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Information on EC 1.14.19.41 - sterol 22-desaturase

for references in articles please use BRENDA:EC1.14.19.41
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IUBMB Comments
A heme-thiolate protein (P-450). The enzyme, found in yeast and plants, catalyses the introduction of a double bond between the C-22 and C-23 carbons of certain sterols. In yeast the enzyme acts on ergosta-5,7,24(28)-trien-3beta-ol, a step in the biosynthesis of ergosterol. The enzyme from the plant Arabidopsis thaliana acts on sitosterol and 24-epi-campesterol, producing stigmasterol and brassicasterol, respectively.
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The enzyme appears in viruses and cellular organisms
Synonyms
C-22 sterol desaturase, CTP61, CYP61, CYP710A, CYP710A1, CYP710A11, CYP710A13, CYP710A14, CYP710A2, CYP710A4, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
ergosta-5,7,24(28)-trien-3beta-ol + NADPH + H+ + O2 = ergosta-5,7,22,24(28)-tetraen-3-beta-ol + NADP+ + 2 H2O
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