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dehydrogenase, formate
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EC 1.2.1.2
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formerly
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formate benzyl-viologen oxidoreductase
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formate dehydrogenase
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formate dehydrogenase (NAD)
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formate-NAD oxidoreductase
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formate:NAD oxidoreductase
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formic acid dehydrogenase
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molybdenum-containing formate dehydrogenase H
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NAD(P)+.dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
NAD-dependent formate dehydrogenase
NAD-formate dehydrogenase
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NAD-linked formate dehydrogenase
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NAD-specific formate dehydrogenase
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tungsten-containing formate dehydrogenase
FDB2
isozyme
FDH
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FDH
Thermochaetoides thermophila
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FDH
Thermochaetoides thermophila DSM 1495
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FDH
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686449, 687304, 699307, 700012, 711548, 711549, 713421, 724766, 725739, 726088, 740947, 742266, 743143, 743726
FDH I
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Fdh-H
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FDH1
isozyme
Fdh2
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Fdh3
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FDHH
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FdsABG
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FoDH1
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formate dehydrogenase H
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formate dehydrogenase H
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MycFDH
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
Thermochaetoides thermophila
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NAD+-dependent formate dehydrogenase
Thermochaetoides thermophila DSM 1495
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
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NAD+-dependent formate dehydrogenase
Q00498
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NAD-dependent FDH
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-dependent formate dehydrogenase
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NAD-FDH
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tungsten-containing formate dehydrogenase
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tungsten-containing formate dehydrogenase
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formate + NAD+ = CO2 + NADH + H+
formate + NAD+ = CO2 + NADH + H+
sequential mechanism
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formate + NAD+ = CO2 + NADH + H+
ordered mechanism
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formate + NAD+ = CO2 + NADH + H+
sequential ordered bi-bi mechanism
Candida methanolica
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formate + NAD+ = CO2 + NADH + H+
ordered kinetic mechanism with NAD+ adding before formate
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formate + NAD+ = CO2 + NADH + H+
ordered bi-bi mechanism, NAD+ is the first substrate and NADH is the last product
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formate + NAD+ = CO2 + NADH + H+
hydride-transfer step is rate-limiting
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formate + NAD+ = CO2 + NADH + H+
ordered BiBi mechanism with NAD+ and NADH being the first substrate and the second product, resp.
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formate + NAD+ = CO2 + NADH + H+
reaction mechanism: step I, formate binds directly to Mo, displacing Se-Cys140. Step II, the alpha-proton from formate may be transferred to the nearby His141 that acts as general base. Alternatively, step II may involve a selenium-carboxylated intermediate. Step III, electrons from MoIV are transferred via the 4Fe-4S center to an external electron acceptor and the catalytic cycle is completed
formate + NAD+ = CO2 + NADH + H+
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2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
4-(formyloxy)butyl acetate + NAD+
?
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59% conversion
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?
butyl formate + NAD+
?
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41% conversion
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?
CO2 + NADH
formate + NAD+
CO2 + reduced 1,1'-diaminoethyl-4,4'-bipyridinium salt
formate + 1,1'-diaminoethyl-4,4'-bipyridinium salt
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?
CO2 + reduced 1,1'-dicarboxyl-4,4'-bipyridinium salt
formate + 1,1'-dicarboxyl-4,4'-bipyridinium salt
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?
CO2 + reduced 1,1'-diphenyl-4,4'-bipyridinium salt
formate + 1,1'-diphenyl-4,4'-bipyridinium salt
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?
CO2 + reduced 1-methyl-1'-aminoethyl-4,4'-bipyridinium salt
formate + 1-methyl-1'-aminoethyl-4,4'-bipyridinium salt
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?
CO2 + reduced 1-methyl-1'-carboxymethyl-4,4'-bipyridinium salt
formate + 1-methyl-1'-carboxymethyl-4,4'-bipyridinium salt
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?
CO2 + reduced methyl viologen
formate + methyl viologen
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?
formate + 2,6-dichloroindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
formate + 2,6-dichlorophenolindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
formate + 3-acetylpyridine-NAD+
CO2 + 3-acetylpyridine-NADH
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r
formate + 3-pyridinecarboxaldehyde-NAD+
CO2 + 3-pyridinecarboxaldehyde-NADH
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
formate + benzyl viologen
CO2 + reduced benzyl viologen + H+
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?
formate + cytochrome c
CO2 + reduced cytochrome c
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?
formate + deamino-NAD+
CO2 + deamino-NADH
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r
formate + dextran-NAD+
CO2 + dextran-NADH
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enzyme immobilized on glyoxyl agarose, 60% of the activity with NAD+
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?
formate + FAD
CO2 + FADH2
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?
formate + ferricyanide
CO2 + ferrocyanide
formate + FMN
CO2 + FMNH2
formate + methyl viologen
CO2 + reduced methyl viologen
formate + methylene blue
CO2 + reduced methylene blue
formate + NAD+
CO2 + NADH + H+
formate + NAD+ + OH-
HCO3- + NADH + H+
formate + NADP+
CO2 + NADPH
formate + NADP+
CO2 + NADPH + H+
formate + NADP+
CO2 + NAPDH
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NADP+ is a substrate for mutant enzymes only
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?
formate + nitrobluetetrazolium
CO2 + reduced nitrobluetetrazolium
formate + O2
CO2 + H2O2
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?
formate + phenazine methosulfate
CO2 + reduced phenazine methosulfate
formate + riboflavin
CO2 + reduced riboflavin
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?
formate + thio-NAD+
CO2 + thio-NADH
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r
glyoxylate + NAD+
? + NADH
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wild-type, low activity towards glyoxylate
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?
