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Information on EC 1.16.1.10 - ferric-chelate reductase [NAD(P)H] and Organism(s) Arabidopsis thaliana and UniProt Accession Q9FLW2

for references in articles please use BRENDA:EC1.16.1.10
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EC Tree
     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.10 ferric-chelate reductase [NAD(P)H]
IUBMB Comments
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9FLW2
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Word Map
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  • 1.16.1.10
  • epileptic
  • encephalopathy
  • hyperkinetic
  • choreoathetosis
  • excitatory
  • biallelic
  • neurodevelopmental
  • ampa-receptors
  • ampars
  • sleep
  • neurotransmission
  • glutamatergic
  • electrograph
  • synapses
  • dyskinesia
  • monogenic
  • electroencephalogram
  • co-assembled
  • pore-forming
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
hide
2
Fe(II)-siderophore
+
NAD(P)+
+
H+
=
2
Fe(III)-siderophore
+
NAD(P)H
2
Fe(II)-siderophore
+
+
=
2
Fe(III)-siderophore
+
Synonyms
frrs1l, af0830, fro protein, chloroplast ferric chelate oxidoreductase, ferric chelate reductase 1 like protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ferric chelate reductase
-
ferric chelate reductase
-
ferric-chelate reductase (NAD(P)H)
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Fe(II)-siderophore:NAD(P)+ oxidoreductase
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 Fe(II)-ferrozine + NAD(P)+ + H+
2 Fe(III)-ferrozine + NAD(P)H
show the reaction diagram
-
-
-
?
2 Fe(II)-siderophore + NAD(P)+ + H+
2 Fe(III)-siderophore + NAD(P)H
show the reaction diagram
-
-
-
?
2 Fe(II)-ferrozine + NAD(P)+ + H+
2 Fe(III)-ferrozine + NAD(P)H
show the reaction diagram
-
-
-
?
2 Fe(II)-siderophore + NAD(P)+ + H+
2 Fe(III)-siderophore + NAD(P)H
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 Fe(II)-siderophore + NAD(P)+ + H+
2 Fe(III)-siderophore + NAD(P)H
show the reaction diagram
-
-
-
?
2 Fe(II)-siderophore + NAD(P)+ + H+
2 Fe(III)-siderophore + NAD(P)H
show the reaction diagram
-
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
CIPK23
a protein kinase, required for enzyme activity because CIPK23 helps in iron aquisition. Involvement of calcium-dependent CBL-CIPK23 complexes in the regulation of iron acquisition
-
CIPK23
a protein kinase, required for enzyme activity because CIPK23 helps in iron aquisition. Involvement of calcium-dependent CBL-CIPK23 complexes in the regulation of iron acquisition
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity, leading to chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions, phenotype, overview
metabolism
the protein kinase CIPK23 is involved in iron acquisition. Lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by downregulating ferric chelate reductase activity. Iron deficiency evokes an increase in cytosolic Ca2+ concentration, and the elevated Ca2+ binds to CBL1/CBL9, leading to activation of CIPK23, CBL-CIPK23complexes might be as nutritional sensors to sense and regulate the mineral homeostasis in Arabisopsis thaliana. Regulation of FCR activity by CIPK23 may not be achieved by modulation of genes FRO2, FRO3 and FRO5 at transcriptional level
physiological function
FCR activity in plants not only depends on FRO expression, abundance of FRO proteins, and but also depends on the levels of heme, ATP and NADPH/NADH
malfunction
lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity, leading to chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions, phenotype, overview
metabolism
the protein kinase CIPK23 is involved in iron acquisition. Lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by downregulating ferric chelate reductase activity. Iron deficiency evokes an increase in cytosolic Ca2+ concentration, and the elevated Ca2+ binds to CBL1/CBL9, leading to activation of CIPK23, CBL-CIPK23complexes might be as nutritional sensors to sense and regulate the mineral homeostasis in Arabisopsis thaliana. Regulation of FCR activity by CIPK23 may not be achieved by modulation of genes FRO2, FRO3 and FRO5 at transcriptional level
physiological function
FCR activity in plants not only depends on FRO expression, abundance of FRO proteins, and but also depends on the levels of heme, ATP and NADPH/NADH
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FRO5_ARATH
707
10
81166
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene FRO5, quantitative real-time PCR isozyme expression analysis
gene FRO2, quantitative real-time PCR isozyme expression analysis
gene FRO3, quantitative real-time PCR isozyme expression analysis
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity
lesion of CIPK23 renders Arabidopsis mutants hypersensitive to iron deficiency by downregulating ferric chelate reductase activity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tian, Q.; Zhang, X.; Yang, A.; Wang, T.; Zhang, W.H.
CIPK23 is involved in iron acquisition of Arabidopsis by affecting ferric chelate reductase activity
Plant Sci.
46
70-79
2016
Arabidopsis thaliana (F4I4K7), Arabidopsis thaliana (P92949), Arabidopsis thaliana (Q9FLW2), Arabidopsis thaliana Col-0 (F4I4K7), Arabidopsis thaliana Col-0 (P92949), Arabidopsis thaliana Col-0 (Q9FLW2)
Manually annotated by BRENDA team