Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 1.14.18.6 - 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Eckhardt, M.; Yaghootfam, A.; Fewou, S.; Zller, I.; Gieselmann, V.
A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin
Biochem. J.
388
245-254
2005
Mus musculus (Q5MPP0), Mus musculus
Manually annotated by BRENDA team
Meixner, M.; Jungnickel, J.; Grothe, C.; Gieselmann, V.; Eckhardt, M.
Myelination in the absence of UDP-galactose: Ceramide galactosyl-transferase and fatty acid 2-hydroxylase
BMC Neurosci.
12
22
2011
Mus musculus (Q5MPP0)
Manually annotated by BRENDA team
Herrero, A.B.; Astudillo, A.M.; Balboa, M.A.; Cuevas, C.; Balsinde, J.; Moreno, S.
Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734
Cancer Res.
68
9779-9787
2008
Saccharomyces cerevisiae (Q03529), Saccharomyces cerevisiae, Homo sapiens (Q7L5A8), Homo sapiens
Manually annotated by BRENDA team
Hama, H.; Young, D.A.; Radding, J.A.; Ma, D.; Tang, J.; Stock, S.D.; Takemoto, J.Y.
Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E
FEBS Lett.
478
26-28
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Mitchell, A.; Martin, C.
Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids
J. Biol. Chem.
272
28281-28288
1997
Saccharomyces cerevisiae (Q03529)
Manually annotated by BRENDA team
Alderson, N.; Rembiesa, B.; Walla, M.; Bielawska, A.; Bielawski, J.; Hama, H.
The human FA2H gene encodes a fatty acid 2-hydroxylase
J. Biol. Chem.
279
48562-48568
2004
Homo sapiens (Q7L5A8), Homo sapiens
Manually annotated by BRENDA team
Uchida, Y.; Hama, H.; Alderson, N.L.; Douangpanya, S.; Wang, Y.; Crumrine, D.A.; Elias, P.M.; Holleran, W.M.
Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation
J. Biol. Chem.
282
13211-13219
2007
Homo sapiens (Q7L5A8), Homo sapiens
Manually annotated by BRENDA team
Alderson, N.L.; Hama, H.
Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T Schwannoma cells
J. Lipid Res.
50
1203-1208
2009
Rattus norvegicus
Manually annotated by BRENDA team
Guo, L.; Zhang, X.; Zhou, D.; Okunade, A.; Su, X.
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers
J. Lipid Res.
53
1327-1335
2012
Mus musculus (Q5MPP0), Homo sapiens (Q7L5A8), Homo sapiens
Manually annotated by BRENDA team
Dan, P.; Edvardson, S.; Bielawski, J.; Hama, H.; Saada, A.
2-hydroxylated sphingomyelin profiles in cells from patients with mutated fatty acid 2-hydroxylase
Lipids Health Dis.
10
84
2011
Homo sapiens
Manually annotated by BRENDA team
Tani, M.; Kuge, O.
Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids
Mol. Microbiol.
78
395-413
2010
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Dunn, T.M.; Haak, D.; Monaghan, E.; Beeler, T.J.
Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain
Yeast
14
311-321
1998
Saccharomyces cerevisiae (Q03529), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Li, R.; Xin, S.; Tao, C.; Jin, X.; Li, H.
Cotton ascorbate oxidase promotes cell growth in cultured tobacco bright Yellow-2 cells through generation of apoplast oxidation
Int. J. Mol. Sci.
18
1346
2017
Mus musculus
Manually annotated by BRENDA team
Zhu, G.; Koszelak-Rosenblum, M.; Connelly, S.M.; Dumont, M.E.; Malkowski, M.G.
The crystal structure of an integral membrane fatty acid alpha-hydroxylase
J. Biol. Chem.
290
29820-29833
2015
Saccharomyces cerevisiae (Q03529), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Takeda, S.; Ikeda, E.; Su, S.; Harada, M.; Okazaki, H.; Yoshioka, Y.; Nishimura, H.; Ishii, H.; Kakizoe, K.; Taniguchi, A.; Tokuyasu, M.; Himeno, T.; Watanabe, K.; Omiecinski, C.J.; Aramaki, H.
DELTA9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression possible involvement of induced levels of PPARalpha in MDA-MB-231 breast cancer cells
Toxicology
326
18-24
2014
Homo sapiens
Manually annotated by BRENDA team
Herzfeld, E.; Speh, L.; Strauss, C.; Scheller, C.
Nimodipine but not nifedipine promotes expression of fatty acid 2-hydroxylase in a surgical stress model based on neuro2a cells
Int. J. Mol. Sci.
18
E964
2017
Mus musculus (Q5MPP0)
Manually annotated by BRENDA team
Nagano, M.; Ishikawa, T.; Ogawa, Y.; Iwabuchi, M.; Nakasone, A.; Shimamoto, K.; Uchimiya, H.; Kawai-Yamada, M.
Arabidopsis Bax inhibitor-1 promotes sphingolipid synthesis during cold stress by interacting with ceramide-modifying enzymes
Planta
240
77-89
2014
Saccharomyces cerevisiae
Manually annotated by BRENDA team