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Information on EC 1.16.3.2 - bacterial non-heme ferritin and Organism(s) Bacteroides fragilis and UniProt Accession E1WS50

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EC Tree
     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.3 With oxygen as acceptor
                1.16.3.2 bacterial non-heme ferritin
IUBMB Comments
Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. Thousands of mineralized iron atoms are stored within the core of the structure. The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction.
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Bacteroides fragilis
UNIPROT: E1WS50
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Word Map
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The taxonomic range for the selected organisms is: Bacteroides fragilis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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4
Fe(II)
+
O2
+
6
H2O
=
4
[FeO(OH)]
+
8
H+
4
+
+
6
=
4
+
8
Synonyms
ferritin a, dna-binding protein from starved cells, ecftna, cjdps, non-heme ferritin, non-heme type bacterial ferritin, bacterial non-heme ferritin, non-heme bacterial ferritin, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
non-heme ferritin
-
HuHF
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Fe(II):oxygen oxidoreductase ([FeO(OH)]core-producing)
Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. Thousands of mineralized iron atoms are stored within the core of the structure. The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Fe(II) + O2 + H2O
[FeO(OH)] + H+ + H2O2
show the reaction diagram
-
-
-
?
Fe(II) + O2 + H2O
[FeO(OH)] + H+ + H2O2
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Fe(II) + O2 + H2O
[FeO(OH)] + H+ + H2O2
show the reaction diagram
-
-
-
?
Fe(II) + O2 + H2O
[FeO(OH)] + H+ + H2O2
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in the presence of diamide and potassium ferrycianide, enzyme expression is upregulated 5-12fold
in the presence of diamide and potassium ferrycianide, enzyme expression is upregulated 5-12fold
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rocha, E.R.; Smith, C.J.
Ferritin-like family proteins in the anaerobe Bacteroides fragilis: when an oxygen storm is coming, take your iron to the shelter
Biometals
26
577-591
2013
Bacteroides fragilis (E1WS50), Bacteroides fragilis (P0CJ83), Bacteroides fragilis (Q5LBE2), Bacteroides fragilis, Bacteroides fragilis 638R (E1WS50), Bacteroides fragilis NCTC 9343 (Q5LBE2), Bacteroides fragilis YCH46 (P0CJ83)
Manually annotated by BRENDA team