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Information on EC 1.17.8.1 - hydroxysqualene dehydroxylase

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EC Tree
     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.8 With a flavin as acceptor
                1.17.8.1 hydroxysqualene dehydroxylase
IUBMB Comments
This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
hpnE, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
squalene + FAD + H2O = hydroxysqualene + FADH2
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PATHWAY SOURCE
PATHWAYS
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