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Information on EC 1.14.18.4 - phosphatidylcholine 12-monooxygenase

for references in articles please use BRENDA:EC1.14.18.4

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IUBMB Comments

The enzyme, characterized from the plant Ricinus communis (castor bean), is involved in production of the 12-hydroxylated fatty acid ricinoleate. The enzyme, which shares sequence similarity with fatty-acyl desaturases, requires a cytochrome b5 as the electron donor.

The enzyme appears in viruses and cellular organisms

Synonyms
fah12, oleoyl-12-hydroxylase, cpfah, cpfah12, oleate 12-hydroxylase, oleate hydroxylase, lfah12, oleate delta12-hydroxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + 2 ferrocytochrome b5 + O2 + 2 H+ = a 1-acyl-2-[(12R)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + 2 ferricytochrome b5 + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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