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Enzyme Nomenclature
Information on EC 1.2.1.73 - sulfoacetaldehyde dehydrogenase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.2.1.73
-
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RECOMMENDED NAME
GeneOntology No.
sulfoacetaldehyde dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-sulfoacetaldehyde + H2O + NAD+ = sulfoacetate + NADH + 2 H+
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
2-sulfoacetaldehyde:NAD+ oxidoreductase
This reaction is part of a bacterial pathway that can utilize the amino group of taurine as a sole source of nitrogen for growth. At physiological concentrations, NAD+ cannot be replaced by NADP+. The enzyme is specific for sulfoacetaldehyde, as formaldehyde, acetaldehyde, betaine aldehyde, propanal, glyceraldehyde, phosphonoacetaldehyde, glyoxylate, glycolaldehyde and 2-oxobutyrate are not substrates.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
formerly Oceanospirillum sp., CCUG 52065, a marine gammaproteobacterium, strain MED92, gene safD encoding an inducible enzyme
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-sulfoacetaldehyde + H2O + NAD(P)+
sulfoacetate + NAD(P)H + H+
-
the enzyme is specific for sulfoacetaldehyde, NAD+ is the highly preferred cofactor to NADP+
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-
?
additional information
?
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-
the organism assimilates taurine-nitrogen and excrete sulfoacetate. The pathway involved an ABC transporter, taurine:pyruvate aminotransferase, a sulfoacetaldehyde dehydrogenase, and exporter(s) of sulfoacetate, overview
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2-sulfoacetaldehyde + H2O + NAD(P)+
sulfoacetate + NADH + H+
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NAD+ is the highly preferred cofactor
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-
?
2-sulfoacetaldehyde + H2O + NAD(P)+
sulfoacetate + NADH + H+
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NAD+ is the highly preferred cofactor
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-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
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-
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
-
-
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
-
sulfoacetaldehyde is derived from taurine by taurine dehydrogenase, overview
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
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-
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
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sulfoacetaldehyde is derived from taurine by taurine dehydrogenase, overview
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-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
the organism assimilates taurine-nitrogen and excrete sulfoacetate. The pathway involved an ABC transporter, taurine:pyruvate aminotransferase, a sulfoacetaldehyde dehydrogenase, and exporter(s) of sulfoacetate, overview
-
-
-
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
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-
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
-
-
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
-
sulfoacetaldehyde is derived from taurine by taurine dehydrogenase, overview
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
-
-
-
-
?
2-sulfoacetaldehyde + H2O + NAD+
sulfoacetate + NADH + H+
-
sulfoacetaldehyde is derived from taurine by taurine dehydrogenase, overview
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-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.2 - 10.5
-
50% of maximal activity at pH 7.2, 70% at pH 8.0, and 80% at pH 9.5-10.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
22
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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growth with taurine (2-aminoethanesulfonate) as the sole source of combined nitrogen under aerobic conditions
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growth with taurine (2-aminoethanesulfonate) as the sole source of combined nitrogen under aerobic conditions
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
native enzyme 610fold to homogeneity by anion exchange and hydrophobic interaction chromatography
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene safD, DNA and amino acid sequence determination and analysis, genetic organization
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
analysis
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the enzyme is useful for determination of sulfoacetaldehyde concentrations
analysis
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the enzyme is useful for determination of sulfoacetaldehyde concentrations
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LINKS TO OTHER DATABASES (specific for EC-Number 1.2.1.73)
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