Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.16.1.10 - ferric-chelate reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.16.1.10
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     1 Oxidoreductases
         1.16 Oxidizing metal ions
             1.16.1 With NAD+ or NADP+ as acceptor
                1.16.1.10 ferric-chelate reductase [NAD(P)H]
IUBMB Comments
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
UNIPROT: B1AXV0
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
  • 1.16.1.10
  • epileptic
  • encephalopathy
  • hyperkinetic
  • choreoathetosis
  • excitatory
  • biallelic
  • neurodevelopmental
  • ampa-receptors
  • ampars
  • sleep
  • neurotransmission
  • glutamatergic
  • electrograph
  • synapses
  • dyskinesia
  • monogenic
  • electroencephalogram
  • co-assembled
  • pore-forming
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
2
Fe(II)-siderophore
+
+
=
2
Fe(III)-siderophore
+
Synonyms
frrs1l, fro protein, chloroplast ferric chelate oxidoreductase, ferric chelate reductase 1 like protein, af0830, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ferric chelate reductase 1 like protein
-
ferric-chelate reductase (NAD(P)H)
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Fe(II)-siderophore:NAD(P)+ oxidoreductase
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
FRRS1L is a component of native AMPAR complexes in the brain
Manually annotated by BRENDA team
native FRRS1L in hippocampus is localized at dynein, but not kinesin5B, vesicles
Manually annotated by BRENDA team
hippocampal primary neuron cultures
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
ferric chelate reductase 1 like protein (FRRS1L) mutations in human lead to epilepsy, choreoathetosis, and cognitive deficits. Overexpression of enzyme FRRS1L in hippocampal neurons does not change glutamatergic synaptic transmission, but single-cell knockout of FRRS1L strongly reduces the surface and total expression levels of GluA1 in cultured hippocampal neurons, and significantly decreases AMPAR-mediated synaptic transmission in mouse hippocampal pyramidal neurons
physiological function
recombinant FRRS1L interacts with both GluA1 and GluA2 subunits of AMPA receptors, AMPARs, but does not form dimers/oligomers, in HEK293 cells. Important role of FRRS1L in the regulation of excitatory synaptic strength. FRRS1L is a component of native AMPAR complexes in the brain
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FRS1L_MOUSE
293
0
32507
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant expression in HEK293 cell plasma membrane
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Han, W.; Wang, H.; Li, J.; Zhang, S.; Lu, W.
Ferric chelate reductase 1 like protein (FRRS1L) associates with dynein vesicles and regulates glutamatergic synaptic transmission
Front. Mol. Neurosci.
10
402
2017
Mus musculus (B1AXV0), Mus musculus, Mus musculus C57B6 (B1AXV0)
Manually annotated by BRENDA team