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Information on EC 1.14.19.1 - stearoyl-CoA 9-desaturase and Organism(s) Mus musculus and UniProt Accession P13011

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EC Tree
IUBMB Comments
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
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This record set is specific for:
Mus musculus
UNIPROT: P13011
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
scd, stearoyl-coa desaturase, fatty acid desaturase, scd-1, stearoyl-coa desaturase 1, stearoyl-coa desaturase-1, stearoyl coa desaturase, stearoyl-coenzyme a desaturase, delta9-desaturase, delta9 desaturase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
stearoyl-CoA desaturase-2
-
acyl coenzyme A desaturase
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-
-
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acyl-CoA desaturase
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delta-9 desaturase
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DELTA9 desaturase
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DELTA9-acyl CoA desaturase
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DELTA9-desaturase
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-
-
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eicosatrienoyl-CoA desaturase
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-
-
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fatty acid 9-desaturase
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-
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fatty acid DELTA9-desaturase
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-
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fatty acid desaturase
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-
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fatty acyl CoA DELTA9-desaturase
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-
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fatty acyl DELTA9-desaturase
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fatty acyl-CoA desaturase
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long-chain fatty acid DELTA9-desaturase
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palmitoyl CoA desaturase
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palmitoyl-CoA desaturase
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SCD-1
SCD-2
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isoform
SCD-3
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isoform
SCD-4
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isoform
SCD2
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stearoyl coenzyme A desaturase
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-
-
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stearoyl-CoA (DELTA8) desaturase
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-
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stearoyl-CoA desaturase
stearoyl-CoA desaturase 1
stearoyl-CoA desaturase 2
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stearoyl-CoA desaturase-1
stearoyl-CoA desaturase-3
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stearoyl-CoA desaturase-4
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stearoyl-coenzyme A desaturase-1
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stearyl coenzyme A desaturase
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-
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stearyl-CoA desaturase
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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oxidation
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-
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reduction
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)
An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2).
CAS REGISTRY NUMBER
COMMENTARY hide
9014-34-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
palmitic acid + reduced acceptor + O2
palmitoleic acid + acceptor + H2O
show the reaction diagram
preferred substrate
-
-
?
stearate + reduced acceptor + O2
oleate + acceptor + H2O
show the reaction diagram
-
-
-
?
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
palmitoyl-CoA + AH2 + O2
palmitoleoyl-CoA + A + H2O
show the reaction diagram
-
-
-
?
palmitoyl-CoA + ferrocytochrome b5 + O2
palmitoleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + NADH + H+ + O2
palmitoleoyl-CoA + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
palmitoyl-CoA + NADH + O2
palmitoleoyl-CoA + NAD+ + H2O
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
show the reaction diagram
stearoyl-CoA + ferrocytochrome b5 + O2
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
stearoyl-CoA + NADH + H+ + O2
oleoyl-CoA + NAD+ + H2O
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + NADH + O2
oleoyl-CoA + NAD+ + H2O
show the reaction diagram
stearoyl-CoA + NADPH + H+ + O2
oleoyl-CoA + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
palmitoyl-CoA + AH2 + O2
palmitoleoyl-CoA + A + H2O
show the reaction diagram
-
-
-
?
stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
stearoyl-CoA + AH2 + O2
oleoyl-CoA + A + H2O
show the reaction diagram
-
-
-
?
