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Information on EC 1.17.3.3 - 6-hydroxynicotinate dehydrogenase

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EC Tree
     1 Oxidoreductases
         1.17 Acting on CH or CH2 groups
             1.17.3 With oxygen as acceptor
                1.17.3.3 6-hydroxynicotinate dehydrogenase
IUBMB Comments
Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.
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The enzyme appears in viruses and cellular organisms
Synonyms
6-HDH, 6-hydroxynicotinate hydroxylase, 6-hydroxynicotinic acid dehydrogenase, 6-hydroxynicotinic acid hydroxylase, dehydrogenase, 6-hydroxynicotinate, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2
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