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Information on EC 1.2.1.76 - succinate-semialdehyde dehydrogenase (acylating)

for references in articles please use BRENDA:EC1.2.1.76

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IUBMB Comments

Catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde. The enzyme has been described in Clostridium kluyveri, where it participates in succinate fermentation ), and in Metallosphaera sedula, where it participates in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [2,3].

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
Tneu_0421, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
succinate semialdehyde + CoA + NADP+ = succinyl-CoA + NADPH + H+
show the reaction diagram
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