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Information on EC 1.14.19.20 - DELTA7-sterol 5(6)-desaturase
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1.14.19.20 DELTA7-sterol 5(6)-desaturaseIUBMB Comments
This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.
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Word Map
- 1.14.19.20
- ergosterol
-
desaturation
- fluconazole
- 7-dehydrocholesterol
- azole
-
desaturases
-
azole-resistant
-
smith-lemli-opitz
- voriconazole
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
2
+
+
2
=
+
2
+
2
Synonyms
erg3p, c-5 sterol desaturase, 5-des, fvc5sd, erg 3, lathosterol 5-desaturase, sterol c5-desaturase, sterol-c5-desaturase, des5a, delta7-sterol-c5(6)-desaturase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5-DES
5alpha-cholest-7-en-3beta-ol:oxygen DELTA5-oxidoreductase
-
-
-
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C-5 sterol desaturase
C-5(6) sterol desaturase
Delta-7-sterol 5-desaturase
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-
-
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DELTA7-sterol 5-desaturase
DELTA7-sterol DELTA5-dehydrogenase
DELTA7-sterol-C-5-desaturase
DELTA7-sterol-C5(6)-desaturase
DES5A
Des5Ap
EC 1.14.21.6
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-
formerly
-
ERG3
Erg3p
Lathosterol 5-desaturase
lathosterol oxidase
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-
-
-
oxidase, lathosterol
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-
-
-
Sc5d
sterol C5-desaturase
sterol DELTA5,6-desaturase
sterol DELTA7-reductase
Sterol-C5-desaturase
C-5 sterol desaturase
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-
-
-
DELTA7-sterol 5-desaturase
-
-
-
-
DELTA7-sterol DELTA5-dehydrogenase
-
-
-
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Lathosterol 5-desaturase
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-
-
-
Sterol-C5-desaturase
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-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a DELTA7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a DELTA5,7-sterol + 2 ferricytochrome b5 + 2 H2O
a DELTA7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a DELTA5,7-sterol + 2 ferricytochrome b5 + 2 H2O
enzyme initiates oxidation by cleavage of the chemically activated C6alpha-H bond, proposed mechanism
-
a DELTA7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a DELTA5,7-sterol + 2 ferricytochrome b5 + 2 H2O
enzyme initiates oxidation by cleavage of the chemically activated C6alpha-H bond, proposed mechanism
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a DELTA7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ = a DELTA5,7-sterol + 2 ferricytochrome b5 + 2 H2O
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
reduction
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
DELTA7-sterol,ferrocytochrome b5:oxygen oxidoreductase 5,6-dehydrogenating
This enzyme, found in eukaryotic organisms, catalyses the introduction of a double bond between the C5 and C6 carbons of the B ring of Delta7-sterols, to yield the corresponding Delta5,7-sterols. The enzymes from yeast, plants and vertebrates act on avenasterol, episterol, and lathosterol, respectively. The enzyme is located at the endoplasmic reticulum and is membrane bound.
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CAS REGISTRY NUMBER
COMMENTARY
37255-37-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(24Z)-5alpha-stigmast-7,24(241)-dien-3beta-ol + O2 + reduced acceptor
(24Z)-stigmasta-5,7,24(241)-trien-3-beta-ol + acceptor + H2O
-
-
-
?
(3beta,24R)-ergost-7-en-3-ol + ferrocytochrome b5 + O2 + H+
(3beta,24R)-ergosta-5,7-dien-3-ol + ferricytochrome b5 + H2O
-
-
-
-
?
14-methylfecosterol + ferrocytochrome b5 + O2 + H+
14-methylergosta-5,8,24(28)-trien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
?
5alpha-cholest-22-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,22-dien-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
5alpha-cholest-7-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
NADH is more efficient than NADPH
-
-
?
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
? + ferricytochrome b5 + H2O
-
-
-
-
?
