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Information on EC 1.14.20.15 - L-threonyl-[L-threonyl-carrier protein] 4-chlorinase

for references in articles please use BRENDA:EC1.14.20.15

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IUBMB Comments

The enzyme, characterized from the bacterium Pseudomonas syringae, participates in syringomycin E biosynthesis. The enzyme is a specialized iron(II)/2-oxoglutarate-dependent oxygenase that catalyses the chlorination of its substrate in a reaction that requires oxygen, chloride ions, ferrous iron and 2-oxoglutarate.

The expected taxonomic range for this enzyme is: Pseudomonas syringae
  • 1.14.20.15
  • non-heme
  • ferryl
  • rebound
  • halide
  • alphakg-dependent
  • unactivated
  • chemoselectivity
  • alphakg
  • ironii
  • high-spin
  • alpha-ketoglutarate-dependent
Reaction Schemes
an L-threonyl-[L-threonyl-carrier protein]
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+
+
=
a 4-chloro-L-threonyl-[L-threonyl-carrier protein]
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+
+

Synonyms
syrb2, aliphatic halogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an L-threonyl-[L-threonyl-carrier protein] + 2-oxoglutarate + O2 + Cl- = a 4-chloro-L-threonyl-[L-threonyl-carrier protein] + succinate + CO2 + H2O
show the reaction diagram
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