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Information on EC 1.2.1.3 - aldehyde dehydrogenase (NAD+) and Organism(s) Homo sapiens

for references in articles please use BRENDA:EC1.2.1.3
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EC Tree
IUBMB Comments
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
ADH, AdhE, AHD-M1, ALD1A1, ALD4, ALDDH, aldehyde dehydrogenase, aldehyde dehydrogenase (NAD), aldehyde dehydrogenase 1, aldehyde dehydrogenase 1A1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AHD-M1
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ALD1A1
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isoform
ALDDH
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aldehyde dehydrogenase 1
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aldehyde dehydrogenase 1A1
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isoform
aldehyde dehydrogenase 1A3
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aldehyde dehydrogenase 1B1
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isoform
aldehyde dehydrogenase 2
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aldehyde dehydrogenase 7A1
aldehyde dehydrogenase class 1
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aldehyde dehydrogenase type 2
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Aldehyde dehydrogenase [NAD+]
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Aldehyde dehydrogenase, cytosolic
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Aldehyde dehydrogenase, microsomal
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aldehyde dehydrogenase-2
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aldehyde:NAD+ oxidoreductase
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ALDH 2
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ALDH I
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ALDH II
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ALDH-2
ALDH-E1
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ALDH-E2
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ALDH1
ALDH1-NL
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ALDH1A1
Aldh1a3
Aldh1b1
ALDH2
ALDH2(2)
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mutant enzyme
ALDH3A1
ALDH3A2
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isozyme
Aldh3b1
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isozyme
Aldh7a1
ALDHI
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ALDHX
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ALHDII
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Allergen Alt a 10
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benzaldehyde dehydrogenase
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Brassica turgor-responsive/drought-induced gene 26 protein
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Btg-26
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class 1 aldehyde dehydrogenase
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class 2 aldehyde dehydrogenase
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CoA-independent aldehyde dehydrogenase
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ETA-crystallin
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gamma-aminobutyraldehyde dehydrogenase
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hALDH2
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K(+)-ACDH
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K(+)-activated acetaldehyde dehydrogenase
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m-methylbenzaldehyde dehydrogenase
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Matured fruit 60 kDa protein
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MF-60
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Mg(2+)-ACDH
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Mg(2+)-activated acetaldehyde dehydrogenase
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mitochondrial aldehyde dehydrogenase
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NAD+-linked aldehyde dehydrogenase
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NAD-aldehyde dehydrogenase
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NAD-dependent 4-hydroxynonenal dehydrogenase
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NAD-dependent aldehyde dehydrogenase
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NAD-linked aldehyde dehydrogenase
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Non-lens ALDH1
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P51
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PM-ALDH9
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propionaldehyde dehydrogenase
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R-aminobutyraldehyde dehydrogenase
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RALDH
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RALDH(II)
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RalDH1
Retinal dehydrogenase
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retinal dehydrogenase type I
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sALDH
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salvery aldehyde dehydrogenase
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Turgor-responsive protein 26G
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an aldehyde + NAD+ + H2O = a carboxylate + NADH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
redox reaction
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-
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reduction
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
aldehyde:NAD+ oxidoreductase
Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
CAS REGISTRY NUMBER
COMMENTARY hide
9028-86-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-N-(3-(6-(4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b] thiophene-2-carboxamide + H2O + O2
?
show the reaction diagram
-
i.e. GDC-0834, a Bruton's tyrosine kinase inhibitor, a potential treatment of rheumatoid arthritis. GDC-0834
compound is extensively metabolized by amide hydrolysis by both aldehyde oxidase and carboxylesterase
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?
1-formyl-6-methylpyrene + NAD+
6-methylpyrene 1-carboxylate + NADH + H+
show the reaction diagram
-
-
-
-
?
