Disease on EC 1.14.99.38 - cholesterol 25-hydroxylase and Organism(s) Homo sapiens and UniProt Accession P11712

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DISEASE
TITLE OF PUBLICATION
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Adrenoleukodystrophy
Exogenous Addition of 25-Hydroxycholesterol Reduces Level of Very Long-Chain Fatty Acids in X-Linked Adrenoleukodystrophy.
Alzheimer Disease
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
Arthritis
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Atherosclerosis
Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.
KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility.
Bacterial Infections
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Breast Neoplasms
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
Central Nervous System Diseases
Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients.
cholesterol 25-hydroxylase deficiency
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Colitis
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.
Encephalomyelitis
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Encephalomyelitis, Autoimmune, Experimental
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Gastroenteritis
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Gastroenteritis, Transmissible, of Swine
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Glioblastoma
On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment.
Hepatitis C
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Herpes Simplex
Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein.
Infections
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
A balanced game: chicken macrophage response to ALV-J infection.
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.
Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms.
Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol.
Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti.
Endogenous Retrovirus ev21 Dose Not Recombine with ALV-J and Induces the Expression of ISGs in the Host.
Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry.
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages.
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Porcine reproductive and respiratory syndrome virus E protein degrades porcine cholesterol 25-hydroxylase via the ubiquitin-proteasome pathway.
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol.
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Influenza, Human
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
Insulin Resistance
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Liver Neoplasms
Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression.
Malaria
Malaria infection alters the expression of hepatobiliary and placental drug transporters in pregnant mice.
Melanoma
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene.
Multiple Sclerosis
Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Neoplasm Metastasis
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Neoplasms
Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies.
Helicobacter hepaticus-Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response.
IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages.
Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver.
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.
Neuromyelitis Optica
Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Non-alcoholic Fatty Liver Disease
Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease.
Obesity
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Obesity, Metabolically Benign
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Osteoarthritis
The CH25H-CYP7B1-ROR? axis of cholesterol metabolism regulates osteoarthritis.
Paralysis
Functional coupling of ATP binding cassette transporter Abcb6 to Cytochrome P450 expression and activity in liver.
Porcine Reproductive and Respiratory Syndrome
Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms.
Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.
Porcine reproductive and respiratory syndrome virus E protein degrades porcine cholesterol 25-hydroxylase via the ubiquitin-proteasome pathway.
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Pseudorabies
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.
Pulmonary Disease, Chronic Obstructive
25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-?B dependent pathway.
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.
Reoviridae Infections
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Reperfusion Injury
The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Sarcoma, Experimental
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.
Spinal Cord Injuries
Macrophage Migration Inhibitory Factor Promotes Chemotaxis of Astrocytes through Regulation of Cholesterol 25-Hydroxylase Following Rat Spinal Cord Injury.
Viremia
Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish.
Virus Diseases
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.
Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Interferons: Reprogramming the Metabolic Network against Viral Infection.
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol.
Zika Virus Infection
25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.
IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages.