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Information on EC 1.14.19.21 - cholesterol 7-desaturase

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IUBMB Comments
The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase. In insects it participates in the the biosythesis of ecdysteroid hormones. The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin. The enzyme differs from regular desaturases, such as EC 1.14.19.20, 7-sterol 5(6)-desaturase, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases.
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The enzyme appears in viruses and cellular organisms
Synonyms
pmnvd, des7p, cholesterol 7,8-dehydrogenase, daf-36/neverland, sterol c7(8)-desaturase, c-7 cholesterol desaturase, rieske domain oxygenase neverland, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cholesterol + O2 + NAD(P)H + H+ = cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O
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