stearoyl-CoA + ferrocytochrome b5 + O2 + H+
oleoyl-CoA + ferricytochrome b5 + H2O
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cytochrome b5
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ferrocytochrome b5
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NADPH
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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Zn2+
incorporation of zinc instead of iron into the protein is likely an artifact of protein overexpression, and zinc remains the predominant metal species even when the growth media and purification solutions are supplemented with iron. Coordination of both zinc ions is consistent with octahedral geometry with one missing ligand. The nine histidines are highly conserved, and eight of them belong to three histidine-containing motifs (two HXXHH motifs and one HX4H motif in SCD1) that are characteristic of integral membrane desaturases
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
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-
2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
2-(1-(1-(4-fluorophenyl)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
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2-(1-(2-(4-fluorophenoxy)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
2-(1-(3,5-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)thiazole-5-carboxamide
-
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((2-methylthiazol-5-yl)methyl)thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((3-methyl-1H-pyrazol-5-yl)methyl)-thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((5-methylpyrazin-2-yl)methyl)thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(piperidin-3-ylmethyl)thiazole-5-carboxamide trifluoroacetic acid salt
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
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2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(thiazol-2-ylmethyl)thiazole-5-carboxamide
-
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
-
2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
2-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)-1,3-thiazole-5-carboxamide
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MF-152
2-benzamido-4-methyl-N-phenylthiazole-5-carboxamide
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2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)benzyl]amino]quinoxalin-1(2H)-yl]ethyl]acetamide
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CVT-12,012
3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
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3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3,4-dimethyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazole-5-carboxamide
-
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(oxazol-4-ylmethyl)-1H-pyrazole-5-carboxamide
-
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
-
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
-
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-5-carboxamide
-
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-methyl-1H-pyrazole-5-carboxamide
-
3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2,3-dihydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxy-2-methylpropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-(5-[[3-(trifluoromethyl)phenyl]carbonyl]-1,3-thiazol-2-yl)benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
-
highly potent and orally bioavailable thiazole-based SCD-1 inhibitor
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-methoxy-N-{5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl}benzamide
-
-
3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-4-[(methylsulfonyl)amino]-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide
-
-
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
-
-
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazine
-
-
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazine
-
-
3-(3-hydroxypropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-(3-methyl-1,2,4-oxadiazol-5-yl)-6-[4-[2-(phenoxymethyl)phenoxy]piperidin-1-yl]pyridazine
-
-
3-(4-phenoxypiperidin-1-yl)-6-(5-propyl-1,2,4-oxadiazol-3-yl)pyridazine
-
-
3-(4-phenoxypiperidin-1-yl)-6-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pyridazine
-
-
3-(5-benzyl-1,2,4-oxadiazol-3-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
-
-
3-(5-benzyl-1,3,4-oxadiazol-2-yl)-6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazine
-
-
3-(5-methyl-1,2,4-oxadiazol-3-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
-
-
3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
3-[4-(2-benzylphenoxy)piperidin-1-yl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine
-
-
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(1H-imidazol-1-yl)pyridazine
-
-
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
-
-
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-4H-1,2,4-triazol-3-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(1H-pyrrol-1-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(1H-tetrazol-5-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(2-methyl-1H-imidazol-1-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-furan-3-ylpyridazine
-
-
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-pyridin-3-ylpyridazine
-
-
4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
-
-
4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
-
-
4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
-
-
4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
-
-
4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
4-methyl-2-(5-oxo-1-(4,4,4-trifluorobutyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
4-[2-(dimethylamino)ethoxy]-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
-
-
6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
-
6-[4-[(4-fluorophenyl)carbonyl]piperidin-1-yl]-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
