Information on EC 1.14.18.B1 - 5,6-dihydroxyindole-2-carboxylic acid oxidase

for references in articles please use BRENDA:EC1.14.18.B1
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.18.B1
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
5,6-dihydroxyindole-2-carboxylic acid oxidase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,6-dihydroxyindole-2-carboxylic acid + O2 = indole-5,6-quinone-2-carboxylic acid + H2O
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
5,6-dihydroxyindole-2-carboxylic acid:oxygen oxidoreductase
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2
histone H3 N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
histone H3 N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2
histone H3 N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
Q9UPP1
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additional information
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Q9UPP1
enzyme PHF8 binds and stabilizes histone H3 N6,N6,N6-trimethyl-L-lysine4, PHF8 is important in maintaining H3K4me3 levels. PHF8 cooperates with KDM3A
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
GSK-J4
a small molecule inhibitor, specifically inhibits the H3K27 demethylase. GSK-J4 also decreases phosphorylation of ERK1/2 (p-ERK1/2) in zebrafish larvae
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in the zebrafish lateral line neuromasts
Manually annotated by BRENDA team
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epidermal keratinocytes
Manually annotated by BRENDA team
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CD4+ cells, expression analysis of enzyme in cells from healthy persons and systemic lupus erythematosus patients: significantly decreased H3K27me3 levels and increased JMJD3 binding are detected within the ITGAL (CD11a) promoter locus in SLE CD4+ T cells compared with those in healthy CD4+ T cells
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene KDM6B or JMJD3, quantitative PCR enzyme expression analysis
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overexpression of JMJD3 through the transfection of pcDNA3.1-JMJD3 into healthy donor CD4+ T cells leading to an increase in JMJD3 enrichment, a decrease in H3K27me3 enrichment within the ITGAL (CD11a) promoter, and upregulation of CD11a expression, resulting in T and B cell hyperactivity
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
upregulation of histone H3K27 demethylase JMJD3 by long noncoding RNA HOTAIR, i.e. homeobox transcript antisense intergenic RNA, a kind of non-protein coding transcripts longer than 200 nucleotides. HOTAIR is an important promoter in metastasis of renal cell carcinoma and also plays a dual regulatory role in chromatin state by effecting both histone metylation and demethylation at different gene loci. HOTAIR can affect histone H3K27 methylation and its target genes' expression
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upregulation of JMJD3 expression in scratch-wounded keratinocytes
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine