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Information on EC 1.14.99.54 - lytic cellulose monooxygenase (C1-hydroxylating)

for references in articles please use BRENDA:EC1.14.99.54

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IUBMB Comments

This copper-containing enzyme, found in fungi and bacteria, cleaves cellulose in an oxidative manner. The cellulose fragments that are formed contain a D-glucono-1,5-lactone residue at the reducing end, which hydrolyses quickly and spontaneously to the aldonic acid. The electrons are provided in vivo by the cytochrome b domain of EC 1.1.99.18, cellobiose dehydrogenase (acceptor) . Ascorbate can serve as the electron donor in vitro.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
lytic polysaccharide monooxygenase, cbp21, cel61a, aa9 lpmo, cel61b, lpmo9c, lpmo9d, lpmo9a, pagh61b, pslpmoa, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[(1->4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = [(1->4)-beta-D-glucosyl]m-1-(1->4)-D-glucono-1,5-lactone + [(1->4)-beta-D-glucosyl]n + acceptor + H2O
show the reaction diagram
PATHWAY SOURCE
PATHWAYS