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Disease on EC 1.14.99.66 - [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4.
Alzheimer Disease
The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
Breast Neoplasms
Functional characterization of lysine-specific demethylase 2 (LSD2/KDM1B) in breast cancer progression.
Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade.
Inhibitors of histone demethylation and histone deacetylation cooperate in regulating gene expression and inhibiting growth in human breast cancer cells.
LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition.
The histone demethylase LSD1 is required for estrogen-dependent S100A7 gene expression in human breast cancer cells.
Carcinogenesis
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
LSD1/KDM1A inhibitors in clinical trials: advances and prospects.
Significant association between KDM1A promoter hypomethylation and colorectal cancer in Han Chinese.
Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1.
Carcinoma
Genome-wide ChIP-seq data with a transcriptome analysis reveals the groups of genes regulated by histone demethylase LSD1 inhibition in esophageal squamous cell carcinoma cells.
H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1.
Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells.
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells.
Raloxifene, identified as a novel LSD1 inhibitor, suppresses the migration of renal cell carcinoma.
Carcinoma, Hepatocellular
Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma.
H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1.
Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.
Carcinoma, Renal Cell
Raloxifene, identified as a novel LSD1 inhibitor, suppresses the migration of renal cell carcinoma.
Cardiomyopathies
Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy.
Chickenpox
Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components.
Colorectal Neoplasms
Lysine-specific histone demethylase 1B (LSD2/KDM1B) represses p53 expression to promote proliferation and inhibit apoptosis in colorectal cancer through LSD2-mediated H3K4me2 demethylation.
Esophageal Squamous Cell Carcinoma
Genome-wide ChIP-seq data with a transcriptome analysis reveals the groups of genes regulated by histone demethylase LSD1 inhibition in esophageal squamous cell carcinoma cells.
Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells.
Glioblastoma
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1?-dependent pathway.
Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.
Glioma
Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.
Glomerulonephritis
The histone demethylase LSD1 promotes renal inflammation by mediating TLR4 signaling in hepatitis B virus-associated glomerulonephritis.
Hepatitis B
The histone demethylase LSD1 promotes renal inflammation by mediating TLR4 signaling in hepatitis B virus-associated glomerulonephritis.
Herpes Simplex
A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.
Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components.
Herpes Zoster
Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components.
Hyperglycemia
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Hypertension
Histone Demethylase LSD1 Deficiency during High Salt Diet is Associated with Enhanced Vascular Contraction, Altered NO-cGMP Relaxation Pathway, and Hypertension.
Infertility
A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory.
Influenza, Human
Correction: Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Intellectual Disability
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Kidney Neoplasms
Histone Demethylase LSD1 Regulates Kidney Cancer Progression by Modulating Androgen Receptor Activity.
The Histone Lysine-specific Demethylase 1 Inhibitor, SP2509 Exerts Cytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 and Mcl-1.
Laminopathies
Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy.
Leukemia
Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies.
LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B.
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Leukemia, Myeloid, Acute
Clinical Responsiveness to All-trans Retinoic Acid Is Potentiated by LSD1 Inhibition and Associated with a Quiescent Transcriptome in Myeloid Malignancies.
First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia.
Lymphoma, B-Cell
Target prioritization of novel substituted 5-aryl-2-oxo-/thioxo-2,3-dihydro-1H-benzo[6,7]chromeno[2,3-d]pyrimidine-4,6,11(5H)-triones as anticancer agents using in-silico approach.
Melanoma
Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas.
Mouth Neoplasms
The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer.
Multiple Myeloma
Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.
Myelodysplastic Syndromes
4SC-202 induces apoptosis in myelodysplastic syndromes and the underlying mechanism.
Neoplasm Metastasis
Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1.
Neoplasms
A dual role of dLsd1 in oogenesis: regulating developmental genes and repressing transposons.
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposing.
Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines.
Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer.
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
High expression of the histone demethylase LSD1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer.
Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells.
Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.
Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.
Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade.
Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1?-dependent pathway.
KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer.
KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.
LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors.
LSD1 inhibition suppresses the growth of clear cell renal cell carcinoma via upregulating P21 signaling.
LSD1 Overexpression Is Associated with Poor Prognosis in Basal-Like Breast Cancer, and Sensitivity to PARP Inhibition.
LSD1/KDM1A inhibitors in clinical trials: advances and prospects.
LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target.
Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway.
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.
Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor.
Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties.
Nuclear import of human histone lysine-specific demethylase LSD1.
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Positive Expression of LSD1 and Negative Expression of E-cadherin Correlate with Metastasis and Poor Prognosis of Colon Cancer.
Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer.
Simultaneous Inhibition of LSD1 and TGF? Enables Eradication of Poorly Immunogenic Tumors with Anti-PD-1 Treatment.
Targeted DNA oxidation by LSD1-SMAD2/3 primes TGF-?1/ EMT genes for activation or repression.
Targeting Histone Lysine Demethylase LSD1/KDM1A as a New Avenue for Cancer Therapy.
Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy.
Targeting KDM1A attenuates Wnt/?-catenin signaling pathway to eliminate sorafenib-resistant stem-like cells in hepatocellular carcinoma.
Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
The Histone Demethylase LSD1 Inhibits Tumor Cell Immunogenicity.
The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer.
The histone demethylase LSD1 is required for estrogen-dependent S100A7 gene expression in human breast cancer cells.
The Lysine Demethylase dKDM2 Is Non-essential for Viability, but Regulates Circadian Rhythms in Drosophila.
The Pseudogene DUXAP8 Promotes Non-small-cell Lung Cancer Cell Proliferation and Invasion by Epigenetically Silencing EGR1 and RHOB.
Wnt3a-dependent and -independent protein interaction networks of chromatin-bound ?-catenin in mouse embryonic stem cells.
Nervous System Diseases
Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
Neuroblastoma
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.
Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway.
Neurodegenerative Diseases
Targeting Histone Demethylase LSD1/KDM1a in Neurodegenerative Diseases.
Prostatic Neoplasms
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.
Retinoblastoma
Cell cycle association of the retinoblastoma protein Rb and the histone demethylase LSD1 with the Epstein-Barr virus latency promoter Cp.
Stomach Neoplasms
Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1.
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.
Teratocarcinoma
New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells.
Tongue Neoplasms
High expression of the histone demethylase LSD1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer.
Triple Negative Breast Neoplasms
Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Uterine Cervical Neoplasms
Lysine-specific histone demethylase 1A (LSD1) in cervical cancer.
Virus Diseases
Correction: Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation.
[histone h3]-n6,n6-dimethyl-l-lysine4 fad-dependent demethylase deficiency
Histone Demethylase LSD1 Deficiency during High Salt Diet is Associated with Enhanced Vascular Contraction, Altered NO-cGMP Relaxation Pathway, and Hypertension.