-
-
cis-9,trans-11 conjugated linoleic acid
-
-
N-((1H-pyrazol-3-yl)methyl)-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
-
N-(2-hydroxy-2-phenylethyl)-6-(4-[[2-(trifluoromethoxy)phenyl]carbonyl]piperidin-1-yl)pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperidin-1-yl)pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-phenylethyl)-6-[4-(phenylcarbonyl)piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-phenylethyl)-6-[4-[(2-methoxyphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-phenylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-pyridin-2-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-pyridin-4-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-thiophen-2-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-hydroxy-2-thiophen-3-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-(2-phenylethyl)-4-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)benzamide
-
-
N-(2-phenylethyl)-5-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridine-2-carboxamide
-
-
N-(2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
-
-
N-(2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridine-3-carboxamide
-
-
N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
-
-
N-benzyl-2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxamide
-
N-[(2R)-2-hydroxy-2-phenylethyl]-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
-
-
N-[(2S)-2-hydroxy-2-phenylethyl]-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
-
-
N-[2-(2-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-[2-(3-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-[2-(4-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
-
-
N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide
-
-
N-[3-(3,4-dichlorobenzyl)-4-oxo-3,4-dihydroquinazolin-6-yl]-2-hydroxyacetamide
-
CVT-11,563
N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
-
-
N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
-
-
N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide
-
-
N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-(3-tert-butylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
-
-
N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
-
-
[2-methoxy-4-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
-
-
[2-methoxy-5-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
SCD2 mRNA expression is elevated 44fold in adipose tissue upon feeding mice a high fat diet, whereas SCD1 shows little response
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000002
(2E)-3-(4-methoxyphenyl)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]prop-2-enamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000055
2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.00003
2-(1-(1-(4-fluorophenyl)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000015
2-(1-(2-(4-fluorophenoxy)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000019
2-(1-(3,5-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000027
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000019
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000024
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((2-methylthiazol-5-yl)methyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000009
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((3-methyl-1H-pyrazol-5-yl)methyl)-thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000015
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((5-methylpyrazin-2-yl)methyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.001722
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000022
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000012
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.01
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(piperidin-3-ylmethyl)thiazole-5-carboxamide trifluoroacetic acid salt
Mus musculus
pH and temperature not specified in the publication
0.000022
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.00002
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000012
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(thiazol-2-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000065
2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000098
2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000022
3,4-bis(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000076
3,4-dimethoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.008218
3,4-dimethyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000147
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000165
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(oxazol-4-ylmethyl)-1H-pyrazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000023
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000007
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.002673
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000385
3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-methyl-1H-pyrazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.00217
3-(2,2-dihydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.009999
3-(2-hydroxy-2-methylpropoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000003
3-(2-hydroxyethoxy)-4-(2-methoxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.001
3-(2-hydroxyethoxy)-4-methoxy-N-(5-[[3-(trifluoromethyl)phenyl]carbonyl]-1,3-thiazol-2-yl)benzamide
Mus musculus
-
IC50 above 0.001 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000836
3-(2-hydroxyethoxy)-4-methoxy-N-methyl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000002
3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
Mus musculus
-
in 250 mM sucrose, 150 mM KCl, 40 mM NaF, 5 mM MgCl2, 100 mM sodium phosphate, pH 7.4, at 37°C
0.000003
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethoxy)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.00001
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3,4-thiadiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000002
