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EC Tree
IUBMB Comments The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase.
Word Map
1.14.19.37
gryllus
cricket
assimilis
technologists
midgut
The enzyme appears in viruses and cellular organisms
Synonyms
acyl-CoA 5-desaturase (non-methylene-interrupted), acyl-coenzyme A C20 DELTA5-desaturase, AL10, AL21, C20 DELTA5cis-desaturase, DELTA5-desaturase,
more
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acyl-CoA 5-desaturase (non-methylene-interrupted)
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acyl-coenzyme A C20 DELTA5-desaturase
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C20 DELTA5cis-desaturase
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(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + 2 H2O
(1)
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(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2 = (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + 2 H2O
(2)
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acyl-CoA,acceptor:oxygen oxidoreductase (5,6 cis-dehydrogenating)
The enzyme, characterized from the plant Anemone leveillei, introduces a cis double bond at carbon 5 of acyl-CoAs that do not contain a double bond at position 8. In vivo it forms non-methylene-interrupted polyunsaturated fatty acids such as sciadonate and juniperonate. When expressed in Arabidopsis thaliana the enzyme could also act on unsaturated substrates such as palmitoyl-CoA. cf. EC 1.14.19.44, acyl-CoA (8-3)-desaturase.
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(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + H2O
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(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + H2O
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eicosatrienoyl-CoA + reduced acceptor + O2
? + acceptor + H2O
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?
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(11Z,14Z)-icosa-11,14-dienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z)-icosa-5,11,14-trienoyl-CoA + acceptor + H2O
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?
(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + reduced acceptor + O2
(5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoyl-CoA + acceptor + H2O
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eicosatrienoyl-CoA + reduced acceptor + O2
? + acceptor + H2O
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?
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additional information
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does not contain a cytochrome b5 domain
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0.006
Eicosatrienoyl-CoA
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at pH 7.2 and 22°C
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brenda
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brenda
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brenda
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brenda
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brenda
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metabolism
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the enzyme is required for the synthesis of sciadonic acid and juniperonic acid
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FAT4_CAEEL
447
4
52348
Swiss-Prot
other Location (Reliability: 1 )
AL21_ANELE
321
3
37831
Swiss-Prot
other Location (Reliability: 1 )
AL10_ANELE
312
3
36952
Swiss-Prot
other Location (Reliability: 1 )
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expressed in Arabidopsis thaliana
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Pugh, E.L.; Kates, M.
The dietary regulation of acyltransferase and desaturase activities in microsomal membranes of rat liver
Lipids
19
48-55
1984
Rattus norvegicus
brenda
Sayanova, O.; Haslam, R.; Caleron, M.; Napier, J.
Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: Identification of an acyl-coenzyme A C20 DELTA5-desaturase responsible for the synthesis of sciadonic acid
Plant Physiol.
144
455-467
2007
Anemone leveillei
brenda
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