HCO3- + NADH
formate + NAD+
methyl formate + NAD+
?
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23% conversion
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?
NADH + 2,6-dichloroindophenol
NAD+ + reduced 2,6-dichlorophenolindophenol
NADH + benzyl viologen
NAD+ + reduced benzyl viologen
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?
phenyl formate + NAD+
?
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86% conversion
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?
propyl formate + NAD+
?
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39% conversion
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?
S-formylglutathione + NAD+
?
S-formylthioglycolate + NAD+
?
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?
additional information
?
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2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
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?
2 ferricyanide + NADH
2 ferrocyanide + NAD+ + H+
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?
CO2 + NADH
formate + NAD+
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r
CO2 + NADH
formate + NAD+
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r
CO2 + NADH
formate + NAD+
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r
CO2 + NADH
formate + NAD+
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r
CO2 + NADH
formate + NAD+
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?
CO2 + NADH
formate + NAD+
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?
CO2 + NADH
formate + NAD+
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r
CO2 + NADH
formate + NAD+
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r
CO2 + NADH
formate + NAD+
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the enzyme exhibits a dramatic preference for the CO2 reduction reaction over the oxidation reaction of formate
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r
CO2 + NADH
formate + NAD+
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the enzyme exhibits a dramatic preference for the CO2 reduction reaction over the oxidation reaction of formate
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r
CO2 + NADH
formate + NAD+
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?
ethyl formate + NAD+
?
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?
ethyl formate + NAD+
?
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26% conversion
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?
formate + 2,6-dichloroindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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54% of the activity with NAD+
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?
formate + 2,6-dichloroindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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?
formate + 2,6-dichloroindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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33% of the activity with NAD+
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?
formate + 2,6-dichloroindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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?
formate + 2,6-dichlorophenolindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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r
formate + 2,6-dichlorophenolindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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?
formate + 2,6-dichlorophenolindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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?
formate + 2,6-dichlorophenolindophenol
CO2 + reduced 2,6-dichlorophenolindophenol
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
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113% of the activity with NAD+
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
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r
formate + benzyl viologen
CO2 + reduced benzyl viologen
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r
formate + benzyl viologen
CO2 + reduced benzyl viologen
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
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?
formate + benzyl viologen
CO2 + reduced benzyl viologen
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?
formate + ferricyanide
CO2 + ferrocyanide
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10% of the activity with NAD+
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?
formate + ferricyanide
CO2 + ferrocyanide
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?
formate + ferricyanide
CO2 + ferrocyanide
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?
formate + ferricyanide
CO2 + ferrocyanide
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?
formate + FMN
CO2 + FMNH2
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?
formate + FMN
CO2 + FMNH2
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?
formate + methyl viologen
CO2 + reduced methyl viologen
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74% of the activity with NAD+
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?
formate + methyl viologen
CO2 + reduced methyl viologen
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?
formate + methyl viologen
CO2 + reduced methyl viologen
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r
formate + methylene blue
CO2 + reduced methylene blue
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119% of the activity with NAD+
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?
formate + methylene blue
CO2 + reduced methylene blue
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?
formate + NAD+
CO2 + NADH + H+
Achromobacter parvulus
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
Arabidopsis thaliana cv. Xanthi
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
the enzyme shows strict substrate specificity for formate
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?
formate + NAD+
CO2 + NADH + H+
the enzyme shows strict substrate specificity for formate
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?
formate + NAD+
CO2 + NADH + H+
Candida methanolica
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?
formate + NAD+
CO2 + NADH + H+
Candida methanolica
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one of the key enzymes in the assimilation of C1 compounds, such as methanol
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
-
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
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?
formate + NAD+
CO2 + NADH + H+
-
-
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?
formate + NAD+
CO2 + NADH + H+
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r
formate + NAD+
CO2 + NADH + H+
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equilibrium strongly favors dehydrogenation of formate
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r
formate + NAD+
CO2 + NADH + H+
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enzyme catalyzes formate oxidation about 30times faster than the CO2 reduction
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r
formate + NAD+
CO2 + NADH + H+
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enzyme provides NADH for synthesis
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?
formate + NAD+
CO2 + NADH + H+
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when Pseudomonas oxalaticus is grown on formate as main carbon and energy source, formate dehydrogenase is the key enzyme that generates NADH and CO
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?
formate + NAD+
CO2 + NADH + H+
-
equilibrium strongly favors dehydrogenation of formate
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r
formate + NAD+
CO2 + NADH + H+
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r
formate + NAD+
CO2 + NADH + H+
-
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-
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?
formate + NAD+
CO2 + NADH + H+
-
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r
formate + NAD+
CO2 + NADH + H+
-
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-
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?
formate + NAD+
CO2 + NADH + H+
100% specificity
-
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?
formate + NAD+
CO2 + NADH + H+
100% specificity
-
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?
formate + NAD+
CO2 + NADH + H+
-
-
-
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?
formate + NAD+
CO2 + NADH + H+
-
-
-
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?
formate + NAD+
CO2 + NADH + H+
-
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ir
formate + NAD+
CO2 + NADH + H+
-
-
-
-
?
formate + NAD+
CO2 + NADH + H+
-
induced by methanol and formate
-
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?
formate + NAD+
CO2 + NADH + H+
-
-
-
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?
formate + NAD+
CO2 + NADH + H+
-
induced by methanol and formate
-
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?
formate + NAD+
CO2 + NADH + H+
Kloeckera sp.
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-
?
formate + NAD+
CO2 + NADH + H+
Kloeckera sp.
-
last step of methanol oxidation system
-
-
?
formate + NAD+
CO2 + NADH + H+
1.17.1.9 formate dehydrogenase
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