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000076
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)benzyl]thiophen-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.001
3-(2-hydroxyethoxy)-4-methoxy-N-[5-[3-(trifluoromethyl)phenoxy]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
IC50 above 0.001 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000006
3-(2-hydroxyethoxy)-4-morpholin-4-yl-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.009999
3-(2-hydroxyethoxy)-4-[(methylsulfonyl)amino]-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000276
3-(2-hydroxyethoxy)-N-(5-[hydroxy[3-(trifluoromethyl)phenyl]methyl]-1,3-thiazol-2-yl)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.00001
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
Mus musculus
-
pH 7.5
0.000026
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazine
Mus musculus
-
pH 7.5
0.0000074
3-(3-benzyl-1,2,4-oxadiazol-5-yl)-6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazine
Mus musculus
-
pH 7.5
0.000085
3-(3-methyl-1,2,4-oxadiazol-5-yl)-6-[4-[2-(phenoxymethyl)phenoxy]piperidin-1-yl]pyridazine
Mus musculus
-
pH 7.5
0.00133
3-(4-phenoxypiperidin-1-yl)-6-(5-propyl-1,2,4-oxadiazol-3-yl)pyridazine
Mus musculus
-
pH 7.5
0.00082
3-(4-phenoxypiperidin-1-yl)-6-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]pyridazine
Mus musculus
-
pH 7.5
0.00004
3-(5-benzyl-1,2,4-oxadiazol-3-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
Mus musculus
-
pH 7.5
0.000012
3-(5-benzyl-1,3,4-oxadiazol-2-yl)-6-[4-(2-chlorophenoxy)piperidin-1-yl]pyridazine
Mus musculus
-
pH 7.5
0.00022
3-(5-methyl-1,2,4-oxadiazol-3-yl)-6-(4-phenoxypiperidin-1-yl)pyridazine
Mus musculus
-
pH 7.5
0.000528
3-methoxy-4-(2-morpholin-4-ylethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000193
3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000053
3-[4-(2-benzylphenoxy)piperidin-1-yl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine
Mus musculus
-
pH 7.5
0.000004
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(1H-imidazol-1-yl)pyridazine
Mus musculus
-
below, pH 7.5
0.0000045
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridazine
Mus musculus
-
pH 7.5
0.000004
3-[4-(2-chloro-5-fluorophenoxy)piperidin-1-yl]-6-(5-methyl-4H-1,2,4-triazol-3-yl)pyridazine
Mus musculus
-
pH 7.5
0.00001
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(1H-pyrrol-1-yl)pyridazine
Mus musculus
-
pH 7.5
0.00037
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(1H-tetrazol-5-yl)pyridazine
Mus musculus
-
pH 7.5
0.00002
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(2-methyl-1H-imidazol-1-yl)pyridazine
Mus musculus
-
pH 7.5
0.000032
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine
Mus musculus
-
pH 7.5
0.00002
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine
Mus musculus
-
pH 7.5
0.00001
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-(5-methyl-1,2,4-oxadiazol-3-yl)pyridazine
Mus musculus
-
pH 7.5
0.000092
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-furan-3-ylpyridazine
Mus musculus
-
pH 7.5
0.000004
3-[4-(2-chlorophenoxy)piperidin-1-yl]-6-pyridin-3-ylpyridazine
Mus musculus
-
below, pH 7.5
0.000004
4-(2-bromophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
below
0.000006
4-(2-chloro-4-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000004
4-(2-chloro-5-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
below
0.00033
4-(2-chloro-6-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.00059
4-(2-chlorophenoxy)-N-phenylpiperidine-1-carboxamide
Mus musculus
-
-
0.00001
4-(2-chlorophenoxy)-N-[3-(1H-imidazol-2-yl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000008
4-(2-chlorophenoxy)-N-[3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000008
4-(2-chlorophenoxy)-N-[3-(ethylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000004
4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
below
0.00081
4-(2-chlorophenoxy)-N-[3-[(1-methylethyl)carbamoyl]phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000098
4-(2-fluorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000003
4-(2-hydroxyethoxy)-3-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000081
4-(2-methoxyphenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.00002
4-(3-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Mus musculus
-
-
0.000008
4-(acetylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000004
4-(diethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000007
4-(dimethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000004
4-(ethylamino)-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000002
4-ethoxy-3-(2-hydroxyethoxy)-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]benzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000004
4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
Mus musculus
-
in 250 mM sucrose, 150 mM KCl, 40 mM NaF, 5 mM MgCl2, 100 mM sodium phosphate, pH 7.4, at 37°C
0.000007
4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000021
4-methyl-2-(5-oxo-1-(4,4,4-trifluorobutyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000014
4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000016
4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000005
6-methoxy-N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000074
6-[4-[(4-fluorophenyl)carbonyl]piperidin-1-yl]-N-(2-hydroxy-2-phenylethyl)pyridazine-3-carboxamide
Mus musculus
-
-
0.000046
N-((1H-pyrazol-3-yl)methyl)-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
Mus musculus
pH and temperature not specified in the publication
0.000005
N-(2-hydroxy-2-phenylethyl)-6-(4-[[2-(trifluoromethoxy)phenyl]carbonyl]piperidin-1-yl)pyridazine-3-carboxamide
Mus musculus
-
-
0.000002
N-(2-hydroxy-2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperidin-1-yl)pyridazine-3-carboxamide
Mus musculus
-
-
0.000153
N-(2-hydroxy-2-phenylethyl)-6-[4-(phenylcarbonyl)piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000052