1-formyl-6-methylpyrene + NAD+ + H2O
6-methylpyrene-1-carboxylic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
1-formyl-8-methylpyrene + NAD+ + H2O
8-methylpyrene-1-carboxylic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
1-formyl-8-methylpyrene + NADP+
8-methylpyrene 1-carboxylate + NADPH + H+
show the reaction diagram
-
-
-
-
?
1-formylpyrene + NAD+
pyrene 1-carboxylate + NADH + H+
show the reaction diagram
-
-
-
-
?
1-formylpyrene + NAD+ + H2O
pyrene-1-carboxylic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
1-naphthaldehyde + NAD+ + H2O
1-naphthoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
2,4-dinitrobenzaldehyde + NAD+ + H2O
2,4-dinitrobenzoate + NADH
show the reaction diagram
-
-
-
-
?
2-formylpyrene + NAD+
pyrene 2-carboxylate + NADH + H+
show the reaction diagram
-
-
-
-
?
2-formylpyrene + NAD+ + H2O
pyrene-2-carboxylic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
2-hydroxy-3-nitrobenzaldehyde + NAD+ + H2O
2-hydroxy-3-nitrobenzoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
2-naphthaldehyde + NAD+ + H2O
2-naphthalene carboxylate + NADH + H+
show the reaction diagram
-
-
-
-
?
2-naphthaldehyde + NAD+ + H2O
2-naphthoate + NADH
show the reaction diagram
-
-
-
-
?
2-naphthaldehyde + NAD+ + H2O
2-naphthoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
2-nonenal + NAD+ + H2O
(E)-non-2-enoate + NADH + H+
show the reaction diagram
-
-
-
-
?
2-quinolinone-4-carboxaldehyde + NAD+ + H2O
2-quinolinone-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
3,4-dihydroxyphenylacetaldehyde + NAD+ + H2O
3,4-dihydroxyphenylacetate + NADH + H+
show the reaction diagram
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O
3,4-dihydroxyphenylglycolate + NADH + H+
show the reaction diagram
-
-
-
?
3,4-dimethoxybenzaldehyde + NAD+ + H2O
3,4-dimethoxybenzoate + NADH
show the reaction diagram
-
-
-
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?
3-pyridinecarboxaldehyde + NAD+ + H2O
3-pyridinecarboxylate + NADH
show the reaction diagram
-
-
-
-
?
4-aminobutyraldehyde + NAD+ + H2O
4-aminobutyrate + NADH
show the reaction diagram
-
-
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?
4-dimethylamino-1-naphthaldehyde + NAD+ + H2O
4-dimethylamino-1-naphthoic acid + NADH + H+
show the reaction diagram
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?
4-dimethylaminobenzaldehyde + NAD+ + H2O
4-dimethylaminobenzoate + NADH + H+
show the reaction diagram
-
-
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?
4-formylpyrene + NAD+
pyrene 4-carboxylate + NADH + H+
show the reaction diagram
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?
4-formylpyrene + NAD+ + H2O
pyrene-4-carboxylic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
4-hydroxy-2-nonenal + NAD+ + H2O
4-hydroxy-2-nonenoate + NADH + H+
show the reaction diagram
-
low affinity for substrate binding and poor catalytic efficiency
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?
4-hydroxy-3-methoxybenzaldehyde + NAD+ + H2O
4-hydroxy-3-methoxybenzoate + NADH + H+
show the reaction diagram
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-
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?
4-hydroxynon-2-enal + NAD+
4-hydroxynon-2-enoic acid + NADH
show the reaction diagram
-
-
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?
4-hydroxynonenal + NAD+ + H2O
4-hydroxynonaoate + NADH
show the reaction diagram
-
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?
4-methoxy-1-naphthaldehyde + NAD+ + H2O
4-methoxy-1-naphthoate + NADH
show the reaction diagram
-
-
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?
4-methoxy-1-naphthaldehyde + NAD+ + H2O
4-methoxy-1-naphthoic acid + NADH + H+
show the reaction diagram
-
-
-
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?