5alpha-cholesta-7,22-dien-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-cholestan-3beta-ol + ferrocytochrome b5 + H+ + O2
cholest-5-en-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-ergost-7,24(241)-dien-3beta-ol + O2 + ferrocytochrome b5
ergosta-5,7,24(241)-trien-3beta-ol + H2O2 + ferricytochrome b5
5alpha-ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosterol + ferricytochrome b5 + H2O
5alpha-ergosta-7,24-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24-trien-3beta-ol + ferricytochrome b5 + H2O
5alpha-ergosta-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
a DELTA7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+
a DELTA5,7-sterol + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
cholest-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
cholest-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
-
?
cholesta-7,24-dien-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
7-dehydrodesmosterol + 2 ferricytochrome b5 + 2 H2O
DELTA7-avenasterol + O2 + ferrocytochrome b5
DELTA5,7-avenasterol + H2O + ferricytochrome b5
-
-
-
-
?
DELTA7-campesterol + O2 + ferrocytochrome b5
DELTA5,7-campesterol + H2O + ferricytochrome b5
-
-
-
-
?
DELTA7-sitosterol + O2 + ferrocytochrome b5
DELTA5,7-sitosterol + H2O + ferricytochrome b5
-
-
-
-
?
DELTA7-sterol + ferrocytochrome b5 + O2 + H+
DELTA5,7-sterol + ferricytochrome b5 + H2O
-
-
-
-
?
DELTA7-ststigmast-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
stigmast-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
-
?
episterol + ferrocytochrome b5 + O2 + H+
? + ferricytochrome b5 + H2O
-
-
-
-
?
episterol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24(28)-trien-3beta-ol + ferricytochrome b5 + 2 H2O
episterol + O2 + ferrocytochrome b5
DELTA5,7-episterol + H2O + ferricytochrome b5
-
-
-
-
?
ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosterol + ferricytochrome b5 + 2 H2O
-
-
-
?
ergosta-7,24(28)-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24(28)-trien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
ergosta-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7-dien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
ergosta-8,22,24(28)-trien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,8,22,24(28)-tetraen-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
ergosta-8,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,8,22-trien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
ergosterol + ferrocytochrome b5 + O2 + H+
lanosterol + ferricyctochrome b5 + H2O
-
-
-
-
?
fecosterol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24(28)-trien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
lanosterol + ferrocytochrome b5 + O2 + H+
lanosta-5,8,24-trien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
lathosterol + 2 ferrocytochrome b5 + O2 + 2 H+
7-dehydrocholesterol + 2 ferricytochrome b5 + 2 H2O
lathosterol + ferrocytochrome b5 + O2 + H+
7-dehydrocholesterol + ferricytochrome b5 + H2O
-
-
-
-
?
lathosterol + O2 + ferrocytochrome b5
7-dehydrocholesterol + H2O + ferricytochrome b5
-
-
-
-
?
stigmast-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
stigmast-5,7-dien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
stigmasta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
stigmast-5,7,22-trien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
zymosterol + ferrocytochrome b5 + O2 + H+
cholesta-5,8,24-trien-3beta-ol + ferricyctochrome b5 + H2O
-
-
-
-
?
5alpha-cholest-22-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,22-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-22-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,22-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
i.e. lathosterol
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
i.e. lathosterol
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
i.e. lathosterol
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
enzyme is rather a mixed function oxidase which requires O2 and NAD(P)H for activity, than a dehydrogenase
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
NADPH, 40% of activity with NADH
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
cholesterol biosynthesis
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
cholesterol biosynthesis
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
NADH is more efficient than NADPH
-
-
?
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholesta-7,22-dien-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholesta-7,22-dien-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholestan-3beta-ol + ferrocytochrome b5 + H+ + O2
cholest-5-en-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholestan-3beta-ol + ferrocytochrome b5 + H+ + O2
cholest-5-en-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-ergost-7,24(241)-dien-3beta-ol + O2 + ferrocytochrome b5
ergosta-5,7,24(241)-trien-3beta-ol + H2O2 + ferricytochrome b5
-
-
-
?