N-(2-hydroxy-2-phenylethyl)-6-[4-[(2-methoxyphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000007
N-(2-hydroxy-2-phenylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000095
N-(2-hydroxy-2-pyridin-2-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000037
N-(2-hydroxy-2-pyridin-3-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000034
N-(2-hydroxy-2-pyridin-4-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000007
N-(2-hydroxy-2-thiophen-2-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000003
N-(2-hydroxy-2-thiophen-3-ylethyl)-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.00015
N-(2-phenylethyl)-4-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)benzamide
Mus musculus
-
-
0.00037
N-(2-phenylethyl)-5-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridine-2-carboxamide
Mus musculus
-
-
0.000006
N-(2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
Mus musculus
-
-
0.000194
N-(2-phenylethyl)-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridine-3-carboxamide
Mus musculus
-
-
0.00001
N-(3-carbamoylphenyl)-4-(2-chlorophenoxy)piperidine-1-carboxamide
Mus musculus
-
-
0.000025
N-[(2R)-2-hydroxy-2-phenylethyl]-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
Mus musculus
-
-
0.000066
N-[(2S)-2-hydroxy-2-phenylethyl]-6-(4-[[2-(trifluoromethyl)phenyl]carbonyl]piperazin-1-yl)pyridazine-3-carboxamide
Mus musculus
-
-
0.000009
N-[2-(2-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000005
N-[2-(3-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000007
N-[2-(4-fluorophenyl)-2-hydroxyethyl]-6-[4-[(2-methylphenyl)carbonyl]piperidin-1-yl]pyridazine-3-carboxamide
Mus musculus
-
-
0.000044
N-[2-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-5-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000049
N-[3-(2-hydroxyethoxy)-4-methoxyphenyl]-5-[3-(trifluoromethyl)benzyl]-1,3-thiazole-2-carboxamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000017
N-[3-(methylcarbamoyl)phenyl]-4-(2-methylphenoxy)piperidine-1-carboxamide
Mus musculus
-
-
0.00037
N-[3-(methylcarbamoyl)phenyl]-4-phenoxypiperidine-1-carboxamide
Mus musculus
-
-
0.01
N-[3-(tert-butylcarbamoyl)phenyl]-4-(2-chlorophenoxy)piperidine-1-carboxamide
Mus musculus
-
above
0.000009
N-[5-(2,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000008
N-[5-(3,4-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000002
N-[5-(3,4-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000007
N-[5-(3,5-dichlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000001
N-[5-(3,5-difluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000001
N-[5-(3-chloro-4-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000001
N-[5-(3-chlorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000022
N-[5-(3-fluoro-4-methylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.000002
N-[5-(3-fluorobenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.001307
N-[5-(3-tert-butylbenzyl)-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000006
N-[5-[3,5-bis(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.01
N-[5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]naphthalene-2-carboxamide
Mus musculus
-
IC50 above 0.01 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C
0.0000002
N-[5-[4-fluoro-3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]-3-(2-hydroxyethoxy)-4-methoxybenzamide
Mus musculus
-
in 100 mM sodium phosphate, pH 7.4, at 37°C
0.009999
[2-methoxy-5-([5-[3-(trifluoromethyl)benzyl]-1,3-thiazol-2-yl]carbamoyl)phenoxy]acetic acid
Mus musculus
-
IC50 above 0.009999 mM, in 100 mM sodium phosphate, pH 7.4, at 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0002
-
129S6/SvEvTac mice under low-fat diet, liver microsomes, stearoyl-CoA as substrate
0.0004
-
129S6/SvEvTac mice under high-fat diet, liver microsomes, stearoyl-CoA as substrate
0.0011
-
C57Bl/B6 mice under low-fat diet, liver microsomes, stearoyl-CoA as substrate
0.0016
-
C57Bl/B6 mice under high-fat diet, liver microsomes, stearoyl-CoA as substrate
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
-
assay at
7.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
23
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
SCD2 is highly localized
Manually annotated by BRENDA team
exclusively expressed in heart, no repression by dietary polyunsaturated fatty acids, induction in SCD1-deficient animals
Manually annotated by BRENDA team
SCD2 isoform only in early stages
Manually annotated by BRENDA team
-
contains high amounts
Manually annotated by BRENDA team
-
ball
Manually annotated by BRENDA team
-
isoform SCD-2
Manually annotated by BRENDA team
-
isoforms SCD-1 and SCD-2
Manually annotated by BRENDA team
-
isoform SCD-1
Manually annotated by BRENDA team
-
training induces SCD1 mRNA level
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
an integral protein anchored in the endoplasmic reticulum membrane
Manually annotated by BRENDA team
additional information
SCD-1 consists of a cytosolic domain containing a di-metal active center and four alpha-helices forming a tight hydrophobic core, which is situated in the endoplasmic reticulum membrane
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
isozymes SCD1 and SCD3 share 89% primary sequence identity, but they yield remarkably different total fatty acid profiles in the recombinant yeast host cells, likely reflecting differences in their preferences for reaction with 16:0 and 18:0 substrates
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SCD2_MOUSE
358
4
40916
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37000
-
SDS-PAGE
41000
-
Myc or HA epitope tagged proteins expressed in HeLa cells, immunoblot using anti-Myc and ant-HA antibodies
additional information
-
SCD protein undetectable in 24 microg/day leptin-treated ob/ob mice with or without exogenous insulin treatment
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 41000., SDS-PAGE