4-methoxybenzaldehyde + NAD+ + H2O
4-methoxybenzoate + NADH + H+
show the reaction diagram
-
-
-
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?
4-nitro-1-naphthaldehyde + NAD+ + H2O
4-nitro-1-naphthoate + NADH
show the reaction diagram
-
-
-
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?
4-oxonon-2-enal + NAD+ + H2O
4-oxonon-2-enoic acid + NADH
show the reaction diagram
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?
5-bromo-1-naphthaldehyde + NAD+ + H2O
5-bromo-1-naphthoate + NADH
show the reaction diagram
-
-
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?
5-methoxyindole-3-carboxaldehyde + NAD+ + H2O
5-methoxyindole-3-carboxylate + NADH
show the reaction diagram
-
-
-
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?
6,7-dimethoxycoumarin-4-carboxaldehyde + NAD+ + H2O
6,7-dimethoxycoumarin-4-carboxylate + NADH
show the reaction diagram
-
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-
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?
6-(dimethylamino)-2-naphthaldehyde + NAD+ + H2O
6-(dimethylamino)-2-naphthoate + NADH
show the reaction diagram
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?
6-dimethylamino-2-naphthaldehyde + NAD+ + H2O
6-dimethylamino-2-naphthalene carboxylate + NADH + H+
show the reaction diagram
-
activity assay
-
-
?
6-dimethylamino-2-naphthaldehyde + NAD+ + H2O
6-dimethylamino-2-naphthoic acid + NADH + H+
show the reaction diagram
-
-
-
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?
6-methoxy-2-naphthaldehyde + NAD+ + H2O
6-methoxy-2-naphthalene carboxylate + NADH + H+
show the reaction diagram
-
activity assay
-
-
?
6-methoxy-2-naphthaldehyde + NAD+ + H2O
6-methoxy-2-naphthoate + NADH + H+
show the reaction diagram
6-methoxy-2-naphthaldehyde + NAD+ + H2O
6-methoxy-2-naphthoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
6-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O
6-methoxy-2-quinolinone-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
7-(dimethylamino)-2-quinolinone-4-carboxaldehyde + NAD+ + H2O
7-(dimethylamino)-2-quinolinone-4-carboxylate + NADH
show the reaction diagram
-
-
-
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?
7-(dimethylamino)coumarin-4-carboxaldehyde + NAD+ + H2O
7-(dimethylamino)coumarin-4-carboxylate + NADH
show the reaction diagram
-
-
-
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?
7-acetoxycoumarin-4-carboxaldehyde + NAD+ + H2O
7-acetoxycoumarin-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
7-hydroxycoumarin-4-carboxaldehyde + NAD+ + H2O
7-hydroxycoumarin-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
7-methoxy-1-naphthaldehyde + NAD+ + H2O
7-methoxy-1-naphthoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
7-methoxy-2-quinolinone-4-carboxaldehyde + NAD+ + H2O
7-methoxy-2-quinolinone-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
7-methoxycoumarin-4-carboxaldehyde + NAD+ + H2O
7-methoxycoumarin-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
9-cis retinal + NAD+ + H2O
9-cis retinoic acid + NADH
show the reaction diagram
-
-
-
-
?
9-cis-retinal + NAD+ + H2O
9-cis-retinoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
acrolein + NAD+ + H2O
? + NADH + H+
show the reaction diagram
-
-
-
-
?
aldophosphamide + NAD+ + H2O
? + NADH + H+
show the reaction diagram
-
-
-
-
?
all-trans retinal + NAD+ + H2O
all-trans retinoic acid + NADH
show the reaction diagram
-
-
-
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?
all-trans-retinal + NAD+ + H2O
all-trans-retinoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
alpha-aminoadipate semialdehyde + NAD+ + H2O
alpha-aminoadipate + NADH + H+
show the reaction diagram
alpha-aminoadipate semialdehyde + NAD+ + H2O
alpha-aminoadipic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
alpha-phenylpropanal + NAD+ + H2O
alpha-phenylpropionate + NADH
show the reaction diagram
-
-
-
-
?
