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IUBMB Comments The enzyme, characterized from the plant Calendula officinalis, converts a single cis double bond at position 9 of fatty acids incorporated into glycerolipids into two conjugated trans double bonds at positions 8 and 10.
The enzyme appears in viruses and cellular organisms
Synonyms
Fac2, FADX, FADX-1, FADX-2,
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a linoleoyl-[glycerolipid] + reduced acceptor + O2 = an (8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + 2 H2O
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linoleoyl-lipid,reduced acceptor:oxygen 8,11-allylic oxidase (8E,10E-forming)
The enzyme, characterized from the plant Calendula officinalis, converts a single cis double bond at position 9 of fatty acids incorporated into glycerolipids into two conjugated trans double bonds at positions 8 and 10.
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(6Z,9Z,12Z)-octadec-6,9,12-trienoyl-[glycerolipid] + reduced acceptor + O2
(6Z,9Z,11E,13E)-octadec-6,9,11,13-tetraenoyl -[glycerolipid] + acceptor + H2O
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(9Z)-hexadec-9-enoyl -[glycerolipid] + reduced acceptor + O2
(9Z,12E)-hexadec-9,12-dienoyl-[glycerolipid] + acceptor + H2O
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(9Z)-hexadec-9-enoyl-[glycerolipid] + reduced acceptor + O2
(8Z,10Z)-hexadec-8,10-dienoyl-[glycerolipid] + acceptor + H2O
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weak activity
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(9Z)-octadec-9-enoyl-[glycerolipid] + reduced acceptor + O2
(8Z,10Z)-octadec-8,10-dienoyl-[glycerolipid] + acceptor + H2O
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weak activity
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(9Z)-octadec-9-enoyl-[glycerolipid] + reduced acceptor + O2
(9Z,12E)-octadec-9,12-dienoyl-[glycerolipid] + acceptor + H2O
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(9Z,12Z)-octadec-9,12-dienoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadec-8,10,12-trienoly-[glycerolipid] + acceptor + H2O
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best substrate
i.e. calendic acid
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?
(9Z,12Z)-octadec-9,12-dienoyl-[glycerolipid] + reduced acceptor + O2
(9Z,11Z,13Z)-octadec-9,12,13-trienoyl-[glycerolipid] + acceptor + H2O
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(9Z,12Z,15Z)-octadec-9,12,15-trienoyl-[glycerolipid] + reduced acceptor + O2
(9Z,11E,13E,15Z)-octadec-9,11,13,15-tetraenoyl-[glycerolipid] + acceptor + H2O
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linoleoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + H2O
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(8E,10E,12Z)-octadeca-8,10,12-trienoate is calendic acid
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additional information
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FADX is a bifunctional enzyme with robust desaturase/conjugase activity
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(9Z,12Z)-octadec-9,12-dienoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadec-8,10,12-trienoly-[glycerolipid] + acceptor + H2O
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best substrate
i.e. calendic acid
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?
linoleoyl-[glycerolipid] + reduced acceptor + O2
(8E,10E,12Z)-octadeca-8,10,12-trienoyl-[glycerolipid] + acceptor + H2O
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(8E,10E,12Z)-octadeca-8,10,12-trienoate is calendic acid
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UniProt
brenda
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UniProt
brenda
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brenda
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additional information
not detected in seed
brenda
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brenda
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brenda
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brenda
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brenda
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physiological function
enzyme expression is occasionally associated with dramatic changes in morphology of the endoplasmic reticulum
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FAC2A_CALOF
374
4
43625
Swiss-Prot
other Location (Reliability: 2 )
FAC2B_CALOF
372
5
43365
Swiss-Prot
other Location (Reliability: 2 )
FADX_VERFO
386
5
44375
Swiss-Prot
other Location (Reliability: 5 )
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43600
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x * 43600, calculated from amino acid sequence
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x * 43600, calculated from amino acid sequence
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expressed in Nicotiana tabacum BY-2 cells and in Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae strain AMY-2alpha
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expressed in somatic soybean embryos and in Saccharomyces cerevisiae INVSc1 cells
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Dyer, J.M.; Chapital, D.C.; Kuan, J.C.; Mullen, R.T.; Turner, C.; McKeon, T.A.; Pepperman, A.B.
Molecular analysis of a bifunctional fatty acid conjugase/desaturase from tung. Implications for the evolution of plant fatty acid diversity
Plant Physiol.
130
2027-2038
2002
Vernicia fordii (Q8GZC2)
brenda
Cahoon, E.; Ripp, K.; Hall, S.; Kinney, A.
Formation of conjugated DELTA8,DELTA10-double bonds by DELTA12-oleic-acid desaturase-related enzymes. Biosynthetic origin of calendic acid
J. Biol. Chem.
276
2637-2643
2001
Calendula officinalis (Q9FPP7), Calendula officinalis (Q9FPP8)
brenda
Qiu, X.; Reed, D.; Hong, H.; MacKenzie, S.; Covello, P.
Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase
Plant Physiol.
125
847-855
2001
Calendula officinalis
brenda
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1.14.19.14 linoleoyl-lipid DELTA9 conjugase
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