additional information
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified DELTA2–23 N-terminally truncated recombinant isozyme SCD1 bound to stearoyl-CoA and two ions of Zn2+ instead of Fe2+, X-ray diffraction structure determination and analysis at 2.6 A resolution, single-wavelength anomalous dispersion
purified free enzyme, X-ray diffraction structure determination and analysis at 2.6 A resolution. The two iron cations are replaced by zinc cations in the crystal structure
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C222S
-
with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C233S
-
with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C322S
-
with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C92S
-
with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
C92S/C97S/C222S/C322S
-
with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity 5fold increased compared with cells transfected with the empty vector, clear ER pattern
C97S
-
with Myc epitope tagged to the C terminus, expressed in HeLa cells, actitivity comparable to that of the wild-type
I112A/E113L
site-directed mutagenesis, the mutation is able to convert isozyme SCD3 from exclusively a 16:0 desaturase into a predominantly 18:0 desaturase
V119A/D281Q/P282S E113L
site-directed mutagenesis, the mutation of the residues which are located away from the end of the substrate tunnel, causes no change in the reaction specificity of isozyme SCD3
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant isozyme SCD1 from Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, incorporation of zinc instead of iron into the protein is likely an artifact of protein overexpression, and zinc remains the predominant metal species even when the growth media and purification solutions are supplemented with iron
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in HeLa cells, tagged with myc epitope at the C terminus or HA epitope
-
four stearoyl-CoA desaturase genes
-
gene scd1, real-time PCR expression analysis
gene scd1, recombinant expression of isozyme SCD1 in Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, which allows growth in media lacking unsaturated fatty acids. Optimization of enzyme expression method
gene scd3, recombinant expression of wild-type and mutant isozymes SCD3 in Saccharomyces cerevisiae monounsaturated fatty acid auxotroph L8-14C, wild-type exxpression allows growth in media lacking unsaturated fatty acids
overexpression in CHO cells results in a significant increase in the rate of triglyceride synthesis
SCD1 and SCD2 expression analysis
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
dietary saturated fat strongly induces Scd1 expression
-
hepatic SCD1 expression increases in experimental steatosis resulting from high fat diet and decreases in a methionine-choline-deficient dietary model of steatohepatitis resulting in the latter situation in significantly increased hepatic saturated fatty acid levels
-
higher levels of stearoyl lysophosphatidylcholine and lower levels of oleoyl lysophosphatidylcholine in dextran sulfate sodium-treated mice compared to controls lead to the identification of dextran sulfate sodium-elicited inhibition of SCD1 expression in liver, Citrobacter rodentium-induced colitis and lipopolysaccharide treatment also suppresses SCD1 expression in liver
-
intracerebroventricular glucose administration strongly decreases hepatic Scd1
-
isoform SCD-1 expression is dramatically induced in liver and heart in response to high-carbohydrate diet, SCD-1 expression is also induced by nuclear sterol regulatory element-binding protein-1 via the sterol regulatory element in its promoter, in aortic endothelial cells liver X receptor beta activation increases SCD-1 mRNA and protein expression
-
the enzyme level is dramatically increased in high-fat diet-fed myeloid differentiation factor 88-deficient mice liver
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
SCD-1 is a promising target for the treatment of cancer, skin disorders and metabolic diseases, development of clinical drug candidates
medicine
pharmacology
enhancing SCD1-mediated desaturation of saturated fatty acids and subsequent formation of neutral lipid droplets may become a promising therapeutic target to reduce saturated fatty acid-induced lipotoxicity in the pathogenesis of diabetic nephropathy
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Miyazaki, M.; Kim, H.J.; Man, W.C.; Ntambi, J.M.
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2,3-diacylglycerol
J. Biol. Chem.
276
39455-39461
2001
Mus musculus
Manually annotated by BRENDA team
Miyazaki, M.; Jacobson, M.J.; Man, W.C.; Cohen, P.; Asilmaz, E.; Friedman, J.M.; Ntambi, J.M.
Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors
J. Biol. Chem.
278
33904-33911
2003
Mus musculus (P13011), Mus musculus
Manually annotated by BRENDA team
Jiang, G.; Li, Z.; Liu, F.; Ellsworth, K.; Dallas-Yang, Q.; Wu, M.; Ronan, J.; Esau, C.; Murphy, C.; Szalkowski, D.; Bergeron, R.; Doebber, T.; Zhang, B.B.
Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1
J. Clin. Invest.
115
1030-1038
2005
Mus musculus
Manually annotated by BRENDA team
Biddinger, S.B.; Almind, K.; Miyazaki, M.; Kokkotou, E.; Ntambi, J.M.; Kahn, C.R.
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome
Diabetes
54
1314-1323
2005
Mus musculus
Manually annotated by BRENDA team
Biddinger, S.B.; Miyazaki, M.; Boucher, J.; Ntambi, J.M.; Kahn, C.R.
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c
Diabetes
55
2032-2041
2006
Mus musculus
Manually annotated by BRENDA team
Dobrzyn, P.; Dobrzyn, A.
Stearoyl-CoA desaturase: a new therapeutic target of liver steatosis
Drug Develop. Res.
67
643-650
2006
Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q6T707), Mus musculus (Q99PL7)
-
Manually annotated by BRENDA team
Mutch, D.M.; Grigorov, M.; Berger, A.; Fay, L.B.; Roberts, M.A.; Watkins, S.M.; Williamson, G.; German, J.B.
