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Information on EC 1.2.1.44 - cinnamoyl-CoA reductase and Organism(s) Medicago truncatula and UniProt Accession G7JEE5

for references in articles please use BRENDA:EC1.2.1.44
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IUBMB Comments
Acts also on a number of substituted cinnamoyl esters of coenzyme A.
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This record set is specific for:
Medicago truncatula
UNIPROT: G7JEE5
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Word Map
The taxonomic range for the selected organisms is: Medicago truncatula
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
cinnamoyl-coa reductase, cinnamoyl coa reductase, ll-ccrh1, bpccr1, cinnamoyl-coa reductase 1, ta-ccr2, sbccr1, atccr1, osccr1, sbccr2-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cinnamoyl-CoA reductase1
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CCR1
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isoform
cinnamoyl CoA reductase
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cinnamoyl-CoA reductase2
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cinnamoyl-CoA:NADPH reductase
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-
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cinnamoyl-coenzyme A reductase
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-
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feruloyl coenzyme A reductase
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-
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feruloyl-CoA reductase
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-
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ferulyl-CoA reductase
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-
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p-hydroxycinnamoyl coenzyme A reductase
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-
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reductase, cinnamoyl coenzyme A
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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reduction
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SYSTEMATIC NAME
IUBMB Comments
cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)
Acts also on a number of substituted cinnamoyl esters of coenzyme A.
CAS REGISTRY NUMBER
COMMENTARY hide
59929-39-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-coumaroyl-CoA + NADPH + H+
4-coumaraldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
caffeoyl-CoA + NADPH + H+
caffealdehyde + CoA + NADP+
show the reaction diagram
cinnamoyl-CoA + NADPH + H+
cinnamaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
feruloyl-CoA + NADPH + H+
coniferaldehyde + CoA + NADP+
show the reaction diagram
sinapoyl-CoA + NADPH + H+
sinapaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
4-coumaroyl-CoA + NADPH + H+
4-coumaraldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
5-hydroxyferuloyl-CoA + NADPH + H+
5-hydroxyconiferaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
-
?
caffeoyl-CoA + NADPH + H+
caffealdehyde + CoA + NADP+
show the reaction diagram
coumaroyl-CoA + NADPH + H+
coumaric aldehyde + CoA + NADP+
show the reaction diagram
-
preferred substrate for isoform CCR2
-
-
?
feruloyl-CoA + NADPH + H+
coniferaldehyde + CoA + NADP+
show the reaction diagram
sinapoyl-CoA + NADPH + H+
sinapaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
-
?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-coumaroyl-CoA + NADPH + H+
4-coumaraldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
caffeoyl-CoA + NADPH + H+
caffealdehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
cinnamoyl-CoA + NADPH + H+
cinnamaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
feruloyl-CoA + NADPH + H+
coniferaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
sinapoyl-CoA + NADPH + H+
sinapaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
4-coumaroyl-CoA + NADPH + H+
4-coumaraldehyde + CoA + NADP+
show the reaction diagram
-
-
-
r
5-hydroxyferuloyl-CoA + NADPH + H+
5-hydroxyconiferaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
-
?
caffeoyl-CoA + NADPH + H+
caffealdehyde + CoA + NADP+
show the reaction diagram
coumaroyl-CoA + NADPH + H+
coumaric aldehyde + CoA + NADP+
show the reaction diagram
-
preferred substrate for isoform CCR2
-
-
?
feruloyl-CoA + NADPH + H+
coniferaldehyde + CoA + NADP+
show the reaction diagram
sinapoyl-CoA + NADPH + H+
sinapaldehyde + CoA + NADP+
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
binding structure analysis. Structural comparisons of the NADP+-complexed form of Ph-CCR1 with the apo forms of both Ph-CCR1 and Medicago trunculata Mt-CCR2 reveals a number of adjustments that are localized to polypeptide chain segments surrounding the central cleft and are undoubtedly a direct consequence of NADP+ binding
NADPH
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase are key enzymes of monolignol biosynthesis. It is likely that Mt-CCR1 is the major CCR isozyme involved in lignin biosynthesis, and Mt-CCR2 is proposed to be involved in an alternative route for S lignin biosynthesis in Medicago truncatula
malfunction
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Ccr1 knockout mutants exhibit a dramatic decrease in S lignin in vascular tissue
metabolism
cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase are key enzymes of monolignol biosynthesis. It is likely that Mt-CCR1 is the major CCR isozyme involved in lignin biosynthesis, and Mt-CCR2 is proposed to be involved in an alternative route for S lignin biosynthesis in Medicago truncatula
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
G7JEE5_MEDTR
336
0
37202
TrEMBL
other Location (Reliability: 2)
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 (DE34) cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
knockout of caffeoyl CoA 3-O-methyltransferase up-regulates isoform CCR2
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
potential exploitation of rationally engineered forms of CCR and CAD2 for the targeted modification of monolignol composition in transgenic plants
synthesis
potential exploitation of rationally engineered forms of CCR and CAD2 for the targeted modification of monolignol composition in transgenic plants
biotechnology
potential exploitation of rationally engineered forms of CCR and CAD2 for the targeted modification of monolignol composition in transgenic plants
synthesis
potential exploitation of rationally engineered forms of CCR and CAD2 for the targeted modification of monolignol composition in transgenic plants
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhou, R.; Jackson, L.; Shadle, G.; Nakashima, J.; Temple, S.; Chen, F.; Dixon, R.A.
Distinct cinnamoyl CoA reductases involved in parallel routes to lignin in Medicago truncatula
Proc. Natl. Acad. Sci. USA
107
17803-17808
2010
Medicago truncatula
Manually annotated by BRENDA team
Pan, H.; Zhou, R.; Louie, G.V.; Muehlemann, J.K.; Bomati, E.K.; Bowman, M.E.; Dudareva, N.; Dixon, R.A.; Noel, J.P.; Wang, X.
Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis
Plant Cell
26
3709-3727
2014
Medicago truncatula, Medicago truncatula (G7JEE5), Petunia x hybrida (A0A059TC02), Petunia x hybrida
Manually annotated by BRENDA team