an aldehyde + NAD+ + H2O
an acid + NADH + H+
show the reaction diagram
-
-
-
-
?
benzaldehyde + NAD+ + H2O
benzoate + NADH + H+
show the reaction diagram
betaine aldehyde + NAD+ + H2O
betaine + NADH
show the reaction diagram
-
-
-
-
?
betaine aldehyde + NAD+ + H2O
betaine + NADH + H+
show the reaction diagram
-
-
-
-
?
chloroacetaldehyde + NAD+ + H2O
chloroacetate + NADH + H+
show the reaction diagram
cinnamic aldehyde + NAD+ + H2O
cinnamic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
dansyl-aminoacetaldehyde + ?
dansylglycine + ?
show the reaction diagram
-
the fluorescent substrate is used to monitor aldehyde dehydrogenase activity in fluorescence-activated cell sorting
-
-
?
decanal + NAD+ + H2O
decanoate + NADH
show the reaction diagram
-
-
-
-
?
fluorene-2-carboxaldehyde + NAD+ + H2O
fluorene-2-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
formaldehyde + NAD+
formate + NADH + H+
show the reaction diagram
-
-
-
-
?
formaldehyde + NAD+ + H2O
formate + NADH
show the reaction diagram
-
activity with enzyme ALDH-2, no activity with enzyme ALDH-1
-
-
?
formaldehyde + NAD+ + H2O
formate + NADH + H+
show the reaction diagram
-
-
-
-
?
glutathione-4-oxonon-2-enal + NAD+ + H2O
glutathione-4-oxonon-2-enoic acid + NADH
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NAD+ + H2O
glycerate + NADH
show the reaction diagram
-
-
-
-
?
glyceraldehyde + NAD+ + H2O
glycerate + NADH + H+
show the reaction diagram
-
-
-
-
?
glyceryl trinitrate + NADH + H+
1,2-glyceryl dinitrate + nitrite + NAD+
show the reaction diagram
-
-
-
-
?
glyceryl trinitrate + NADH + H+
1,3-glyceryl dinitrate + nitrite + NAD+
show the reaction diagram
-
-
-
-
?
glycolaldehyde + NAD+ + H2O
glycolate + NADH
show the reaction diagram
heptanal + NAD+ + H2O
heptanoate + NADH
show the reaction diagram
-
-
-
-
?
hexanal + NAD+ + H2O
hexanoate + NADH + H+
show the reaction diagram
hydrocinnamaldehyde + NAD+ + H2O
hydrocinnamate + NADH
show the reaction diagram
-
-
-
-
?
indole-3-acetaldehyde + NAD+ + H2O
indole-3-acetate + NADH + H+
show the reaction diagram
-
-
-
-
?
indole-3-aldehyde + NAD+ + H2O
indole-3-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
m-hydroxybenzaldehyde + NAD+ + H2O
m-hydroxybenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
m-methoxybenzaldehyde + NAD+ + H2O
m-methoxybenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
m-methylbenzaldehyde + NAD+ + H2O
m-methylbenzoate + NADH
show the reaction diagram
-
-
-
-
?
malondialdehyde + NAD+ + H2O
?
show the reaction diagram
-
low affinity for substrate binding and poor catalytic efficiency
-
-
?
malondialdehyde + NAD+ + H2O
? + NADH
show the reaction diagram
-
-
-
-
?
malondialdehyde + NAD+ + H2O
? + NADH + H+
show the reaction diagram
-
-
-
-
?
methylglyoxal + NAD+ + H2O
methylglyoxalate + NADH
show the reaction diagram
-
-
-
-
?
