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Information on EC 1.17.1.9 - formate dehydrogenase

for references in articles please use BRENDA:EC1.17.1.9

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IUBMB Comments

The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre . Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
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formate
+
NAD+
=
CO2
+
NADH
+
H+
+
=
+
+

Synonyms
formate dehydrogenase, formate dehydrogenase h, fdh-h, nad-dependent formate dehydrogenase, fdh-n, nad+-dependent formate dehydrogenase, psefdh, fdh-o, fdsabg, mycfdh, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
formate + NAD+ = CO2 + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
formate oxidation to CO2, oxalate degradation III, oxalate degradation VI, purine nucleobases degradation I (anaerobic), purine nucleobases degradation II (anaerobic)