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Information on EC 1.2.1.59 - glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) and Organism(s) Clostridium acetobutylicum and UniProt Accession O52631

for references in articles please use BRENDA:EC1.2.1.59
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IUBMB Comments
NAD+ and NADP+ can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and EC 1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), which are NAD+- and NADP+-dependent, respectively.
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This record set is specific for:
Clostridium acetobutylicum
UNIPROT: O52631
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Word Map
The taxonomic range for the selected organisms is: Clostridium acetobutylicum
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
gapdh, glyceraldehyde-3-phosphate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, chloroplast glyceraldehyde-3-phosphate dehydrogenase, nadp-dependent glyceraldehyde-3-phosphate dehydrogenase, gapdh2, phosphorylating glyceraldehyde-3-phosphate dehydrogenase, gbs gapdh, nadp-dependent glyceraldehyde 3-phosphate dehydrogenase, nadp-dependent glyceraldehydephosphate dehydrogenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NADP-dependent glyceraldehyde-3-phosphate dehydrogenase
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Dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide (phosphate))
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GAPDH
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GAPDH2
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Glyceraldehyde-3-phosphate dehydrogenase (NAD(P))
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NAD(NADP)-dependent glyceraldehyde-3-phosphate dehydrogenase
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NAD(P)-dependent G3P dehydrogenase
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NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
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Triosephosphate dehydrogenase (NAD(P))
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)
NAD+ and NADP+ can be used as cofactors with similar efficiency, unlike EC 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) and EC 1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating), which are NAD+- and NADP+-dependent, respectively.
CAS REGISTRY NUMBER
COMMENTARY hide
39369-25-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glyceraldehyde 3-phosphate + phosphate + NAD+
3-phospho-D-glyceroyl phosphate + NADH + H+
show the reaction diagram
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D-glyceraldehyde 3-phosphate + phosphate + NADP+
3-phospho-D-glyceroyl phosphate + NADPH + H+
show the reaction diagram
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glyceraldehyde 3-phosphate + phosphate + NAD+
3-phospho-D-glyceroyl phosphate + NADH + H+
show the reaction diagram
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-
?
D-glyceraldehyde 3-phosphate + phosphate + NADP+
3-phospho-D-glyceroyl phosphate + NADPH + H+
show the reaction diagram
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene gapC, recombinant overexpression in Corynebacterium glutamicum strain ATCC 13032, coexpression with Bacillus subtilis gene rocG encoding NAD+-dependent glutamate dehydrogenase, leading to increased L-ornithine biosynthesis in the engineered strain, overview. Quantitative real-time PCR expression analysis. Effects of overexpression of genes encoding enzymes in the upstream pathway of glutamate biosynthesis on L-ornithine production in Corynebacterium glutamicum DELTAAP. Overexpression of Clostridium acetobutylicum gapC increases the production of CoQ10
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jiang, L.; Zhang, Y.; Li, Z.; Liu, J.
Metabolic engineering of Corynebacterium glutamicum for increasing the production of L-ornithine by increasing NADPH availability
J. Ind. Microbiol. Biotechnol.
40
1143-1151
2013
Clostridium acetobutylicum (O52631), Clostridium acetobutylicum
Manually annotated by BRENDA team