N-acetyl-4-aminobutyraldehyde + NAD+ + H2O
N-acetyl-4-aminobutyrate + NADH
show the reaction diagram
-
-
-
-
?
n-nonanal + NAD+ + H2O
n-nonanoate + NADH + H+
show the reaction diagram
nitroglycerin + NAD+ + H2O
1,2-glyceryl dinitrate + NO + NADH + H+
show the reaction diagram
-
-
-
-
?
o-hydroxybenzaldehyde + NAD+ + H2O
o-hydroxybenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
o-methoxybenzaldehyde + NAD+ + H2O
o-methoxybenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
o-methylbenzaldehyde + NAD+ + H2O
o-methylbenzoate + NADH
show the reaction diagram
-
-
-
-
?
o-nitrobenzaldehyde + NAD+ + H2O
o-nitrobenzoate + NADH
show the reaction diagram
-
-
-
-
?
octanal + NAD+ + H2O
octanoate + NADH
show the reaction diagram
-
-
-
-
?
octanal + NAD+ + H2O
octanoate + NADH + H+
show the reaction diagram
-
high specificity
-
-
?
p-(dimethylamino)-benzaldehyde + NAD+ + H2O
p-(dimethylamino)benzoate + NADH
show the reaction diagram
-
-
-
-
?
p-(dimethylamino)cinnamaldehyde + NAD+ + H2O
p-(dimethylamino)cinnamate + NADH
show the reaction diagram
-
-
-
-
?
p-methoxybenzaldehyde + NAD+ + H2O
p-methoxybenzoate + NADH + H+
show the reaction diagram
-
-
-
-
?
p-methylbenzaldehyde + NAD+ + H2O
p-methylbenzoate + NADH
show the reaction diagram
-
-
-
-
?
p-nitrobenzaldehyde + NAD+ + H2O
p-nitrobenzoate + NADH
show the reaction diagram
-
-
-
-
?
p-nitrocinnamaldehyde + NAD+ + H2O
p-nitrocinnamate + NADH
show the reaction diagram
-
-
-
-
?
pentanal + NAD+ + H2O
pentanoate + NADH
show the reaction diagram
-
-
-
-
?
phenanthrene-9-carboxaldehyde + NAD+ + H2O
phenanthrene-9-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
phenylacetaldehyde + NAD+ + H2O
phenylacetate + NADH + H+
show the reaction diagram
-
-
-
-
?
propanal + 1,N6-ethenoadenine dinucleotide + H2O
propionate + ?
show the reaction diagram
-
isoenzyme E3
-
-
?
propanal + 3-acetylpyridine-adenine dinucleotide + H2O
propionate + ?
show the reaction diagram
-
isoenzyme E3
-
-
?
propanal + 3-thionicotinamide-adenine dinucleotide + H2O
propionate + ?
show the reaction diagram
-
isoenzyme E3
-
-
?
propanal + N-guanine dinucleotide + H2O
propionate + ?
show the reaction diagram
-
isoenzyme E3
-
-
?
propanal + NAD+ + H2O
propanoate + NADH + H+
show the reaction diagram
-
-
-
-
?
propanal + NAD+ + H2O
propanoic acid + NADH + H+
show the reaction diagram
-
activity assay
-
-
?
propanal + NAD+ + H2O
propionate + NADH
show the reaction diagram
propanal + NAD+ + H2O
propionate + NADH + H+
show the reaction diagram
-
-
-
-
?
propanal + oxidized nicotinamide hypoxanthine dinucleotide + H2O
propionate + reduced nicotinamide hypoxanthine dinucleotide
show the reaction diagram
-
isoenzyme E3
-
-
?
propionaldehyde + NAD+
propionate + NADH + H+
show the reaction diagram
-
-
-
-
?
propionaldehyde + NAD+ + H2O
propionate + NADH
show the reaction diagram
-
-
-
-
?
propionaldehyde + NAD+ + H2O
propionate + NADH + H+
show the reaction diagram
-
-
-
-
?
