Information on EC 1.14.19.37 - acyl-CoA 5-desaturase

for references in articles please use BRENDA:EC1.14.19.37
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
1.14.19.37
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RECOMMENDED NAME
GeneOntology No.
acyl-CoA 5-desaturase
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REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H2O
show the reaction diagram
(1)
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(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H2O
show the reaction diagram
(2)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
juniperonate biosynthesis
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sciadonate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating)
The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
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the enzyme is required for the synthesis of sciadonic acid and juniperonic acid
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + H2O
show the reaction diagram
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?
(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + H2O
show the reaction diagram
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?
eicosatrienoyl-CoA + reduced acceptor + O2
? + acceptor + H2O
show the reaction diagram
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?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + H2O
show the reaction diagram
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?
(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + H2O
show the reaction diagram
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?
eicosatrienoyl-CoA + reduced acceptor + O2
? + acceptor + H2O
show the reaction diagram
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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does not contain a cytochrome b5 domain
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.006
Eicosatrienoyl-CoA
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at pH 7.2 and 22°C
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Arabidopsis thaliana
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LINKS TO OTHER DATABASES (specific for EC-Number 1.14.19.37)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)