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Information on EC 1.14.19.42 - palmitoyl-[glycerolipid] 7-desaturase

for references in articles please use BRENDA:EC1.14.19.42

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IUBMB Comments

The enzyme introduces a cis double bond at carbon 7 of a palmitoyl group attached to the sn-2 position of glycerolipids. The enzyme from the plant Arabidopsis thaliana is specific for palmitate in monogalactosyldiacylglycerol.

The enzyme appears in viruses and cellular organisms
  • 1.14.19.42
  • signal-regulated
  • lipopolysaccharide
  • lps-induced
  • nf-kappab
  • caspase-3
  • stress-activated
  • collagen
  • cyclooxygenase-2
  • lps-stimulated
  • 3-kinase
  • prostaglandin
  • mapk-dependent
  • dominant-negative
  • osteoblast
  • toll-like
  • factor-alpha
  • p38mapk
  • mapk-mediated
  • phosphatidylinositol
  • metalloproteinase
  • anti-apoptotic
  • parp
  • kinase-dependent
  • lipopolysaccharide-induced
  • p38alpha
  • microglial
  • il-1beta
  • osteoclastogenesis
  • factor-kappa
  • phosphatase-1
  • phospho-p38
  • wortmannin
  • smads
  • anisomycin
  • extracellular-regulated
  • vemurafenib
  • lps-activated
  • phospho-erk1/2
  • kinase-activated
  • phospho-erk
  • dual-specificity
  • egf-induced
  • phospho-specific
  • brafv600e
  • map-kinase
  • p90rsk
  • extracellular-signal-regulated
  • rankl
  • rankl-induced
  • ikappab-alpha
Reaction Schemes

Synonyms
fad5 desaturase, 16:0delta7 desaturase, palmitoyl-monogalactosyldiacylglycerol delta7-desaturase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 1-acyl-2-palmitoyl-[glycerolipid] + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = a 1-acyl-2-[(7Z)-hexadec-7-enoyl]-[glycerolipid] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(7Z,10Z,13Z)-hexadecatrienoate biosynthesis, glycolipid desaturation
Highest Expressing Human Cell Lines
Cell Line Links Gene Links