyze the reaction

brenda

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

2 entries

malfunction