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Information on EC 1.16.1.6 - cyanocobalamin reductase (cyanide-eliminating)

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IUBMB Comments
The mammalian enzyme, which is cytosolic, can bind internalized cyanocobalamin and process it to cob(II)alamin by removing the upper axial ligand. The product remains bound to the protein, which, together with its interacting partner MMADHC, transfers it directly to downstream enzymes involved in adenosylcobalamin and methylcobalamin biosynthesis. In addition to its decyanase function, the mammalian enzyme also catalyses an entirely different chemical reaction with alkylcobalamins, using the thiolate of glutathione for nucleophilic displacement, generating cob(I)alamin and the corresponding glutathione thioether (cf. EC 2.5.1.151, alkylcobalamin dealkylase).
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The enzyme appears in viruses and cellular organisms
Synonyms
cyanobalamin reductase (NADPH, cyanide-eliminating), cyanocobalamin reductase, cyanocobalamin reductase (NADPH, CN-eliminating), EC 1.6.99.12, NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating), more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 cob(II)alamin-[cyanocobalamin reductase] + 2 hydrogen cyanide + NADP+ = 2 cyanocob(III)alamin + 2 [cyanocobalamin reductase] + NADPH + H+
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A flavoprotein
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