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Information on EC 1.16.99.1 - [Co(II) methylated amine-specific corrinoid protein] reductase

for references in articles please use BRENDA:EC1.16.99.1
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EC Tree
IUBMB Comments
Methyltrophic corrinoid proteins must have the cobalt atom in the active cobalt(I) state to become methylated. Because the cobalt(I)/cobalt(II) transformation has a very low redox potential the corrinoid cofactor is subject to adventitious oxidation to the cobalt(II) state, which renders the proteins inactive. This enzyme, characterized from the methanogenic archaeon Methanosarcina barkeri, reduces cobalt(II) back to cobalt(I), restoring activity. The enzyme acts on the corrinoid proteins involved in methanogenesis from methylamine, dimethylamine, and trimethylamine, namely MtmC, MtbC, and MttC, respectively. While in vitro the enzyme can use Ti(III)-citrate as the electron donor, the in vivo donor is not known. The enzyme from Methanosarcina barkeri contains a C-terminal [4Fe-4S] ferredoxin-like domain.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Reaction Schemes
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a [Co(II) methylamine-specific corrinoid protein]
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a [Co(I) methylamine-specific corrinoid protein]
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a [Co(II) dimethylamine-specific corrinoid protein]
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a [Co(I) dimethylamine-specific corrinoid protein]
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a [Co(II) trimethylamine-specific corrinoid protein]
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a [Co(I) trimethylamine-specific corrinoid protein]
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Synonyms
OdmC, RamA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + a [Co(II) methylamine-specific corrinoid protein] + reduced acceptor + H2O = ADP + phosphate + a [Co(I) methylamine-specific corrinoid protein] + acceptor
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ATP + a [Co(II) dimethylamine-specific corrinoid protein] + reduced acceptor + H2O = ADP + phosphate + a [Co(I) dimethylamine-specific corrinoid protein] + acceptor
show the reaction diagram
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ATP + a [Co(II) trimethylamine-specific corrinoid protein] + reduced acceptor + H2O = ADP + phosphate + a [Co(I) trimethylamine-specific corrinoid protein] + acceptor
show the reaction diagram
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