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Information on EC 1.14.19.42 - palmitoyl-[glycerolipid] 7-desaturase and Organism(s) Arabidopsis thaliana and UniProt Accession Q949X0

for references in articles please use BRENDA:EC1.14.19.42
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IUBMB Comments
The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q949X0
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Word Map
  • 1.14.19.42
  • signal-regulated
  • lipopolysaccharide
  • lps-induced
  • nf-kappab
  • caspase-3
  • stress-activated
  • collagen
  • cyclooxygenase-2
  • lps-stimulated
  • 3-kinase
  • prostaglandin
  • mapk-dependent
  • dominant-negative
  • osteoblast
  • toll-like
  • factor-alpha
  • p38mapk
  • mapk-mediated
  • phosphatidylinositol
  • metalloproteinase
  • anti-apoptotic
  • parp
  • kinase-dependent
  • lipopolysaccharide-induced
  • p38alpha
  • microglial
  • il-1beta
  • osteoclastogenesis
  • factor-kappa
  • phosphatase-1
  • phospho-p38
  • wortmannin
  • smads
  • anisomycin
  • extracellular-regulated
  • vemurafenib
  • lps-activated
  • phospho-erk1/2
  • kinase-activated
  • phospho-erk
  • dual-specificity
  • egf-induced
  • phospho-specific
  • brafv600e
  • map-kinase
  • p90rsk
  • extracellular-signal-regulated
  • rankl
  • rankl-induced
  • ikappab-alpha
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
fad5 desaturase, palmitoyl-monogalactosyldiacylglycerol delta7-desaturase, 16:0delta7 desaturase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
16:0DELTA7 desaturase
-
FAD5 desaturase
-
palmitoyl-monogalactosyldiacylglycerol DELTA7-desaturase
-
FAD5
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
1-acyl-2-palmitoyl-[glycerolipid],ferredoxin:oxygen oxidoreductase (7,8-cis-dehydrogenating)
The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-acyl-2-palmitoyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-acyl-2-[(7Z)-hexadec-7-enoyl]-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-acyl-2-palmitoyl-[glycerolipid] + reduced ferredoxin [iron-sulfur] cluster + O2 + H+
1-acyl-2-[(7Z)-hexadec-7-enoyl]-[glycerolipid] + oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme catalyzes the first step in the synthesis of 7,10,13-hexadecatrienoic acid in monogalactosyldiacylglycerol
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ADS3_ARATH
371
2
42580
Swiss-Prot
Chloroplast (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
coexpressed with cucumber monogalactosyldiacylglycerol synthase in Saccharomyces cerevisiae OLE1 strain
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in non-acclimated toc132toc120+/- mutant plants, the FAD5 gene is repressed and this correlates with decreased levels of 7,10,13-hexadecatrienoic acid. In cold-acclimated mutant, the FAD5 gene is upregulated and there is a small increase in 16:3 levels relative to the non-acclimated mutant plants
in non-acclimated toc132toc120+/- mutant plants, the FAD5 gene is repressed and this correlates with decreased levels of 7,10,13-hexadecatrienoic acid. In cold-acclimated mutant, the FAD5 gene is upregulated and there is a small increase in 7,10,13-hexadecatrienoic acid levels relative to the non-acclimated mutant plants
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Heilmann, I.; Pidkowich, M.S.; Girke, T.; Shanklin, J.
Switching desaturase enzyme specificity by alternate subcellular targeting
Proc. Natl. Acad. Sci. USA
101
10266-10271
2004
Arabidopsis thaliana (Q949X0)
Manually annotated by BRENDA team
Falcone, D.L.; Ogas, J.P.; Somerville, C.R.
Regulation of membrane fatty acid composition by temperature in mutants of Arabidopsis with alterations in membrane lipid composition
BMC Plant Biol.
4
17
2004
Arabidopsis thaliana (Q949X0)
Manually annotated by BRENDA team
Heilmann, I.; Mekhedov, S.; King, B.; Browse, J.; Shanklin, J.
Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol DELTA7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype
Plant Physiol.
136
4237-4245
2004
Arabidopsis thaliana (Q949X0)
Manually annotated by BRENDA team
Afitlhile, M.; Duffield-Duncan, K.; Fry, M.; Workman, S.; Hum-Musser, S.; Hildebrand, D.
The toc132toc120 heterozygote mutant of Arabidopsis thaliana accumulates reduced levels of hexadecatrienoic acid
Plant Physiol. Biochem.
96
426-435
2015
Arabidopsis thaliana (Q949X0), Arabidopsis thaliana
Manually annotated by BRENDA team