An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet
FASEB J.
19
599-601
2005
Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q99PL7), Mus musculus, Mus musculus Rj:NMRI (P13011), Mus musculus Rj:NMRI (P13516), Mus musculus Rj:NMRI (Q99PL7)
Manually annotated by BRENDA team
Man, W.C.; Miyazaki, M.; Chu, K.; Ntambi, J.M.
Membrane topology of mouse stearoyl-CoA desaturase 1
J. Biol. Chem.
281
1251-1260
2006
Mus musculus
Manually annotated by BRENDA team
Sampath, H.; Miyazaki, M.; Dobrzyn, A.; Ntambi, J.M.
Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat
J. Biol. Chem.
282
2483-2493
2007
Mus musculus
Manually annotated by BRENDA team
Flowers, M.T.; Miyazaki, M.; Liu, X.; Ntambi, J.M.
Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
J. Clin. Invest.
116
1478-1481
2006
Mus musculus
Manually annotated by BRENDA team
Gutierrez-Juarez, R.; Pocai, A.; Mulas, C.; Ono, H.; Bhanot, S.; Monia, B.P.; Rossetti, L.
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance
J. Clin. Invest.
116
1686-1695
2006
Mus musculus, Rattus norvegicus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Dobrzyn, A.; Dobrzyn, P.
Stearoyl-CoA desaturase - a new player in skeletal muscle metabolism regulation
J. Physiol. Pharmacol.
57 Suppl 10
31-42
2006
Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Dobrzyn, A.; Ntambi, J.M.
Stearoyl-CoA desaturase as a new drug target for obesity treatment
Obes. Rev.
6
169-174
2005
Mus musculus
Manually annotated by BRENDA team
Dobrzyn, P.; Sampath, H.; Dobrzyn, A.; Miyazaki, M.; Ntambi, J.M.
Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart
Am. J. Physiol. Endocrinol. Metab.
294
E357-E364
2008
Mus musculus
Manually annotated by BRENDA team
Xin, Z.; Zhao, H.; Serby, M.D.; Liu, B.; Liu, M.; Szczepankiewicz, B.G.; Nelson, L.T.; Smith, H.T.; Suhar, T.S.; Janis, R.S.; Cao, N.; Camp, H.S.; Collins, C.A.; Sham, H.L.; Surowy, T.K.; Liu, G.
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
Bioorg. Med. Chem. Lett.
18
4298-4302
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Christianson, J.L.; Nicoloro, S.; Straubhaar, J.; Czech, M.P.
Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells
J. Biol. Chem.
283
2906-2916
2008
Mus musculus
Manually annotated by BRENDA team
Liu, G.; Lynch, J.K.; Freeman, J.; Liu, B.; Xin, Z.; Zhao, H.; Serby, M.D.; Kym, P.R.; Suhar, T.S.; Smith, H.T.; Cao, N.; Yang, R.; Janis, R.S.; Krauser, J.A.; Cepa, S.P.; Beno, D.W.; Sham, H.L.; Collins, C.A.; Surowy, T.K.; Camp, H.S.
Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors
J. Med. Chem.
50
3086-3100
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Paton, C.M.; Ntambi, J.M.
Biochemical and physiological function of stearoyl-CoA desaturase
Am. J. Physiol. Endocrinol. Metab.
297
E28-E37
2009
Mus musculus
Manually annotated by BRENDA team
Macdonald, M.L.; Bissada, N.; Vallance, B.A.; Hayden, M.R.
Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis
Biochim. Biophys. Acta
1791
1166-1172
2009
Mus musculus
Manually annotated by BRENDA team
Flowers, M.T.; Ntambi, J.M.
Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
Biochim. Biophys. Acta
1791
85-91
2009
Mus musculus
Manually annotated by BRENDA team
Uto, Y.; Ogata, T.; Harada, J.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Abe, M.; Kurikawa, N.; Kawamura, S.; Yamato, M.; Osumi, J.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide
Bioorg. Med. Chem. Lett.
19
4151-4158
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Uto, Y.; Ogata, T.; Kiyotsuka, Y.; Miyazawa, Y.; Ueno, Y.; Kurata, H.; Deguchi, T.; Yamada, M.; Watanabe, N.; Takagi, T.; Wakimoto, S.; Okuyama, R.; Konishi, M.; Kurikawa, N.; Kono, K.; Osumi, J.
