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Disease on EC 1.14.19.30 - acyl-lipid (8-3)-desaturase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Coronary Syndrome
Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.
Atherosclerosis
Effects of compound-326, a selective delta-5 desaturase inhibitor, in ApoE knockout mice with two different protocols for atherosclerosis development.
Breast Neoplasms
Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional delta-5-desaturase siRNA nanoparticle for breast cancer therapy.
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Carcinoma, Hepatocellular
Linoleate and linolenate desaturation by rat hepatoma cells.
Cardiovascular Diseases
Novel Heterocyclic Compounds as Delta-5-Desaturase Inhibitors for Treating Metabolic and Cardiovascular Diseases.
Colitis, Ulcerative
Modulation in delta 9, delta 6, and delta 5 fatty acid desaturase activity in the human intestinal CaCo-2 cell line.
Colonic Neoplasms
Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase.
Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.
Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs.
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2.
Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-?-linolenic acid for colon cancer suppression.
Coronary Artery Disease
Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.
Dermatitis, Atopic
Erythrocyte and plasma fatty acid patterns in dogs with atopic dermatitis and healthy dogs in the same household.
Diabetes Mellitus
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus.
Diabetes Mellitus, Type 2
Desaturation function does not decline after menopause in human females.
Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus.
Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes.
Response to comment on Imamura et al. Plasma polyunsaturated fatty acid profile and delta-5 desaturase activity are altered in patients with type 2 diabetes. Metabolism 2014;63(11):1432-8.
The effect of FADS2 gene rs174583 polymorphism on desaturase activities, fatty acid profile, insulin resistance, biochemical indices, and incidence of type 2 diabetes.
Diabetes, Gestational
Longitudinal circulating concentrations of long-chain polyunsaturated fatty acids in the third trimester of pregnancy in gestational diabetes.
Dyslipidemias
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Fibrosarcoma
Eicosadiynoic acid: a non-toxic inhibitor of multiple enzymatic steps in the production of icosanoids from arachidonic acid.
Heart Failure
Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency".
Hyperinsulinism
Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.
Hypertension
Effect of sucrose addition to drinking water, that induces hypertension in the rats, on liver microsomal Delta9 and Delta5-desaturase activities.
Hypertriglyceridemia
Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity.
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Infections
Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection.
Inflammatory Bowel Diseases
Modulation in delta 9, delta 6, and delta 5 fatty acid desaturase activity in the human intestinal CaCo-2 cell line.
Insulin Resistance
A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
Association of Changes in Body Fatness and Fatty Acid Composition of Plasma Phospholipids During Early Puberty in Japanese Children.
Characteristics of obese children with low content of arachidonic acid in plasma lipids.
Decreased Liver Fatty Acid Delta-6 and Delta-5 Desaturase Activity in Obese Patients.
Dietary fat and insulin action in humans.
Effects of fish oil alone and combined with long chain (n-6) fatty acids on some coronary risk factors in male subjects.
Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity.
Effects of two-months balanced diet in metabolically healthy obesity: lipid correlations with gender and BMI-related differences.
Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study.
Lower estimates of delta-5 desaturase and elongase activity are related to adverse profiles for several metabolic risk factors in young Japanese women.
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Ketosis
Short-term diabetic ketosis alters n-6 polyunsaturated fatty acid content in plasma phospholipids.
Liver Cirrhosis
Advanced Liver Fibrosis Is Independently Associated with Palmitic Acid and Insulin Levels in Patients with Non-Alcoholic Fatty Liver Disease.
Lung Neoplasms
2D Nanomaterial, Ti3C2 MXene-Based Sensor to Guide Lung Cancer Therapy and Management.
Iminodibenzyl redirected cyclooxygenase-2 catalyzed dihomo-?-linolenic acid peroxidation pattern in lung cancer.
Malnutrition
One-Carbon Metabolism and Lipid Metabolism in DOHaD.
Metabolic Syndrome
Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.
Design, synthesis, and in vivo activity of novel inhibitors of delta-5 desaturase for the treatment of metabolic syndrome.
Docosahexaenoic Acid Content in Plasma Phospholipids and Desaturase Indices in Obese Children.
Omega-6 polyunsaturated fatty acids, serum zinc, delta-5- and delta-6-desaturase activities and incident metabolic syndrome.
Myocardial Infarction
The serum cholesterol ester fatty acid composition but not the serum concentration of alpha tocopherol predicts the development of myocardial infarction in 50-year-old men: 19 years follow-up.
Neoplasms
Delta-5-desaturase: A novel therapeutic target for cancer management.
Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase.
EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation.
Erratum to "Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells" [Redox Biol. 11 (2017) 653-662].
Iminodibenzyl induced redirected COX-2 activity inhibits breast cancer progression.
Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Knockdown of delta-5-desaturase promotes the anti-cancer activity of dihomo-?-linolenic acid and enhances the efficacy of chemotherapy in colon cancer cells expressing COX-2.
Prostate tumor growth can be modulated by dietarily targeting the 15-lipoxygenase-1 and cyclooxygenase-2 enzymes.
Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-?-linolenic acid for colon cancer suppression.
The effect of chemical hepatocarcinogenesis on liver phospholipid composition in rats fed N-6 and N-3 fatty acid-supplemented diets.
Tissue distribution and metabolism of gamma-linolenoyl-3-eicosapentaenoyl propane diol enterally or intravenously administered to mice bearing human pancreatic carcinomas.
Neuroblastoma
Differential effects of steroids on the synthesis of polyunsaturated fatty acids by human neuroblastoma cells.
Obesity
Dietary fats, membrane phospholipids and obesity.
Obesity, Abdominal
Abdominal adiposity is associated with fatty acid desaturase activity in boys: Implications for C-reactive protein and insulin resistance.
Overweight
Palmitoleic and Dihomo-?-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children.
Pancreatic Neoplasms
Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.
EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation.
Inhibition of cancer migration and invasion by knocking down delta-5-desaturase in COX-2 overexpressed cancer cells.
Knockdown delta-5-desaturase promotes the formation of a novel free radical byproduct from COX-catalyzed ?-6 peroxidation to induce apoptosis and sensitize pancreatic cancer cells to chemotherapy drugs.