5alpha-ergost-7,24(241)-dien-3beta-ol + O2 + ferrocytochrome b5
ergosta-5,7,24(241)-trien-3beta-ol + H2O2 + ferricytochrome b5
-
-
-
?
5alpha-ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosterol + ferricytochrome b5 + H2O
-
-
-
?
5alpha-ergosta-7,22-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosterol + ferricytochrome b5 + H2O
-
-
-
?
5alpha-ergosta-7,24-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24-trien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
?
5alpha-ergosta-7,24-dien-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24-trien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
?
5alpha-ergosta-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
?
5alpha-ergosta-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
ergosta-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
?
cholesta-7,24-dien-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
7-dehydrodesmosterol + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
cholesta-7,24-dien-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
7-dehydrodesmosterol + 2 ferricytochrome b5 + 2 H2O
Mus musculus C57Bl/6N (JM8A3.N1)
-
-
-
-
?
episterol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24(28)-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
-
?
episterol + ferrocytochrome b5 + O2 + H+
ergosta-5,7,24(28)-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
-
?
lanosterol + ferrocytochrome b5 + O2 + H+
? + ferricytochrome b5 + H2O
-
-
-
?
lanosterol + ferrocytochrome b5 + O2 + H+
? + ferricytochrome b5 + H2O
-
-
-
?
lathosterol + 2 ferrocytochrome b5 + O2 + 2 H+
7-dehydrocholesterol + 2 ferricytochrome b5 + 2 H2O
-
-
-
-
?
lathosterol + 2 ferrocytochrome b5 + O2 + 2 H+
7-dehydrocholesterol + 2 ferricytochrome b5 + 2 H2O
Mus musculus C57Bl/6N (JM8A3.N1)
-
-
-
-
?
additional information
?
-
-
enzyme deficiency leads to lathosterolosis, a defect of cholesterol biosynthesis, phenotype, detailed overview
-
-
?
additional information
?
-
-
the enzyme is involved in the post-squalene part of cholesterol biosynthesis
-
-
?
additional information
?
-
-
no activity with 4alpha-methyl-5alpha-cholest-7-en-3beta-ol, 4alpha,14alpha-dimethyl-5alpha-cholest-7-en-3beta-ol, cholestan-3beta-ol and cholest-8-en-3beta-ol
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(3beta,24R)-ergost-7-en-3-ol + ferrocytochrome b5 + O2 + H+
(3beta,24R)-ergosta-5,7-dien-3-ol + ferricytochrome b5 + H2O
-
-
-
-
?
5alpha-cholest-22-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,22-dien-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-cholesta-7,22-dien-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
5alpha-cholestan-3beta-ol + ferrocytochrome b5 + H+ + O2
cholest-5-en-3beta-ol + ferricytochrome b5 + 2 H2O
a DELTA7-sterol + 2 ferrocytochrome b5 + O2 + 2 H+
a DELTA5,7-sterol + 2 ferricytochrome b5 + 2 H2O
-
-
-
?
cholest-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
cholest-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
-
?
DELTA7-sterol + ferrocytochrome b5 + O2 + H+
DELTA5,7-sterol + ferricytochrome b5 + H2O
-
-
-
-
?
DELTA7-ststigmast-7-en-3beta-ol + ferrocytochrome b5 + O2 + H+
stigmast-5,7-dien-3beta-ol + ferricytochrome b5 + H2O
-
-
-
-
?
episterol + ferrocytochrome b5 + O2 + H+
? + ferricytochrome b5 + H2O
-
-
-
-
?
lathosterol + ferrocytochrome b5 + O2 + H+
7-dehydrocholesterol + ferricytochrome b5 + H2O
-
-
-
-
?
lathosterol + O2 + ferrocytochrome b5
7-dehydrocholesterol + H2O + ferricytochrome b5
-
-
-
-
?
