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Information on EC 1.16.3.1 - ferroxidase

for references in articles please use BRENDA:EC1.16.3.1

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IUBMB Comments

The enzyme in blood plasma (ceruloplasmin) belongs to the family of multicopper oxidases. In humans it accounts for 95% of plasma copper. It oxidizes Fe(II) to Fe(III), which allows the subsequent incorporation of the latter into proteins such as apotransferrin and lactoferrin. An enzyme from iron oxidizing bacterium strain TI-1 contains heme a.

The enzyme appears in viruses and cellular organisms

Synonyms
ferritin, ceruloplasmin, ferroxidase, apoferritin, xanthine oxidoreductase, caeruloplasmin, l-ferritin, hephaestin, bacterioferritin, hp-nap, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS