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Information on EC 1.14.99.1 - prostaglandin-endoperoxide synthase and Organism(s) Rattus norvegicus and UniProt Accession Q63921

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IUBMB Comments
This enzyme acts both as a dioxygenase and as a peroxidase.
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q63921
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The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
cox-2, cyclooxygenase, cyclooxygenase-2, cox-1, cyclooxygenase 2, ptgs2, pghs-2, cyclooxygenase-1, prostaglandin synthetase, pghs-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cyclooxygenase-1b
-
PG-endoperoxide synthetase
-
prostaglandin-endoperoxide synthase 1
isoform
putative cyclooxygenase-3
-
(PG)H synthase
-
-
-
-
cyclooxygenase
-
-
-
-
fatty acid cyclooxygenase
-
-
-
-
PG synthetase
-
-
-
-
PG-endoperoxide synthetase
-
prostaglandin endoperoxide synthetase
-
-
-
-
prostaglandin G/H synthase
-
-
-
-
prostaglandin synthase
-
-
-
-
prostaglandin synthase-2
-
-
-
-
prostaglandin synthetase
-
-
-
-
prostaglandin-endoperoxide synthase 1
-
-
prostaglandin-endoperoxide synthase 2
PTGS2
synthase, prostaglandin
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
reduction
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
This enzyme acts both as a dioxygenase and as a peroxidase.
CAS REGISTRY NUMBER
COMMENTARY hide
39391-18-9
-
9055-65-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
arachidonate + AH2 + O2
prostaglandin H2 + A + H2O
show the reaction diagram
-
-
-
?
arachidonate + AH2 + O2
prostaglandin H2 + A + H2O
show the reaction diagram
arachidonate + electron donor + O2
prostaglandin H2 + oxidized electron donor + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the expression of PGHS-2 may be involved in inhibiting progesterone production
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
arachidonate + AH2 + O2
prostaglandin H2 + A + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
the expression of PGHS-2 may be involved in inhibiting progesterone production
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-hydroxybutyric acid
-
weak
acetoacetic acid
-
weak
Butyric acid
-
-
crotonic acid
-
-
DL-Propanolol
-
-
fatty acid
-
of low molecular mass
indomethacin
-
inhibition in gastrointestinal tissues
N-[2-cyclohexyloxy-4-nitrophenyl]methanesulfonamide
-
little inhibition in gastrointestinal tissues
propionic acid
-
-
valeryl salicylate
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dopamine
-
-
epinephrine
-
-
norepinephrine
-
-
additional information
-
stimulation of enzyme in crude extract by some amines
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
significant increase in mRNA for PGHS-2 after treatment with prostaglandin F2alpha. PGHS-1 mRNA content remains unchanged
Manually annotated by BRENDA team
-
caput and cauda
Manually annotated by BRENDA team
-
periovulatory granulosa cell
Manually annotated by BRENDA team
-
anterior prostate
Manually annotated by BRENDA team
-
somatic and spermatogenic cells
Manually annotated by BRENDA team
additional information
-
distribution of isozymes 1,2 in gastrointestinal tissues
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
periovulatory expression of the Ptgs2 gene is essential for ovulation
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PGH1_RAT
602
0
69032
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
72000
isozyme PTGS-2
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
COX-1b, expression in COS-7 cells
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
transplantation of hepatocytes induces hepatic expression of prostaglandin-endoperoxide synthase isoform 1 (5fold)
isozyme Ptgs2 transcript level significantly increases at 2 and 4 h after the deciduogenic stimulus with sesame oil is given, and the levels return to prestimulated levels at 8, 16, and 32 h. In contrast to isoform PTGS1 protein levels, PTGS2 protein is significantly higher at 8 h and remains elevated at 16 and 32 h. PTGS2 protein levels are significantly higher in stimulated endometrium at 8 and 32 h than in nonstimulated endometrium
luteinized hormone induces prostaglandin-endoperoxide synthase 2 expression in periovulatory granulosa cells, the induction in part results from Runt-related transcription factor 1-mediated transactivation of the Ptgs2 promoter
-
transplantation of hepatocytes induces hepatic expression of prostaglandin-endoperoxide synthase isoform 2 (2.8fold)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ryan, J.; Davis, G.
Inhibition of prostaglandin synthase by some low molecular mass fatty acids
Biochem. Soc. Trans.
16
398-399
1988
Rattus norvegicus
-
Manually annotated by BRENDA team
Pace-Asciak, C.
Prostaglandin synthetase activity in the rat stomach fundus. Activation by L-norepinephrine and related compounds
Biochim. Biophys. Acta
280
161-171
1972
Rattus norvegicus
Manually annotated by BRENDA team
Kargman, S.; Charleson, S.; Cartwright, M.; Frank, J.; Riendeau, D.; Mancini, J.; Evans, J.; O'Neill, G.
Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts
Gastroenterology
111
445-454
1996
Canis lupus familiaris, Homo sapiens, Macaca mulatta, Rattus norvegicus, Saimiri sciureus
Manually annotated by BRENDA team
Narayansingh, R.M.; Senchyna, M.; Vijayan, M.M.; Carlson, J.C.
Expression of prostaglandin G/H synthase (PGHS) and heat shock protein-70 (HSP-70) in the corpus luteum (CL) of prostaglandin F2 alpha-treated immature superovulated rats
Can. J. Physiol. Pharmacol.
82
363-371
2004
Rattus norvegicus
Manually annotated by BRENDA team
Snipes, J.A.; Kis, B.; Shelness, G.S.; Hewett, J.A.; Busija, D.W.
Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat
J. Pharmacol. Exp. Ther.
313
668-676
2005
Rattus norvegicus (Q63921)
Manually annotated by BRENDA team
Winnall, W.R.; Ali, U.; Obryan, M.K.; Hirst, J.J.; Whiley, P.A.; Muir, J.A.; Hedger, M.P.
Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis
Biol. Reprod.
76
759-768
2007
Rattus norvegicus
Manually annotated by BRENDA team
Liu, J.; Park, E.S.; Jo, M.
Runt-related transcription factor 1 regulates luteinized hormone-induced prostaglandin-endoperoxide synthase 2 expression in rat periovulatory granulosa cells
Endocrinology
150
3291-3300
2009
Rattus norvegicus
Manually annotated by BRENDA team
Enami, Y.; Bandi, S.; Kapoor, S.; Krohn, N.; Joseph, B.; Gupta, S.
Hepatic stellate cells promote hepatocyte engraftment in rat liver after prostaglandin-endoperoxide synthase inhibition
Gastroenterology
136
2356-2364
2009
Rattus norvegicus (P35355), Rattus norvegicus (Q63921)
Manually annotated by BRENDA team
Gillio-Meina, C.; Phang, S.H.; Mather, J.P.; Knight, B.S.; Kennedy, T.G.
Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization
Reproduction
137
537-552
2009
Rattus norvegicus (P35355), Rattus norvegicus (Q63921)
Manually annotated by BRENDA team