5alpha-cholest-22-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,22-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-22-en-3beta-ol + ferrocytochrmoe b5 + H+ + O2
cholesta-5,22-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
cholesterol biosynthesis
-
?
5alpha-cholest-7-en-3beta-ol + 2 ferrocytochrome b5 + O2 + 2 H+
cholesta-5,7-dien-3beta-ol + 2 ferricytochrome b5 + 2 H2O
-
cholesterol biosynthesis
-
?
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholest-7-en-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7-dien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholesta-7,22-dien-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholesta-7,22-dien-3beta-ol + ferrocytochrome b5 + H+ + O2
cholesta-5,7,22-trien-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
?
5alpha-cholestan-3beta-ol + ferrocytochrome b5 + H+ + O2
cholest-5-en-3beta-ol + ferricytochrome b5 + 2 H2O
-
-
-
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5alpha-cholestan-3beta-ol + ferrocytochrome b5 + H+ + O2
cholest-5-en-3beta-ol + ferricytochrome b5 + 2 H2O
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additional information
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enzyme deficiency leads to lathosterolosis, a defect of cholesterol biosynthesis, phenotype, detailed overview
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additional information
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the enzyme is involved in the post-squalene part of cholesterol biosynthesis
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Iron
additional information
additional information
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the enzyme may hold non-heme irons in the catalytic center containing histidine residues
additional information
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the enzyme may hold non-heme irons in the catalytic center containing histidine residues
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(3S,20S)-20-N-(2-methylpropyl)carbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
(3S,20S)-20-N-butylcarbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
(3S,20S)-20-N-pentylcarbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
(3S,20S)-20-N-tert-butylcarbamoylpregn-7-en-3beta-yl acetate
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specific for the enzyme. Prodrug, transformed into the 3beta-hydroxy derivative under in vitro conditions
2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol
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average content of 7-dehydrocholesterol in human primary hepatocytes after 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol treatment is, 34.16 times higher than that in nontreated cells, indicating that DHCR7 is the major target (minor targets are human sterol DELTA14-reductase, sterol DELTA24-reductase, and sterol C5-desaturase). In vitro kinetic measurements show that the half-life of 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol is at least 4.3 h. 2-(4-phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol does not induce CYP3A4 mRNA nor enzyme activity
4,5-dihydroxy-1,3-benzene-disulfonic acid
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trivial name tiron, 0.5 mM, 80% inhibition
alpha-(2,4-dichlorophenyl)-alpha-phenyl-5-pyrimidine methanol
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trivial name triarimol, weak inhibition
lathosterol side chain amides
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synthesis and compound screening, influence of different sterol amides on inhibition of the enzyme, overview, lathosterol-derived amides with larger substituents, e.g. butyl, isobutyl, tert-butyl, pentyl, at the amide nitrogen are selective inhibitors of lathosterol oxidase, overview
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additional information
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cytotoxicity and inhibitor potencies for inhibition of total cholesterol biosynthesis, overview
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additional information
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the enzyme is not affected by N-ethylmaleimide and dithiothreitol
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
squalene and sterol carrier protein
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2fold stimulation of enzyme activity in microsomes, stimulation is lower if microsomes are pretreated with phospholipase A2, acetone powder, 0.05% sodium deoxycholate or 0.2% Triton X-100
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinogenesis
Vitamin D3 Produced by Skin Exposure to UVR Inhibits Murine Basal Cell Carcinoma Carcinogenesis.
Dehydration
FvC5SD overexpression enhances drought tolerance in soybean by reactive oxygen species scavenging and modulating stress-responsive gene expression.
delta7-sterol 5(6)-desaturase deficiency
Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency.
Infections
Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity.
Smith-Lemli-Opitz Syndrome
Quantitative proteomic analysis of inborn errors of cholesterol synthesis: Identification of altered metabolic pathways in DHCR7 and SC5D deficiency.
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