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation
Bioorg. Med. Chem. Lett.
19
4159-4166
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Uto, Y.; Ogata, T.; Kiyotsuka, Y.; Ueno, Y.; Miyazawa, Y.; Kurata, H.; Deguchi, T.; Watanabe, N.; Konishi, M.; Okuyama, R.; Kurikawa, N.; Takagi, T.; Wakimoto, S.; Ohsumi, J.
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats
Bioorg. Med. Chem. Lett.
20
341-345
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chen, C.; Shah, Y.M.; Morimura, K.; Krausz, K.W.; Miyazaki, M.; Richardson, T.A.; Morgan, E.T.; Ntambi, J.M.; Idle, J.R.; Gonzalez, F.J.
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis
Cell Metab.
7
135-147
2008
Mus musculus
Manually annotated by BRENDA team
Sampath, H.; Flowers, M.T.; Liu, X.; Paton, C.M.; Sullivan, R.; Chu, K.; Zhao, M.; Ntambi, J.M.
Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
J. Biol. Chem.
284
19961-19973
2009
Mus musculus
Manually annotated by BRENDA team
Li, Z.Z.; Berk, M.; McIntyre, T.M.; Feldstein, A.E.
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase
J. Biol. Chem.
284
5637-5644
2009
Mus musculus
Manually annotated by BRENDA team
Stamatikos, A.D.; Paton, C.M.
Role of stearoyl-CoA desaturase-1 in skeletal muscle function and metabolism
Am. J. Physiol. Endocrinol. Metab.
305
E767-E775
2013
Mus musculus
Manually annotated by BRENDA team
Yokoyama, S.; Hosoi, T.; Ozawa, K.
Stearoyl-CoA desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice
Gene
497
340-343
2012
Mus musculus
Manually annotated by BRENDA team
Sampath, H.; Ntambi, J.M.
The role of Stearoyl-CoA desaturase-1 in skin integrity and whole body energy balance
J. Biol. Chem.
289
2482-2488
2014
Mus musculus
Manually annotated by BRENDA team
Koeberle, A.; Loeser, K.; Thuermer, M.
Stearoyl-CoA desaturase-1 and adaptive stress signaling
Biochim. Biophys. Acta
1861
1719-1726
2016
Homo sapiens (O00767), Mus musculus (P13516)
Manually annotated by BRENDA team
Sun, S.; Zhang, Z.; Pokrovskaia, N.; Chowdhury, S.; Jia, Q.; Chang, E.; Khakh, K.; Kwan, R.; McLaren, D.G.; Radomski, C.C.; Ratkay, L.G.; Fu, J.; Dales, N.A.; Winther, M.D.
Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
Bioorg. Med. Chem.
23
455-465
2015
Homo sapiens (O00767), Mus musculus (P13516)
Manually annotated by BRENDA team
Iwai, T.; Kume, S.; Chin-Kanasaki, M.; Kuwagata, S.; Araki, H.; Takeda, N.; Sugaya, T.; Uzu, T.; Maegawa, H.; Araki, S.I.
Stearoyl-CoA desaturase-1 protects cells against lipotoxicity-mediated apoptosis in proximal tubular cells
Int. J. Mol. Sci.
17
E1868
2016
Mus musculus (P13516)
Manually annotated by BRENDA team
Bai, Y.; McCoy, J.G.; Levin, E.J.; Sobrado, P.; Rajashankar, K.R.; Fox, B.G.; Zhou, M.
X-ray structure of a mammalian stearoyl-CoA desaturase
Nature
524
252-256
2015
Mus musculus (P13516), Mus musculus (Q99PL7), Mus musculus
Manually annotated by BRENDA team
Rodriguez-Cuenca, S.; Whyte, L.; Hagen, R.; Vidal-Puig, A.; Fuller, M.
Stearoyl-CoA desaturase 1 Is a key determinant of membrane lipid composition in 3T3-L1 adipocytes
PLoS ONE
11
e0162047
2016
Mus musculus (P13516)
Manually annotated by BRENDA team
ALJohani, A.M.; Syed, D.N.; Ntambi, J.M.
Insights into stearoyl-CoA desaturase-1 regulation of systemic metabolism
Trends Endocrinol. Metab.
28
831-842
2017
Homo sapiens (O00767), Homo sapiens (Q86SK9), Mus musculus (P13011), Mus musculus (P13516), Mus musculus (Q8BNZ5), Mus musculus (Q8CFY4)
Manually annotated by BRENDA team