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Information on EC 1.14.99.58 - heme oxygenase (biliverdin-IX-beta and delta-forming)

for references in articles please use BRENDA:EC1.14.99.58

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IUBMB Comments

The enzyme, characterized from the bacterium Pseudomonas aeruginosa, differs from EC 1.14.15.20, heme oxygenase (biliverdin-producing, ferredoxin), in that the heme substrate is rotated by approximately 110 degrees within the active site, resulting in cleavage at a different part of the ring. It forms a mixture of about 70% biliverdin-IX-δ and 30% biliverdin-IX-β.

The enzyme appears in viruses and cellular organisms

Synonyms
biliverdin IXbeta/delta-selective heme oxygenase, BphO, heme-PigA heme oxygenase, heme-PigA(HO), HemO, PigA, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-beta + CO + Fe2+ + 3 acceptor + 3 H2O
show the reaction diagram
(2)
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protoheme + 3 reduced acceptor + 3 O2 = biliverdin-IX-delta + CO + Fe2+ + 3 acceptor + 3 H2O
show the reaction diagram
(1)
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protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = biliverdin + Fe2+ + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H2O
show the reaction diagram
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