quinoline-3-carboxaldehyde + NAD+ + H2O
quinoline-3-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
quinoline-4-carboxaldehyde + NAD+ + H2O
quinoline-4-carboxylate + NADH
show the reaction diagram
-
-
-
-
?
retinal + NAD+ + H2O
retinoic acid + NADH + H+
show the reaction diagram
-
-
-
?
trans-cinnamaldehyde + NAD+ + H2O
trans-cinnamate + NADH
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetaldehyde + NAD+ + H2O
acetate + NADH + H+
show the reaction diagram
-
-
-
-
?
all-trans-retinal + NAD+ + H2O
all-trans-retinoic acid + NADH + H+
show the reaction diagram
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alpha-aminoadipate semialdehyde + NAD+ + H2O
alpha-aminoadipate + NADH + H+
show the reaction diagram
an aldehyde + NAD+ + H2O
an acid + NADH + H+
show the reaction diagram
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additional information
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADP+
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additional information
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very low activity
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(4-chlorophenyl)-3-(1-piperidinyl)-1-propanone
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1-ethoxycyclopropanol
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2,4-dinitrobenzaldehyde
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substrate inhibition
2,6-Dichloro-4-nitrophenol
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primarily inhibits isoform ALDH2 (non-competitive), but does not affect isoform ALDH3A1
2-naphthaldehyde
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substrate inhibition
3-(1-azepanyl)-1-phenyl-1-propanone
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3-(dimethylamino)-1-(3-fluoro-4-methoxyphenyl)-1-propanone
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3-(dimethylamino)-1-(4-ethylphenyl)-1-propanone
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4-diethylaminobenzaldehyde
4-hydroxy-2-nonenal
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4-hydroxy-2-nonenal completely inactivates ALDH2 activity in vitro at 100 mM
4-hydroxynon-2-enal
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10% inhibition at 0.05 mM
4-oxonon-2-enal
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90% inhibition at 0.05 mM
4-oxonon-2-enoic acid
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90% inhibition at 0.05 mM
6-[O-(CH2)5-COOH]-2-naphthaldehyde
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substrate inhibition
acetaldehyde
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0.02 mM, substrate inhibition of isoenzyme I, no inhibition of isoenzyme II and III
acrolein
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adenine
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adenosine
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adenosine 5'-monophosphate
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competitive with NAD+ and noncompetitive with acetaldehyde
Alda-1
arsenite
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47% residual activity at 1 mM arsenite at pH 9.5, 28% residual activity at 2 mM arsenite at pH 7.4
Caffeine
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Chloral hydrate
Chloroacetaldehyde
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86% residual activity at 1 mM chloroacetaldehyde at pH 9.5
cyanamide
daidzin
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diethylaminobenzaldehyde
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0.025 mM diethylaminobenzaldehyde inhibits about 80% of the enzymatic activity
dimethyl ampal thiolester
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78% inhibition of isozyme ALDH1 at 0.0075 mM
Disulfiram
glyceraldehyde
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substrate inhibition
m-methylbenzaldehyde
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substrate inhibition
methyl ampal thiolester
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32% inhibition of isozyme ALDH1 at 0.0075 mM
methylglyoxal
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substrate inhibition
molinate
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irreversible inhibition of ALDH2
molinate sulfoxide
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i.e. S-ethyl-hexahydro-1H-azepine-1-carbothioate sulfoxide, irreversible inhibition of ALDH2
N'-methylnicotinamide
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NAD+
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pronounced inhibition occurs at above 5 mM
nitroglycerin
o-nitrobenzaldehyde
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substrate inhibition
p-methylbenzaldehyde
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substrate inhibition
p-nitrobenzaldehyde
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substrate inhibition
p-nitrocinnamaldehyde
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substrate inhibition
theophylline
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thio-NAD+
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additional information
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
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highest activity at 50 mM
Alda-1