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Information on EC 1.17.3.4 - juglone 3-hydroxylase

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EC Tree
     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.3 With oxygen as acceptor
                1.17.3.4 juglone 3-hydroxylase
IUBMB Comments
Even though oxygen is consumed, molecular oxygen is not incorporated into the product. Catalysis starts by incorporation of an oxygen atom from a water molecule into the substrate. The naphthalene-1,2,4,8-tetrol intermediate is then oxidized by molecular oxygen, which is reduced to water. Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-1,4-naphthoquinone.
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The expected taxonomic range for this enzyme is: Pseudomonas putida
Reaction Schemes
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Synonyms
juglone 3-monooxygenase, juglone hydroxylase, naphthoquinone hydroxylase, naphthoquinone-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 juglone + 2 H2O = 2 naphthalene-1,2,4,8-tetrol
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(1a)
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2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone
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overall reaction
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2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H2O
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(1b)
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PATHWAY SOURCE
PATHWAYS
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