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Information on EC 1.14.99.48 - heme oxygenase (staphylobilin-producing)

for references in articles please use BRENDA:EC1.14.99.48

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IUBMB Comments

This enzyme, which is found in some pathogenic bacteria, is involved in an iron acquisition system that catabolizes the host's hemoglobin. The two enzymes from the bacterium Staphylococcus aureus, encoded by the isdG and isdI genes, produce 67.5 % and 56.2 % δ-staphylobilin, respectively.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

Synonyms
heme oxidase, haem oxidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
protoheme + 5 reduced acceptor + 4 O2 = beta-staphylobilin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
show the reaction diagram
(2)
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protoheme + 5 reduced acceptor + 4 O2 = delta-staphylobilin + Fe2+ + formaldehyde + 5 acceptor + 4 H2O
show the reaction diagram
(1)
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